9,584 research outputs found
Rapamycin attenuates acute seizure-induced astrocyte injury in mice in vivo
AbstractAstrocytes have been implicated in epileptogenesis and seizure-induced brain injury. Pathological studies reveal a variety of structural abnormalities in astrocytes, such as vacuolization and astrogliosis. While in vivo imaging methods have demonstrated rapid changes in astrocytes under a variety of physiological and pathological conditions, the acute effects of seizures on astrocyte morphology in vivo and corresponding mechanisms of seizure-induced astrocytic injury have not been documented. In this study, we utilized in vivo two-photon imaging to directly monitor the acute structural effects of kainate-induced seizures on cortical astrocytes. Kainate seizures cause an immediate, but transient, vacuolization of astrocytes, followed over several days by astrogliosis. These effects are prevented by pre- or post-treatment with rapamycin, indicating the mTOR pathway is involved in mediating seizure-induced astrocyte injury. These finding have clinical implications for mechanisms of seizure-induced astrocyte injury and potential therapeutic applications with mTOR inhibitors.</jats:p
Energy Efficiency of Network Cooperation for Cellular Uplink Transmissions
There is a growing interest in energy efficient or so-called "green" wireless
communication to reduce the energy consumption in cellular networks. Since
today's wireless terminals are typically equipped with multiple network access
interfaces such as Bluetooth, Wi-Fi, and cellular networks, this paper
investigates user terminals cooperating with each other in transmitting their
data packets to a base station (BS) by exploiting the multiple network access
interfaces, referred to as inter-network cooperation, to improve the energy
efficiency in cellular uplink transmission. Given target outage probability and
data rate requirements, we develop a closed-form expression of energy
efficiency in Bits-per-Joule for the inter-network cooperation by taking into
account the path loss, fading, and thermal noise effects. Numerical results
show that when the cooperating users move towards to each other, the proposed
inter-network cooperation significantly improves the energy efficiency as
compared with the traditional non-cooperation and intra-network cooperation.
This implies that given a certain amount of bits to be transmitted, the
inter-network cooperation requires less energy than the traditional
non-cooperation and intra-network cooperation, showing the energy saving
benefit of inter-network cooperation.Comment: in Proceedings of the 2013 IEEE International Conference on
Communications (IEEE ICC 2013), Budapest, Hungary, June 201
A Survey on Wireless Security: Technical Challenges, Recent Advances and Future Trends
This paper examines the security vulnerabilities and threats imposed by the
inherent open nature of wireless communications and to devise efficient defense
mechanisms for improving the wireless network security. We first summarize the
security requirements of wireless networks, including their authenticity,
confidentiality, integrity and availability issues. Next, a comprehensive
overview of security attacks encountered in wireless networks is presented in
view of the network protocol architecture, where the potential security threats
are discussed at each protocol layer. We also provide a survey of the existing
security protocols and algorithms that are adopted in the existing wireless
network standards, such as the Bluetooth, Wi-Fi, WiMAX, and the long-term
evolution (LTE) systems. Then, we discuss the state-of-the-art in
physical-layer security, which is an emerging technique of securing the open
communications environment against eavesdropping attacks at the physical layer.
We also introduce the family of various jamming attacks and their
counter-measures, including the constant jammer, intermittent jammer, reactive
jammer, adaptive jammer and intelligent jammer. Additionally, we discuss the
integration of physical-layer security into existing authentication and
cryptography mechanisms for further securing wireless networks. Finally, some
technical challenges which remain unresolved at the time of writing are
summarized and the future trends in wireless security are discussed.Comment: 36 pages. Accepted to Appear in Proceedings of the IEEE, 201
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