Thermal analysis of SC quadrupoles in accelerator interaction regions

This paper presents results of a thermal analysis and operation margin calculation performed for NbTi and Nb{sub 3}Sn low-beta quadrupoles in collider interaction regions. Results of the thermal analysis for NbTi quadrupoles are compared with the relevant experimental data. An approach to quench limit measurements for Nb{sub 3}Sn quadrupoles is discussed

Design study of 2-in-1 large aperture ir dipole (D2) for the LHC luminosity upgrade

This paper analyses possible D2 magnet designs for the 'dipole-first' option of the LHC luminosity upgrade based on Nb3Sn superconductor and compares them in terms of the maximum field, field quality, and Lorentz forces in the coils

Single-layer high field dipole magnets

Fermilab is developing high field dipole magnets for post-LHC hadron colliders. Several designs with a nominal field of 10-12 T, coil bore size of 40-50 mm based on both shell-type and block-type coil geometry are currently under consideration. This paper presents a new approach to magnet design, based on simple and robust single-layer coils optimized for the maximum field, good field quality and minimum number of turns

Tick-Borne Encephalitis with Hemorrhagic Syndrome, Novosibirsk Region, Russia, 1999

Eight fatal cases of tick-borne encephalitis with unusual hemorrhagic syndrome were identified in 1999 in the Novosibirsk Region, Russia. To study these strains, we sequenced cDNA fragments of protein E gene from six archival formalin-fixed brain samples. Phylogenetic analysis showed tick-borne encephalitis variants clustered with a Far Eastern subtype (homology 94.7%) but not with the Siberian subtype (82%)

Study of high field superconducting solenoids for muon beam cooling

The final beam cooling stages of a possible Muon Collider may require DC solenoid magnets with magnetic fields of 40-50 T in an aperture of 40-50 mm. In this paper we study possible solutions towards creating DC fields of that order using available superconductors. Several magnetic and mechanical designs, optimized for the maximum performance are presented and compared in terms of cost and size

Asymptomatic cholelithiasis in bariatric practice

Background: The need for simultaneous cholecystectomy for asymptomatic cholelithiasis in patients undergoing bariatric intervention has not been proven. The experience of managing patients with obesity and concomitant disease cholelithiasis is presented. Aim: to determine the indications for simultaneous cholecystectomy and bariatric surgery in the combination of morbid obesity and a asymptomatic cholelithiasis. Methods: The results of observation of 37 patients with initially asymptomatic cholelithiasis were analyzed: 27 patients underwent bariatric surgery and simultaneous cholecystectomy, and 10 patients underwent only bariatric surgery. The immediate and long-term results of the treatment, the quality of life of patients and the cost of the treatment were assessed. Results: During 12 months of the follow-up, none of the patients who underwent simultaneous cholecystectomy developed any complications. Of the 10 patients in the observation group, 3 were operated on. Two patients underwent laparoscopic cholecystectomy for acute cholecystitis and one patient was operated on for choledocholithiasis with obstructive jaundice. The greatest improvement in the quality of life was observed in the gastric bypass group with simultaneous cholecystectomy. The treatment cost per patient was lower in that group, too. Conclusion: In the presence of asymptomatic cholelithiasis in a patient with morbid obesity, bariatric intervention and simultaneous cholecystectomy prevents the development of complications of cholelithiasis and thereby potentially improves the quality of life and reduces the cost of medical care

Superconducting helical solenoid systems for muon cooling experiment at Fermilab

Novel configurations of superconducting magnet system for Muon Beam Cooling Experiment is under design at Fermilab. The magnet system has to generate longitudinal and transverse dipole and quadrupole helical magnetic fields providing a muon beam motion along helical orbit. It was found that such complicated field configuration can be formed by a set of circular coils shifted in transverse directions in such a way that their centers lay on the center of the helical beam orbit. Closed beam orbit configurations were also proposed and investigated. This paper describes the magnetic and mechanical designs and parameters of such magnetic system based on a NbTi Rutherford type cable. The helical solenoid fabrication, assembly and quench protection issues are presented

The GWAS-MAP|ovis platform for aggregation and analysis of genome-wide association study results in sheep.

peer reviewedIn recent years, the number of genome-wide association studies (GWAS) carried out for various economically important animal traits has been increasing. GWAS discoveries provide summary statistics that can be used both for targeted marker-oriented selection and for studying the genetic control of economically important traits of farm animals. In contrast to research in human genetics, GWAS on farm animals often does not meet generally accepted standards (availability of information about effect and reference alleles, the size and direction of the effect, etc.). This greatly complicates the use of GWAS results for breeding needs. Within the framework of human genetics, there are several technological solutions for researching the harmonized results of GWAS, including one of the largest, the GWAS-MAP platform. For other types of living organisms, including economically important agricultural animals, there are no similar solutions. To our knowledge, no similar solution has been proposed to date for any of the species of economically important animals. As part of this work, we focused on creating a platform similar to GWAS-MAP for working with the results of GWAS of sheep, since sheep breeding is one of the most important branches of agriculture. By analogy with the GWAS-MAP platform for storing, unifying and analyzing human GWAS, we have created the GWAS-MAP|ovis platform. The platform currently contains information on more than 34 million associations between genomic sequence variants and traits of meat production in sheep. The platform can also be used to conduct colocalization analysis, a method that allows one to determine whether the association of a particular locus with two different traits is the result of pleiotropy or whether these traits are associated with different variants that are in linkage disequilibrium. This platform will be useful for breeders to select promising markers for breeding, as well as to obtain information for the introduction of genomic breeding and for scientists to replicate the results obtained.В последние годы увеличивается количество полногеномных исследований ассоциаций (ПГИА, GWAS), проведенных для различных экономически важных признаков животных. Результаты этих исследований представлены в виде суммарных статистик, которые можно использовать для изучения генетического контроля экономически важных признаков сельскохозяйственных животных, в том числе и при разработке методик маркер-ориентированной селекции. В большинстве случаев ПГИА сельскохозяйственных животных не соответствуют общепринятым в области исследований генетики человека стандартам формата публикаций результатов ПГИА в виде суммарных статистик (наличие информации об эффекторном и референсном аллелях, значение и направление эффекта и др.). Это существенно затрудняет использование суммарных статистик для нужд селекции. В области исследований генетики человека имеется несколько технологических решений для анализа результатов ПГИА, в том числе одно из самых крупных – платформа GWAS-MAP. Для других видов живых организмов, включающих и экономически важных сельскохозяйственных животных, подобных решений нет. В настоящей работе мы сфокусировались на создании схожей платформы для работы с суммарными статистиками ПГИА различных признаков овец, так как овцеводство в последнее время становится все более актуальной областью сельского хозяйства. По аналогии с платформой GWAS-MAP для хранения, унификации и анализа GWAS человека мы создали платформу GWAS-MAP|ovis. На сегодняшний день платформа содержит информацию о более чем 34 млн ассоциаций между вариантами геномной последовательности и признаками мясной продуктивности. Платформа может быть использована и для проведения анализа колокализации – метода, который позволяет установить, является ли ассоциация определенного локуса с двумя разными признаками результатом плейотропии или же данные признаки ассоциированы с разными вариантами, которые находятся в неравновесии по сцеплению. Эта платформа будет полезна как селекционерам для выбора перспективных маркеров для селекции (эффекты и аллели различных маркеров, влияющих на изучаемые признаки), так и для ученых, ведущих исследования в области генетики овец