Rapamycin attenuates acute seizure-induced astrocyte injury in mice in vivo

AbstractAstrocytes have been implicated in epileptogenesis and seizure-induced brain injury. Pathological studies reveal a variety of structural abnormalities in astrocytes, such as vacuolization and astrogliosis. While in vivo imaging methods have demonstrated rapid changes in astrocytes under a variety of physiological and pathological conditions, the acute effects of seizures on astrocyte morphology in vivo and corresponding mechanisms of seizure-induced astrocytic injury have not been documented. In this study, we utilized in vivo two-photon imaging to directly monitor the acute structural effects of kainate-induced seizures on cortical astrocytes. Kainate seizures cause an immediate, but transient, vacuolization of astrocytes, followed over several days by astrogliosis. These effects are prevented by pre- or post-treatment with rapamycin, indicating the mTOR pathway is involved in mediating seizure-induced astrocyte injury. These finding have clinical implications for mechanisms of seizure-induced astrocyte injury and potential therapeutic applications with mTOR inhibitors.</jats:p

Energy Efficiency of Network Cooperation for Cellular Uplink Transmissions

There is a growing interest in energy efficient or so-called "green" wireless communication to reduce the energy consumption in cellular networks. Since today's wireless terminals are typically equipped with multiple network access interfaces such as Bluetooth, Wi-Fi, and cellular networks, this paper investigates user terminals cooperating with each other in transmitting their data packets to a base station (BS) by exploiting the multiple network access interfaces, referred to as inter-network cooperation, to improve the energy efficiency in cellular uplink transmission. Given target outage probability and data rate requirements, we develop a closed-form expression of energy efficiency in Bits-per-Joule for the inter-network cooperation by taking into account the path loss, fading, and thermal noise effects. Numerical results show that when the cooperating users move towards to each other, the proposed inter-network cooperation significantly improves the energy efficiency as compared with the traditional non-cooperation and intra-network cooperation. This implies that given a certain amount of bits to be transmitted, the inter-network cooperation requires less energy than the traditional non-cooperation and intra-network cooperation, showing the energy saving benefit of inter-network cooperation.Comment: in Proceedings of the 2013 IEEE International Conference on Communications (IEEE ICC 2013), Budapest, Hungary, June 201

A Survey on Wireless Security: Technical Challenges, Recent Advances and Future Trends

This paper examines the security vulnerabilities and threats imposed by the inherent open nature of wireless communications and to devise efficient defense mechanisms for improving the wireless network security. We first summarize the security requirements of wireless networks, including their authenticity, confidentiality, integrity and availability issues. Next, a comprehensive overview of security attacks encountered in wireless networks is presented in view of the network protocol architecture, where the potential security threats are discussed at each protocol layer. We also provide a survey of the existing security protocols and algorithms that are adopted in the existing wireless network standards, such as the Bluetooth, Wi-Fi, WiMAX, and the long-term evolution (LTE) systems. Then, we discuss the state-of-the-art in physical-layer security, which is an emerging technique of securing the open communications environment against eavesdropping attacks at the physical layer. We also introduce the family of various jamming attacks and their counter-measures, including the constant jammer, intermittent jammer, reactive jammer, adaptive jammer and intelligent jammer. Additionally, we discuss the integration of physical-layer security into existing authentication and cryptography mechanisms for further securing wireless networks. Finally, some technical challenges which remain unresolved at the time of writing are summarized and the future trends in wireless security are discussed.Comment: 36 pages. Accepted to Appear in Proceedings of the IEEE, 201