A Statistical Study of Soft X-ray Flares on Solar-type Stars

The statistical characteristic of stellar flares at optical bands has received an extensive study, but it remains to be studied at soft X-ray bands, in particular for solar-type stars. Here, we present a statistical study of soft X-ray flares on solar-type stars, which can help understand multi-wavelength behaviors of stellar flares. We mainly use Chandra Source Catalog Release 2.0, which includes a number of flaring stars with denoted variability, and Gaia Data Release 3, which includes necessary information for classifying stars. We also develop a set of methods for identifying and classifying stellar soft X-ray flares and estimating their properties. A detailed statistical investigation for 129 flare samples on 103 nearby solar-type stars as selected yields the following main results. (1) The flare energy emitted at the soft X-ray band in our sample ranges from $\sim 10^{33}$ to $\sim 10^{37} \ \mathrm{erg}$, and the majority of them are superflares with the most energetic one having energy of $6.0_{-4.7}^{+3.2} \times 10^{37} \ \mathrm{erg}$. (2) The flare duration is related to its energy as formulated by$T_\mathrm{duration,SXR} \propto E_\mathrm{flare,SXR}^{\ 0.201 \pm 0.024}$, which is different from those derived at optical and NIR bands, indicating distinct radiation mechanisms at different bands. (3) The frequency distribution of stellar flares as a function of energy is formulated as$\mathrm{d} N_\mathrm{flare} / \mathrm{d} E_\mathrm{flare,SXR} \propto E_\mathrm{flare,SXR}^{\ -1.77}$, which is similar to the results found at other bands and on other types of stars, indicating that the energy emitted at the soft X-ray band could be a constant fraction of the full-band bolometric energy

The Role of KLF4 in Alzheimer’s Disease

Krüppel-like factor 4 (KLF4), a member of the family of zinc-finger transcription factors, is widely expressed in range of tissues that play multiple functions. Emerging evidence suggest KLF4’s critical regulatory effect on the neurophysiological and neuropathological processes of Alzheimer’s disease (AD), indicating that KLF4 might be a potential therapeutic target of neurodegenerative diseases. In this review, we will summarize relevant studies and illuminate the regulatory role of KLF4 in the neuroinflammation, neuronal apoptosis, axon regeneration and iron accumulation to clarify KLF4’s status in the pathogenesis of AD

Recent Advances in Herbal Medicines for Digestive System Malignancies

Herbal medicines, as an important part of traditional Chinese medicine (TCM), have been used to treat digestive system malignancies (DSM) for many years, and have gradually gained recognition worldwide. The role of herbal medicines in the comprehensive treatment of DSM is being improved from adjuvant treatment of the autologous immune function in cancer patients, to the treatment of both the symptoms and disease, direct inhibition of tumor cell growth and proliferation, and induction of tumor cell autophagy and apoptosis. Their specific mechanisms in these treatments are also being explored. The paper reviews the current anti-tumor mechanisms of TCM, including single herbal medicines, Chinese herbal formulations, Chinese medicine preparations and TCM extract, and their application in the comprehensive treatment of digestive system tumors, providing a reference for clinical application of TCM

Igwas: Image-Based Genome-Wide Association of Self-Supervised Deep Phenotyping of Retina Fundus Images

Existing imaging genetics studies have been mostly limited in scope by using imaging-derived phenotypes defined by human experts. Here, leveraging new breakthroughs in self-supervised deep representation learning, we propose a new approach, image-based genome-wide association study (iGWAS), for identifying genetic factors associated with phenotypes discovered from medical images using contrastive learning. Using retinal fundus photos, our model extracts a 128-dimensional vector representing features of the retina as phenotypes. After training the model on 40,000 images from the EyePACS dataset, we generated phenotypes from 130,329 images of 65,629 British White participants in the UK Biobank. We conducted GWAS on these phenotypes and identified 14 loci with genome-wide significance (

Reconstructing Source-Sink Dynamics in a Population with a Pelagic Dispersal Phase

For many organisms, the reconstruction of source-sink dynamics is hampered by limited knowledge of the spatial assemblage of either the source or sink components or lack of information on the strength of the linkage for any source-sink pair. In the case of marine species with a pelagic dispersal phase, these problems may be mitigated through the use of particle drift simulations based on an ocean circulation model. However, when simulated particle trajectories do not intersect sampling sites, the corroboration of model drift simulations with field data is hampered. Here, we apply a new statistical approach for reconstructing source-sink dynamics that overcomes the aforementioned problems. Our research is motivated by the need for understanding observed changes in jellyfish distributions in the eastern Bering Sea since 1990. By contrasting the source-sink dynamics reconstructed with data from the pre-1990 period with that from the post-1990 period, it appears that changes in jellyfish distribution resulted from the combined effects of higher jellyfish productivity and longer dispersal of jellyfish resulting from a shift in the ocean circulation starting in 1991. A sensitivity analysis suggests that the source-sink reconstruction is robust to typical systematic and random errors in the ocean circulation model driving the particle drift simulations. The jellyfish analysis illustrates that new insights can be gained by studying structural changes in source-sink dynamics. The proposed approach is applicable for the spatial source-sink reconstruction of other species and even abiotic processes, such as sediment transport

Physiological and transcriptomic analysis reveal the crucial factors in heat stress response of red raspberry ‘Polka’ seedlings

With global climate warming, recurring extreme heat and high temperatures irreversibly damage plants. Raspberries, known for their nutritional and medicinal value, are in high demand worldwide. Thus, it is important to study how high-temperature stress (HTS) affects raspberries. The physiological and biochemical responses and molecular genetic mechanisms of raspberry leaves to different HTS treatments were investigated: mild high temperature at 35°C (HT35), severe high temperature at 40°C (HT40), and the control at room temperature of 25°C (CK). The physiological results suggested that leaves in both the 35°C and 40°C treatments showed maximum relative conductivity at 4 d of stress, increasing by 28.54% and 43.36%, respectively, compared to CK. Throughout the stress period (0–4 d), malondialdehyde (MDA) and soluble protein contents of raspberry leaves increased under HT35 and HT40 treatments, while soluble sugar content first decreased and then increased. Catalase (CAT) activity increased, superoxide dismutase (SOD) activity first increased and then decreased, and peroxidase (POD) activity gradually decreased. Photosynthetic and fluorescence responses of raspberry leaves showed the most severe impairment after 4 d of stress. Transcriptomics results revealed significant alterations in 42 HSP family genes, two SOD-related differentially expressed genes (DEGs), 25 POD-related DEGs, three CAT-related DEGs, and 38 photosynthesis-related DEGs under HTS. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that these DEGs were mainly enriched in photosynthesis-antenna proteins, pentose and glucuronide interconversion, phenylpropane biosynthesis, and indole alkaloid biosynthesis. HTS induced excessive ROS accumulation in raspberry leaves, causing oxidative damage in plant cells and subsequently reducing photosynthesis in raspberry leaves. This reduction in photosynthesis, in turn, affects photosynthetic carbon fixation and starch and sucrose metabolism, which, combined with phenol propane biosynthesis, mitigates the HTS-induced damage

Isolation and identification of Tete virus group (Peribunyaviridae: Orthobunyavirus) from Culicoides biting midges collected in Lichuan County, China

In July 2018, a virus (JXLC1806-2) was isolated from Culicoides biting midges collected in Lichuan County, Jiangxi Province, China. The virus isolate showed significant cytopathic effects within 48 hours after inoculation with mammalian cells (BHK-21). JXLC1806-2 virus could form plaques in BHK-21 cells, and the virus titer was 1×105.6 pfu/mL. After inoculation with the virus, suckling mice developed disease and died. The nucleotide and amino sequence analysis showed that the JXLC1806-2 virus genome was composed of S, M and L segments. Phylogenetic analysis showed that the S, M and L genes of JXLC1806-2 virus belonged to the Tete serogroup, Orthobunyavirus, but formed an independent evolutionary branch from the other members of the Tete serogroup. The results showed that the JXLC1806-2 virus, which was named as Lichuan virus, is a new member of Tete serogroup, and this is the first time that a Tete serogroup virus has been isolated in China

Tensile and Compressive Properties of Woven Fabric Carbon Fiber-Reinforced Polymer Laminates Containing Three-Dimensional Microvascular Channels

Microvascular self-healing composite materials have significant potential for application and their mechanical properties need in-depth investigation. In this paper, the tensile and compressive properties of woven fabric carbon fiber-reinforced polymer (CFRP) laminates containing three-dimensional microvascular channels were investigated experimentally. Several detailed finite element (FE) models were established to simulate the mechanical behavior of the laminate and the effectiveness of different models was examined. The damage propagation process of the microvascular laminates and the influence of microvascular parameters were studied by the validated models. The results show that microvascular channels arranged along the thickness direction (z-direction) of the laminates are critical locations under the loads. The channels have minimal effect on the stiffness of the laminates but cause a certain reduction in strength, which varies approximately linearly with the z-direction channel diameter within its common design range of 0.1~1 mm. It is necessary to consider the resin-rich region formed around microvascular channels in the warp and weft fiber yarns of the woven fabric composite when establishing the FE model. The layers in the model should be assigned with equivalent unidirectional ply material in order to calculate the mechanical properties of laminates correctly

Experimental and Numerical Investigation on Fatigue Properties of Carbon Fiber Cross-Ply Laminates in Hygrothermal Environments

The fatigue properties of composite materials are degraded seriously in hygrothermal environments, so taking into account their influence is very important when evaluating the fatigue life of composite structures. Tensile fatigue experiments of carbon fiber reinforced resin composite cross-ply laminates were conducted in room temperature/dry (RTD), cool temperature/dry (CTD) and elevated temperature/wet (ETW) conditions. The S-N curves and fatigue failure modes of the cross-ply laminates were obtained in three conditions. On this basis, a finite element model was established to discuss the influence of temperature and moisture content on the fatigue properties, as well as a method for determining environmental factors of fatigue life of cross-ply laminates was established. The results show that the saturation moisture absorption and temperature have a significant influence on the tensile fatigue properties of cross-ply laminates. The high-cycle fatigue property is weakened significantly by the saturation moisture absorption and high temperature, but the low-cycle fatigue properties were strengthened in cool temperature conditions. The delamination failure mode in ETW is the most severe, presenting with an obvious necking phenomenon. The influence of temperature has a greater effect than that of moisture content, but moisture absorption would play its affect obviously when temperature exceeds 40 °C