10 research outputs found
Prevalence, prognosis and the possibilities of prevention of ulcus cruris
Tijekom 1999. godine na Odjelu za kožne i spolne bolesti KliniÄke bolnice Osijek pregledano je 185 bolesnika s ulkusom potkoljenice: 72,43% bile su žene, a 27,57% muÅ”karci. Na bolniÄkom lijeÄenju iste je godine bilo 137 bolesnika, Å”to Äini 26,39% ukupnog broja bolniÄki lijeÄenih bolesnika. ProsjeÄna je dužina boravka na odjelu bolesnika s ulkusom bila 17,6 dana, a broj dana provedenih na lijeÄenju je iznosio ukupno 2423. LijeÄenje ulkusa predstavlja uglavnom veliki problem, financijski zahtjevan.During 1999. 185 patients with ulcus cruris were examined at the Department of Dermatovenerology, Osijek Clinical Hospital. 72.43% were females and 27.57% males. 137 patients were hospitalized which is 26,39% of all hospitalized patients. The average length of hospitalisation for those patients was 17.6 days. The total number of hospital days for patients with ulcus cruris was 2423. The management of ulcus cruris mostly presents a great problem and involves high cost
Prevalence and basic characteristic of psoriasis vulgaris in the city of Osijek
Terenskim istraživanjem obuhvaÄeno je na podruÄju grada Osijeka 300 stanovnika, sa ciljem da se ustanovi prevalencija psoriasis vulgaris (PV). Vulgarna psorijaza je dijagnosticirana u 44 ispitanika (20 žena i 24 muÅ”karca), Å”to predstavlja prevalenciju od 1,46 % i odnos od 1,2:1 na Å”tetu muÅ”karaca. Kod žena se bolest javlja neÅ”to ranije, i to najviÅ”e u periodu do 20 godina života, a kod muÅ”karaca izmeÄu 20 ā 29-te godine. Pozitivni anamnestiÄki podaci o postojanju PV nekog od Älanova obitelji, dobiveni u 27,3 % psorijatiÄnih bolesnika, ukazuju da genetsko optereÄenje igra znaÄajnu ulogu u kliniÄkoj ekspresiji bolesti.A field investigation, aiming to establish the prevalence of Psoriasis vulgaris (PV) in the city of Osijek, included 3000 inhabitants. The disease was diagnosed in 44 examinees (20 females and 24 males), i.e. the prevalence is 1.46%, with the relation of 1.2:1 to the benefit of the females. Females develop the disease somewhat earlier, mostly before the age of 20, whereas in males it appears between the ages of 20 and 29. Positive family history of PV, obtained in 27.3 % of the patients, suggests an important role of genetic load in the clinical expression of the disease
GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF PSORIASIS
Hrvatsko dermatoveneroloÅ”ko druÅ”tvo Hrvatskoga lijeÄniÄkog zbora ustrojilo je radnu skupinu vodeÄih hrvatskih struÄnjaka koji se bave psorijazom. Radna je skupina kritiÄki prouÄila mjerodavnu znanstvenu literaturu te donijela smjernice za dijagnostiku i lijeÄenje psorijaze.Croatian dermatovenerological society of the Croatian Medical Association formed the working group which consists of leading experts for psoriasis in Croatia. After a critical analysis of relevant scientific papers, the working group has developed guidelines for the diagnosis and treatment of psoriasi
Epidemiology of Dermatomycosis in the Eastern Croatia ā Today and Yesterday
The aim of our investigation was to compare the distribution of dermatomycosis species
in Eastern Croatia between two different periods: first period from 1997ā2001 year,
and second period from 1986ā88 year. The outpatients from Department of Dermatovenerology
University Hospital Ā»OsijekĀ« with confirmed diagnosis infection Tinea, were
selected on the basis o age, gender, localization and dermatomycosis species. During the
first period (1997ā2001) among 75,691 outpatients Tinea infection was confirmed in
558 (0.73%), while in the second period among 47,832 outpatients there were 126
(0.26%) cases with Tinea, what showed significant increase of fungal infections among
population this region. According the age and gender in both periods predominant population
were under of the age 16 (40.14%: 41.26%), and female population was predominant
(58.60% and 57.14%) in comparison to males (41.39% and 42.85%). The most frequent
localization of lesions in period I were cutis glabrae (47.31%), palms and soles
(31.36%), capitis (17.38%) and unguis (9.31%) and isolated species were as followed:
Trichophyton (39.06%), Microsporum (31.72%) and Candida (28.13%) species. In period
II the most frequent localization were palms and soles (40.47%), cutis glabrae (36.50%),
capitis (12.69%) and unguis (10.31%). The isolated species in this period were: Trichophyton
(80.15%), Candida (12.69%) and Microsporum (4.76%) species. From the data
collected during two different periods we can observe 1) increase of fungal infection generally
in our region; 2) significant changes in causative species (increase of Microsporum
and Candida species infection, but Trichophyton spp still remain the first causative
agent); and 3) changes in the localization of lesions
Smjernice za dijagnostiku i lijeÄenje vulgarne psorijaze [Guidelines for the diagnosis and treatment of psoriasis]
Croatian dermatovenerological society of the Croatian Medical Association formed the working group which consists of leading experts for psoriasis in Croatia. After a critical analysis of relevant scientific papers, the working group has developed guidelines for the diagnosis and treatment of psoriasis
Antisynthetase syndrome - a case report
U dvadesetosmogodiÅ”nje bolesnice s dominirajuÄim znacima polimiozitisa i zahvaÄanjem pluÄnog intersticija s pozitivnim nalazom anti-Jo1 protutijela postavljena je sumnja na antisintetaza sindrom. Tijekom sljedeÄa tri mjeseca pojavile su se ragade i ulceracije na vrÅ”cima prstiju. U kasnijem tijeku bolesti javila se slika mijeÅ”ane bolesti vezivnog tkiva udružene s intersticijskom pluÄnom bolesti uz dominirajuÄu sliku sistemske skleroze. LijeÄena je glukokortikoidima uz imunosupresivnu terapiju na koju je stanje uglavnom bilo stabilno, bez znaÄajnije progresije pluÄnih promjena. Rana dijagnoza i lijeÄenje antisintetaza sindroma utjeÄu na povoljniji tijek i ishod bolesti. Preduvjet za navedeno su dobro definirani dijagnostiÄki kriteriji uz procjenu stanja i adekvatan izbor terapije.Twenty-eight year-old woman with predominant signs of polymyositis, pulmonary interstitium involvement and with positive anti-Jo1 antibodies was suspected for antisynthetase syndrome. Over the next three months sores and ulcerations have appeared at the fingertips. In the later course of the disease clinical picture of mixed connective tissue disease associated with interstitial lung disease, with a dominant picture of systemic sclerosis have emerged. She was treated with glucocorticoides and immunosuppressive therapy. Patient condition was mostly stable, without significant progression of lung lesions. Early diagnosis and treatment antisynthetase syndrome significantly contributes to more favorable course and outcome of disease. A prerequisite for that are well-defined diagnostic criteria and an appropriate choice of treatment
GUIDELINES FOR DIAGNOSIS, THERAPY AND FOLLOW UP OF ANDERSON-FABRY DISEASE
Fabryjeva bolest (Anderson-Fabryjeva bolest) jedna je od najÄeÅ”Äih lizosomskih bolesti nakupljanja (nakon Gaucherove bolesti) uzrokovana smanjenom aktivnoÅ”Äu enzima Ī±-galaktosidaze A (Ī± -Gal A) uz posljediÄno nakupljanje globotriaozilceramida u razliÄitim stanicama, ponajprije u endotelnim i vaskularnim glatkim miÅ”iÄnim stanicama uz posljediÄne multisistemske manifestacije. Pojavnost bolesti u muÅ”karaca je 1:40.000-60.000, dok je u opÄoj populaciji oko 1 : 117.000. Bol je najÄeÅ”Äe prvi simptom bolesti u 60-80 % djece, kao i simptomi probavnog sustava, oftalmoloÅ”ki simptomi, gubitak sluha. Smanjenje bubrežne funkcije, hipertrofiÄna miokardiopatija ili moždani udar mogu se iskazati kao izolirani simptomi bolesti. U bolesnika s Fabryjevom boleÅ”Äu skraÄuje se oÄekivani životni vijek i to u muÅ”karaca za oko 20 godina, a u žena za 10-15 godina, pa je stoga uvoÄenje nadomjesne enzimske terapije nužno u svih bolesnika koji zadovoljavaju kriterije za terapiju ove bolesti bez obzira na dob i spol.Fabry disease (Anderson-Fabry disease) is one of the most common lysosomal storage diseases (after Gaucher disease) caused by deficient activity of the Ī±-galactosidase A (Ī±-Gal A) enzyme, which leads to progressive accumulation of globotriaosylceramide in various cells, predominantly in endothelium and vascular smooth muscles, with multisystem clinical manifestations. Estimates of the incidence range from one per 40,000 to 60,000 in males, and 1:117,000 in the general population. Pain is usually the first symptom and is present in 60%-80% of affected children, as well as gastrointestinal disturbances, ophthalmologic abnormalities and hearing loss. Renal failure, hypertrophic cardiomyopathy, or stroke as the presenting symptom may also be found even as isolated symptoms of the disease. Life expectancy is reduced by approximately 20 years in males and 10-15 years in females, therefore enzyme replacement therapy should be introduced in patients of any age and either sex, who meet treatment criteria for Anderson-Fabry disease
Smjernice za dijagnosticiranje, terapiju i praÄenje Anderson-Fabryjeve bolesti
Fabry disease (Anderson-Fabry disease) is one of the most common lysosomal storage diseases (after Gaucher disease) caused by deficient activity of the Ī±-galactosidase A (Ī±-Gal A) enzyme, which leads to progressive accumulation of globotriaosylceramide in various cells, predominantly in endothelium and vascular smooth muscles, with multisystem clinical manifestations. Estimates of the incidence range from one per 40,000 to 60,000 in males, and 1:117,000 in the
general population. Pain is usually the first symptom and is present in 60%-80% of affected children, as well as gastrointestinal disturbances, ophthalmologic abnormalities and hearing loss. Renal failure, hypertrophic cardiomyopathy, or stroke as the presenting symptom may also be found even as isolated symptoms of the disease. Life expectancy is reduced by approximately 20 years in males and 10-15 years in females, therefore enzyme replacement therapy should be introduced in patients of any age and either sex, who meet treatment criteria for Anderson-Fabry disease.Fabryjeva bolest (Anderson-Fabryjeva bolest) je jedna od najÄeÅ”Äih lizosomskih bolesti nakupljanja (nakon Gaucherove bolesti) uzrokovana smanjenom aktivnoÅ”Äu enzima Ī±-galaktosidaze A (Ī± -Gal A) uz posljediÄno nakupljanje globotriaozilceramida u razliÄitim stanicama, ponajprije u endotelnim i vaskularnim glatkim miÅ”iÄnim stanicama uz posljediÄne multisistemske manifestacije. Pojavnost bolesti u muÅ”karaca je 1:40.000-60.000, dok je u opÄoj populaciji oko 1:117.000. Bol je najÄeÅ”Äe prvi simptom bolesti u 60%-80% djece, kao i simptomi probavnog sustava, oftalmoloÅ”ki simptomi, gubitak sluha. Smanjenje bubrežne funkcije, hipertrofiÄna miokardiopatija ili moždani udar mogu se iskazati kao izolirani simptomi bolesti. OÄekivani životni vijek se skraÄuje u bolesnika s Fabryjevom boleÅ”Äu i to u muÅ”karaca za oko 20 godina, a u žena za 10-15 godina, stoga je uvoÄenje enzimske nadomjesne terapije nužno u svih bolesnika bez obzira na dob i spol koji zadovoljavaju kriterije za terapiju ove bolesti