Subjective Sleepiness Dynamics Dataset (SSDD) Presentation: the Study of Two Scales Consistency

While the first references to the system of sleepiness assessment are associated with medical re-search and the study of the effects of drugs on sleep, currently subjective sleepiness assessment is widely used across fundamental and practically oriented studies. The Stanford Sleepiness Scale (SSS) and the Karolinska Sleepiness Scale (KSS) are often used as ground truth in sleepiness re-search. Only a few studies applied both scales and practically none aimed at studying their con-sistency and specific features. The present study is devoted to analyzing the dynamics and con-sistency of subjective sleepiness as measured by the KSS and the SSS in the adult population. A particular task of the paper is to present the Subjective Sleepiness Dynamics Dataset (SSDD) with the evening and morning dynamics of situational subjective sleepiness. A total of 208 adults took part in the experiment. The results of the study revealed that sleepiness generally increased from evening till night and was maximal at early morning. The SSS score appeared to be more sensitive to some factors (e.g., the presence of sleep problems). The SSS and KSS scores were strongly consistent with each other. The KSS showed a generally more even distribution than the SSS. SSDD continues to be collected, we are going to equalize the sample by sex, we are actively adding older people. We plan to collect a sample of 1,000 people. Currently SSDD contains a lot of in-formation that can be used for scientific research.Comment: 18 pages, 6 figures, 3 table

THE CLINICAL COURSE OF RHEUMATOID ARTHRITIS IN KAZAKHSTANI PATIENTS

BACKGROUND: Rheumatoid arthritis (RA) prevalence according to the worldwide epidemiological data varies from 0.4% to 1.3%. The disability and mortality rate in RA is high. RA clinic is various, and compiles from articular and systemic manifestations.AIM: The aim of our study was to investigate the clinical course of RA in Kazakhstani patients living in North region of our country.METHODS: The 81 women at the age of 30–55 years with a verified diagnosis of RA who have lived in Kazakhstan for at least 10 years were recruited to the study. All participants were examined by the rheumatologist and a standard laboratory examination was carried out. Statistical analysis was conducted in IBM SPSS Statistics 26 software (IBM.USA;1).RESULTS: The statistically significant higher frequency of erosive radiological stages, bone ankylosis (χ2 = 18.070 df = 6 p = 0.005) was found in seropositive (rheumatoid factor [RF]+) anti-citrullinated protein/peptide antibody positive (ACPA+) subgroup. The correlation analysis showed strong association between certain RA form activity and inflammatory markers, as well as disease triggers. The discriminant model which predicts the stage of radiological damage was obtained. The sensitivity of model in predicting X-ray Stage I-71.6%, Stage II-29.4%, Stage III-37.5%, and Stage IV-63.6%.CONCLUSION: The debut of the RA on average occurred in the third decade of the patients’ life. The joint syndrome had a more unfavorable character RF+ACPA+ patients’ subgroup; however, RF+ACPA-negative (ACPA-) subgroup also showed a predisposition to poorer prognosis. The obtained discriminant model may be useful for RA patients’ managemen