Sensitivity of the Cherenkov Telescope Array to TeV photon emission from the Large Magellanic Cloud

A deep survey of the Large Magellanic Cloud at ∼0.1-100 TeV photon energies with the Cherenkov Telescope Array is planned. We assess the detection prospects based on a model for the emission of the galaxy, comprising the four known TeV emitters, mock populations of sources, and interstellar emission on galactic scales. We also assess the detectability of 30 Doradus and SN 1987A, and the constraints that can be derived on the nature of dark matter. The survey will allow for fine spectral studies of N 157B, N 132D, LMC P3, and 30 Doradus C, and half a dozen other sources should be revealed, mainly pulsar-powered objects. The remnant from SN 1987A could be detected if it produces cosmic-ray nuclei with a flat power-law spectrum at high energies, or with a steeper index 2.3-2.4 pending a flux increase by a factor of >3-4 over ∼2015-2035. Large-scale interstellar emission remains mostly out of reach of the survey if its >10 GeV spectrum has a soft photon index ∼2.7, but degree-scale 0.1-10 TeV pion-decay emission could be detected if the cosmic-ray spectrum hardens above >100 GeV. The 30 Doradus star-forming region is detectable if acceleration efficiency is on the order of 1−10 per cent of the mechanical luminosity and diffusion is suppressed by two orders of magnitude within <100 pc. Finally, the survey could probe the canonical velocity-averaged cross-section for self-annihilation of weakly interacting massive particles for cuspy Navarro-Frenk-White profiles

Sensitivity of the Cherenkov Telescope Array to a dark matter signal from the Galactic centre

We provide an updated assessment of the power of the Cherenkov Telescope Array (CTA) to search for thermally produced dark matter at the TeV scale, via the associated gamma-ray signal from pair-annihilating dark matter particles in the region around the Galactic centre. We find that CTA will open a new window of discovery potential, significantly extending the range of robustly testable models given a standard cuspy profile of the dark matter density distribution. Importantly, even for a cored profile, the projected sensitivity of CTA will be sufficient to probe various well-motivated models of thermally produced dark matter at the TeV scale. This is due to CTA's unprecedented sensitivity, angular and energy resolutions, and the planned observational strategy. The survey of the inner Galaxy will cover a much larger region than corresponding previous observational campaigns with imaging atmospheric Cherenkov telescopes. CTA will map with unprecedented precision the large-scale diffuse emission in high-energy gamma rays, constituting a background for dark matter searches for which we adopt state-of-the-art models based on current data. Throughout our analysis, we use up-to-date event reconstruction Monte Carlo tools developed by the CTA consortium, and pay special attention to quantifying the level of instrumental systematic uncertainties, as well as background template systematic errors, required to probe thermally produced dark matter at these energies

Sensitivity of the Cherenkov Telescope Array to a dark matter signal from the Galactic centre

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Observation of the Cumbre Vieja volcano plume above the Observatorio del Roque de los Muchachos with the Barcelona Raman LIDAR

The Cherenkov Telescope Array Observatory (CTAO), currently under construction, is the next-generation very-high-energy gamma-ray observatory, providing the coverage for photons in the energy range 20GeV to 300TeV. CTAO will increase detection sensitivity in the 100 GeV to 10TeV range by a factor of 5 - 10 with respect to present experiments. CTAO retrieves the properties of very-high-energy gamma-rays by measuring Cherenkov light emitted by atmospheric showers of secondary particles that incident gamma rays produce in upper layers of the atmosphere. The key for reaching the required energy measurement accuracy is a precise knowledge of the atmospheric transmittance for Cherenkov light, which can be obtained using a dedicated Raman LIDAR. The device should operate at 355nm (near the maximum of Cherenkov light spectrum) and have the capability of taking data at specific azimuth and zenith angles up to distances of 30 km, so that atmospheric transmission along all possible air-shower directions can be determined. The Barcelona Raman LIDAR (BRL) is the official CTAO Pathfinder prototype, developed for atmospheric characterization of the Northern CTAO Site at the Observatorio del Roque de los Muchachos (ORM) on the Canary island of La Palma. BRL was deployed at ORM for extensive on-field tests between February 2021 and May 2022. We report on the commissioning results, including the remote operation capabilities of the system and its contribution to the understanding of atmospheric phenomena during its deployment period. In particular, we report on the properties of the volcanic plume from the eruption of the Cumbre Vieja volcano on 22 September 2021

Noncovalent tripeptidyl benzyl- And cyclohexyl-amine inhibitors of the cysteine protease caspase-1

Potent and noncovalent inhibitors of caspase-1 were produced by incorporating a secondary amine (reduced amide) isostere in place of the conventional electrophile (e.g., aldehyde) that normally confers high potency to cysteine protease inhibitors. Benzyl- or cyclohexylamines produced potent, reversible, and competitive inhibitors that were selective for caspase-1 (e.g., K(i) = 47 nM) over caspases 3 and 8 with minimal cytotoxicity. Unlike most cysteine protease inhibitors, these compounds do not react covalently and indiscriminately with thiols