5,998 research outputs found

    Mirror-orientation noise in a Fabry-Perot interferometer gravitational wave detector

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    The influence of angular mirror-orientation errors on the length of a Fabry-Perot resonator is analyzed geometrically. Under conditions in which dominant errors are static or vary slowly over time, the analysis permits a simple prediction of the spectrum of short-term cavity length fluctuations resulting from mirror-orientation noise. The resulting model is applicable to the design of mirror control systems for the Laser Interferometer Gravitational-Wave Observatory, which will monitor separations between mirrored surfaces of suspended inertial test bodies as a way to measure astrophysical gravitational radiation. The analysis is verified by measuring the response of the Laser Interferometer Gravitational- Wave Observatory's 40-m interferometer test-bed to the rotation of its mirrors

    Supersymmetric Brane World Scenarios from Off-Shell Supergravity

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    Using N=2 off-shell supergravity in five dimensions, we supersymmetrize the brane world scenario of Randall and Sundrum. We extend their construction to include supersymmetric matter at the fixpoints.Comment: 15 pages, no figures, late

    Lp-cohomology of negatively curved manifolds

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    We compute the LpL^p-cohomology spaces of some negatively curved manifolds. We deal with two cases: manifolds with finite volume and sufficiently pinched negative curvature, and conformally compact manifolds

    Vacuum energy for the supersymmetric twisted D-brane in constant electromagnetic field

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    We calculate vacuum energy for twisted SUSY D-brane on toroidal background with constant magnetic or constant electric field. Its behaviour for toroidal D-brane (p=2) in constant electric field shows the presence of stable minimum for twisted versions of the theory. That indicates such a background maybe reasonable groundstate.Comment: LaTeX, 10 page

    Bilirubin acts as an endogenous regulator of inflammation by disrupting adhesion molecule-mediated leukocyte migration

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    There is a growing body of evidence that bilirubin, which is generated during the physiological breakdown of heme, exerts potent anti-inflammatory effects.  Previous work by our group suggests that bilirubin is able to suppress inflammatory responses by preventing the migration of leukocytes into target tissues through disruption of vascular cell adhesion molecule-1 (VCAM-1)-dependent cell signaling. As VCAM-1 is an important mediator of tissue injury in the dextran sodium sulfate (DSS) murine model of inflammatory colitis, we examined whether bilirubin prevents colonic injury in DSS-treated mice. As anticipated, bilirubin-treated animals manifested significantly less colonic injury and reduced infiltration of inflammatory cells into colon tissues. We further observed that bilirubin administration was associated with a reduced number of eosinophils and monocytes in the small intestine, with a corresponding increase in peripheral blood eosinophilia, regardless of whether mice received DSS. These findings suggest that bilirubin impairs the normal migration of eosinophils into intestinal tissues, as supported by in vitro experiments showing that bilirubin blocks the VCAM-1-dependent movement of Jurkat cells across human endothelial cell monolayers. Taken together, our findings support that bilirubin ameliorates DSS-induced colitis and disrupts the physiological trafficking of leukocytes to the intestine by preventing transmigration across the vascular endothelium, potentially through the inhibition VCAM-1-mediated signaling. Our findings raise the possibility that bilirubin functions as an endogenous regulator of inflammatory responses

    A Search for Planetary Nebulae With the SDSS: the outer regions of M31

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    We have developed a method to identify planetary nebula (PN) candidates in imaging data of the Sloan Digital Sky Survey (SDSS). This method exploits the SDSS' five-band sampling of emission lines in PN spectra, which results in a color signature distinct from that of other sources. Selection criteria based on this signature can be applied to nearby galaxies in which PNe appear as point sources. We applied these criteria to the whole area of M31 as scanned by the SDSS, selecting 167 PN candidates that are located in the outer regions of M31. The spectra of 80 selected candidates were then observed with the 2.2m telescope at Calar Alto Observatory. These observations and cross-checks with literature data show that our method has a selection rate efficiency of about 90%, but the efficiency is different for the different groups of PNe candidates. In the outer regions of M31, PNe trace different well-known morphological features like the Northern Spur, the NGC205 Loop, the G1 Clump, etc. In general, the distribution of PNe in the outer region 8<R<20 kpc along the minor axis shows the "extended disk" - a rotationally supported low surface brightness structure with an exponential scale length of 3.21+/-0.14 kpc and a total mass of ~10^10 M_{\sun}, which is equivalent to the mass of M33. We report the discovery of three PN candidates with projected locations in the center of Andromeda NE, a very low surface brightness giant stellar structure in the outer halo of M31. Two of the PNe were spectroscopically confirmed as genuine PNe. These two PNe are located at projected distances along the major axis of ~48 Kpc and ~41 Kpc from the center of M31 and are the most distant PNe in M31 found up to now.Comment: 58 pages, 17 figures, 2 tables, Accepted to Astronomical Journa

    Leo V: A Companion of a Companion of the Milky Way Galaxy

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    We report the discovery of a new Milky Way dwarf spheroidal galaxy in the constellation of Leo identified in data from the Sloan Digital Sky Survey. Leo V lies at a distance of about 180 kpc, and is separated by about 3 degrees from another recent discovery, Leo IV. We present follow-up imaging from the Isaac Newton Telescope and spectroscopy from the Hectochelle fiber spectrograph at the Multiple Mirror Telescope. Leo V's heliocentric velocity is 173.4 km/s, which is offset by about 40 km/s from that of Leo IV. A simple interpretation of the kinematic data is that both objects may lie on the same stream, though the implied orbit is only modestly eccentric (e = 0.2)Comment: Submitted to ApJ (Letters
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