Nonlinear consolidation of arbitrary layered soil with continuous drainage boundary: An approximate closed-form solution

Based on the double nonlinear consolidation constitutive associated with the compression and permeability coefficients, presented by Mesri and Rokhsar (1974), this paper derives an approximate closed-form solution for the one-dimensional nonlinear consolidation of the arbitrary layered soils incorporating the continuous drainage boundary condition. The approximate closed-form solution is obtained by the homogenization of the boundary conditions and eigenfunction method. A model test is conducted to justify the rationality of the approximation and the continuous drainage condition utilized in this study. The calculated results are also compared with those acquired from the simplified analytical solution and the finite difference method. A parametric study is conducted to investigate the influence of various parameters on the consolidation process. The most significant finding is that the influence of Nq appears to be completely different for the cases when Cc/Ck>1 and Cc/Ck1, the increase of Nq shows an adverse influence on the consolidation, whereas the influence becomes positive when Cc/Ck<1. The approximate solution derived herein offers a rigorous analytical approach for the double nonlinear consolidation problems of arbitrary layered soils, providing an effective benchmark for comparison and verification of future sophisticated numerical approaches

Emerging Mutual Regulatory Roles between m⁶A Modification and microRNAs

N6-metyladenosine (m6A), one of the most common RNA methylation modifications in mammals, has attracted extensive attentions owing to its regulatory roles in a variety of physiological and pathological processes. As a reversible epigenetic modification on RNAs, m6A is dynamically mediated by the functional interplay among the regulatory proteins of methyltransferases, demethylases and methyl-binding proteins. In recent years, it has become increasingly clear that m6A modification is associated with the production and function of microRNAs (miRNAs). In this review, we summarize the specific kinds of m6A modification methyltransferases, demethylases and methyl-binding proteins. In particular, we focus on describing the roles of m6A modification and its regulatory proteins in the production and function of miRNAs in a variety of pathological and physiological processes. More importantly, we further discuss the mediating mechanisms of miRNAs in m6A modification and its regulatory proteins during the occurrence and development of various diseases