Late Miocene magnetostratigraphy of Jianzha Basin in the northeastern margin of the Tibetan Plateau and changes in the East Asian summer monsoon

Jianzha Basin is located in the northeastern Tibetan Plateau (NETP) and contains a thick sequence of Cenozoic sediments that are an archive of information about the growth of the Tibetan Plateau and the evolution of the arid environment of the interior of Asia. Here, we present magnetostratigraphic and palaeoenvironmental records from a 361-m-thick sequence of Late Cenozoic eolian Red Clay and intercalated fluviolacustrine deposits in the Jianzha Basin. The magnetostratigraphic results show that the sediments have recorded a continuous geomagnetic polarity sequence from C5r.3r to C3r, spanning the interval from 11.8 to 5.8Ma in the Late Miocene. There are two intervals of rapidly fluctuating sedimentation rates between similar to 10 and similar to 6Ma, which we interpret as a response to a series of uplifts and expansions to the north and to the east in the NETP. The fluctuations in Rb/Sr ratio and magnetic susceptibility before similar to 8.57Ma reflect intensified East Asian summer monsoon (EASM) precipitation which resulted from the growth of the NETP. From similar to 8.57 to similar to 7.21Ma, the EASM was impacted by global cooling and ice build-up in the Northern Hemisphere in addition to the uplift of the Tibetan Plateau (TP) in the Late Miocene. From similar to 8.57 to similar to 7.21Ma, there is a lack of coherency between the fluctuations in MS and Rb/Sr ratio; however, subsequently, there is significant coherency between the Rb/Sr ratio and the deep-sea oxygen isotope record present. This suggests that from similar to 8.57Ma, the eolian Red Clay sediments in the Jianzha Basin were significantly affected by the addition of dust derived from the deforming and uplifting areas of the TP

Whole lung lavage combined with Granulocyte-macrophage colony stimulating factor inhalation for an adult case of refractory pulmonary alveolar proteinosis

BACKGROUND: Whole-lung lavage (WLL) is classically the first-line treatment for symptomatic pulmonary alveolar proteinosis (PAP). However, some patients require multiple WLLs because of refractory nature of their PAP. In this instance, these patients may benefit from new treatment regimens, and new therapies should be tried for these patients. CASE PRESENTATION: We describe a 47-year-old Chinese woman who was confidently diagnosed with pulmonary alveolar proteinosis (PAP) after bronchoalveolar lavage and transbronchial lung biopsy. The patient received four sessions of bilateral whole lung lavage (WLL) and one session of WLL in combination with plasmapheresis, each only producing short-term symptomatic relief. The patient was given a trial of combination therapy, which consisted of WLL and Granulocyte-macrophage colony-stimulating factor (GM-CSF) inhalation. The patient showed a gradual improvement in oxygenation and her daily activity, as well as a dramatic improvement in her pulmonary CT examination. CONCLUSION: Bilateral WLL, in combination with GM-CSF inhalation, may be an effective treatment option for severe refractory PAP

ISLR interacts with MGAT5 to promote the malignant progression of human gastric cancer AGS cells

Objective(s): Gastric cancer is a common malignant tumor with high morbidity and mortality. The present study aimed to investigate the role of the immunoglobulin superfamily containing leucine-rich repeat (ISLR) gene in gastric cancer and examine whether ISLR could interact with N-acetylglucosaminyltransferase V (MGAT5) to affect the malignant progression of gastric cancer. Materials and Methods: The expression of ISLR and MGAT5 in human normal gastric epithelial cells and human gastric cancer cells, and the transfection efficiency of ISLR interference plasmids and MGAT5 overexpression plasmids were all detected by reverse transcription-quantitative PCR (RT-qPCR) and western blot. The viability, proliferation, migration and invasion, and epithelial-mesenchymal transition (EMT) of gastric cancer cells after indicated transfection were detected by Cell counting kit-8 (CCK-8) assay, 5-ethynyl-2’-deoxyuridine (EdU) staining, wound healing assay, and transwell assay. The interaction between ISLR and MGAT5 was confirmed by co-immunoprecipitation. The expression of proteins related to migration, invasion, and EMT was detected by immunofluorescence and western blot.Results: As a result, ISLR was highly expressed in gastric cancer and was associated with poor prognosis. Interference with ISLR inhibited the viability, proliferation, migration, invasion, and EMT of gastric cancer cells. ISLR interacted with MGAT5 in gastric cancer cells. MGAT5 overexpression weakened the effects of ISLR knockdown on suppressing the viability, proliferation, migration, invasion, and EMT of gastric cancer cells.Conclusion: ISLR interacted with MGAT5 to promote the malignant progression of gastric cancer

Active and passive full-space collaborative control technology and engineering application in deep roadways

Due to the complex environment and ground stress at depth, and the various cross-sectional shapes and sizes, the damage types of deep roadways are diversified. The maximum ground stress, maximum compressive strength, and the corresponding support methods are compared by systematically analyzing the influence of high stress and dynamic pressure on the deep weak surrounding rock of roadways. And the stress intensity ratio is proposed to evaluate the support difficulty of surrounding rock of roadways. Then, the concept of active-passive full space collaborative control is proposed, and the core of the concept is to control the deformation of the roadway through active support methods such as destressing, grouting and bolt-cable to bring the self-supporting capacity of the surrounding rock of roadway into play, forming an active support body, and restoring its partial bearing capacity. Using passive support methods such as concrete-filled steel tube sets and U-shaped steel sets with high support resistance to form a passive support ring to assist or mobilize the bearing capacity of the rock surrounding roadways. Additionally, the mechanical mechanism of the collaborative support for concrete-filled steel tube sets and bolt-cable were analyzed, and the active-passive full space collaborative control technology and construction technique were developed and applied in the field. The study shows that the bolt-cable can reduce the bending moment and shear force of the concrete-filled steel tube sets, while reducing the axial force of the support and protecting the steel tube and the core concrete with poor tensile properties. The active-passive full space cooperative control technology has been successfully applied in deep roadway subjected to dynamic pressure and weak rock roadway in Jincheng Hudi Coal Mine and Yangquan Xinyuan Coal Mine, which has further developed the theory and technology of equal-strength support in deep roadway