The Mediating Effect of Psychological Quality of Innovation and Entrepreneurship Education on Graduate Students' Innovation and Entrepreneurship Ability and Willingness

This work was supported by the Degree and Graduate Education Reform Key Projects of Guangdong Province, and the title is Exploration and Practice of Postgraduate Cultivation in Incorporating Innovation and Entrepreneurship Consciousness. Also, it was supported by the project of China Higher Education Association Thirteenth Five-Year Plan for Scientific Research in Higher Education (Grant number: 2018SYSZD08). Abstract Under the background of the innovation and entrepreneurship ability improvement plan proposed by the Ministry of education of China, the research on the subject of entrepreneurship and innovation is conducive to the continuous deepening of innovation and entrepreneurship education reform in Colleges and universities, and the continuous training and delivery of high-level talents for the construction of an innovative country. This paper explores the relationship among innovation and entrepreneurship ability, innovation and entrepreneurship education psychological quality and innovation and entrepreneurship willingness through a questionnaire survey of graduate students in Colleges and universities, analyzes the current situation, further confirms the hypothesis among the three, obtains positive results, and puts forward some countermeasures and suggestions for higher education. Keywords: Higher education, Graduate students, Willingness of innovation and entrepreneurship, Innovation and entrepreneurship ability, Psychological quality of innovation and entrepreneurship education DOI: 10.7176/JEP/11-19-06 Publication date:July 31st 202

Img2Loc: Revisiting Image Geolocalization using Multi-modality Foundation Models and Image-based Retrieval-Augmented Generation

Geolocating precise locations from images presents a challenging problem in computer vision and information retrieval.Traditional methods typically employ either classification, which dividing the Earth surface into grid cells and classifying images accordingly, or retrieval, which identifying locations by matching images with a database of image-location pairs. However, classification-based approaches are limited by the cell size and cannot yield precise predictions, while retrieval-based systems usually suffer from poor search quality and inadequate coverage of the global landscape at varied scale and aggregation levels. To overcome these drawbacks, we present Img2Loc, a novel system that redefines image geolocalization as a text generation task. This is achieved using cutting-edge large multi-modality models like GPT4V or LLaVA with retrieval augmented generation. Img2Loc first employs CLIP-based representations to generate an image-based coordinate query database. It then uniquely combines query results with images itself, forming elaborate prompts customized for LMMs. When tested on benchmark datasets such as Im2GPS3k and YFCC4k, Img2Loc not only surpasses the performance of previous state-of-the-art models but does so without any model training

Removing low-concentration methane via thermo-catalytic oxidation on CuOx/zeolite

Methane (CH 4) is the second most potent greenhouse gas that exists largely in low concentrations. This fact, coupled with its inert nature, brings both urgency and challenge for any mitigations (including thermo-catalytic oxidation). In this study, we address this challenge by synthesizing highly dispersed CuO x species (∼6 wt%) loaded on mordenite zeolite (MOR), and enhancing the catalytic performance for the thermal oxidation of low-concentration CH 4. The optimized sample, Cu-MOR-11, demonstrates exceptional catalytic properties, including high activity with 100 % CH 4 total oxidation to CO 2 at 400 °C, low reaction temperature with a T 10 at 230 °C and T 90 at 350 °C, as well as excellent long-term stability and reusability over a 100-hour reaction period. These attributes make it a promising candidate for large scale CH 4 oxidation applications. To elucidate the mechanisms behind the enhanced catalytic performance of Cu-MOR-11, we conclude, 1) the generation of more Brønsted acid sites which facilitated the absorption and dissociation of CH 4; 2) the presence of Al 3+ as acid sites in the MOR supports played a crucial role in achieving high CuO x species dispersion, acting as anchoring sites to effectively stabilize and disperse CuO x species, which provides more active sites; 3) variation in preparation environments (e.g., pH) led to different oxidation states of the catalysts, with alkaline conditions facilitating the deoxidation of CuO x species, resulting in more Cu +&amp;Cu 0 compared to CuO; 4) the presence of Brønsted acid sites which mitigated coking at low temperatures and prevented the loss of structural stability at high temperatures.</p

Tanshinone IIA pretreatment protects free flaps against hypoxic injury by upregulating stem cell-related biomarkers in epithelial skin cells

BACKGROUND: Partial or total flap necrosis after flap transplantation is sometimes encountered in reconstructive surgery, often as a result of a period of hypoxia that exceeds the tolerance of the flap tissue. The purpose of this study was to determine whether Tanshinone IIA (TSA) pretreatment can protect flap tissue against hypoxic injury and improve its viability. METHODS: Primary epithelial cells isolated from the dorsal skin of mice were pretreated with TSA for 2 weeks. Cell Counting Kit-8 and Trypan Blue assays were carried out to examine the proliferation of TSA-pretreated cells after exposure to cobalt chloride. Polymerase chain reaction and western blot analysis were used to assess the expression of β-catenin, vascular endothelial growth factor (VEGF), sex determining region Y-box 2 (SOX2), OCT4 (also known as POU domain class 5 transcription factor 1), Nanog, and glycogen synthase kinase-3 beta (GSK-3β) in TSA-treated cells. In other experiments, after mice were pretreated with TSA for 2 weeks, a reproducible ischemic flap model was implemented, and the area of surviving tissue in the transplanted flaps was measured. Immunohistochemistry was conducted to examine Wnt signaling as well as stem cell- and angiogenesis-related biomarkers in epithelial tissue in vivo. RESULTS: Epidermal cells, pretreated with TSA, showed enhanced resistance to hypoxia. Activation of the Wnt signaling pathway in TSA-pretreated cells was characterized by the upregulation of β-catenin and the downregulation of GSK-3β. The expression of SOX2, Nanog, and OCT4 were also higher in TSA-pretreated epithelial cells than in control cells. In the reproducible ischemic flap model, pretreatment with TSA enhanced resistance to hypoxia and increased the area of surviving tissue in transplanted flaps. The expression of Wnt signaling pathway components, stem-cell related biomarkers, and VEGF and CD34, which are involved in the regeneration of blood vessels, was also upregulated in TSA-pretreated flap tissue. CONCLUSIONS: TSA pretreatment protects free flaps against hypoxic injury and increases the area of surviving tissue by activating Wnt signaling and upregulating stem cell-related biomarkers

Lipidomic and transcriptomic profiles provide new insights into the triacylglycerol and glucose handling capacities of the Arctic fox

The Arctic fox (Vulpes lagopus) is a species indigenous to the Arctic and has developed unique lipid metabolism, but the mechanisms remain unclear. Here, the significantly increased body weight of Arctic foxes was consistent with the significantly increased serum very-low-density lipoprotein (VLDL), and the 40% crude fat diet further increased the Arctic fox body weight. The enhanced body weight gain stems primarily from increased subcutaneous adipose tissue accumulation. The adipose triacylglycerol and phosphatidylethanolamine were significantly greater in Arctic foxes. The adipose fatty-acid synthase content was significantly lower in Arctic foxes, highlighting the main role of exogenous fatty-acids in fat accumulation. Considering the same diet, liver-derived fat dominates adipose expansion in Arctic foxes. Liver transcriptome analysis revealed greater fat and VLDL synthesis in Arctic foxes, consistent with the greater VLDL. Glucose homeostasis wasn’t impacted in Arctic foxes. And the free fatty-acids in adipose, which promote insulin resistance, also did not differ between groups. However, the hepatic glycogen was greater in Arctic foxes and transcriptome analysis revealed upregulated glycogen synthesis, improving glucose homeostasis. These results suggest that the superior fat accumulation capacity and distinct characteristics of hepatic and adipose lipid and glucose metabolism facilitate glucose homeostasis and massive fat accumulation in Arctic foxes

Interleukin-41: a novel serum marker for the diagnosis of alpha-fetoprotein-negative hepatocellular carcinoma

BackgroundFor the lack of effective serum markers for hepatocellular carcinoma(HCC) diagnosis, it is difficult to detect liver cancer and identify its recurrence early.MethodsDatabases were used to analyze the genes potentially associated with alpha-fetoprotein(AFP). ELISA assay was used to detect the serum IL-41 in HCC, liver metastases, hepatitis, and healthy people. Immunohistochemical staining was used to analyze the relative quantification of IL-41 in HCC and paracancer tissues. Various survival curves were plotted according to clinical pathological data and helped us draw the ROC curve of IL-41 diagnosis of HCC.ResultsThe serum expression of IL-41 was highest in AFP negative HCC patients and significantly higher than that in AFP positive HCC and metastatic cancer patients. There was a significant negative correlation between elevated serum IL-41 and AFP(&lt;1500ng/ml). The clinicopathological features suggested that the serum IL-41 level was significantly correlated with capsule invasion, low differentiation and AFP. High serum expression of IL-41 suggests poorer survival and earlier recurrence after resection, and IL-41 upregulated in patients with early recurrence and death. The expression of IL-41 was higher in HCC tissues of patients with multiple tumors or microvascular invasion. The ROC curve showed that serum IL-41 had a sensitivity of 90.17 for HCC and a sensitivity of 96.63 for AFP-negative HCC, while the specificity was higher than 61%.ConclusionIL-41 in serum and tissue suggests poor prognosis and postoperative recurrence in HCC patients and could be a new serum diagnostic marker for AFP negative patients

Modeling and Verification of a New Hyperelastic Model for Rubber-Like Materials

The essential evaluation criterion for the hyperelastic model is its ability to describe the mechanical behavior of rubber-like materials under different deformation modes over a large deformation range accurately. Based on the Seth strain tensor invariant, a new hyperelastic model for isotropic and incompressible rubber-like materials is proposed. In order to investigate the prediction ability of the new model, the parameters of the new model, the Yeoh model, and the Carroll model are identified by test data of 8% vulcanized rubber and two different types of carbon black filled rubber, respectively. To this end, the data of uniaxial tension and equibiaxial tension are used simultaneously. Then, the same set of model parameters is used for prediction of pure shear (plane tension) deformation. The results show that the new model not only can predict the test data of pure shear (or plane tension) accurately, but also can be reliable to describe the response of various rubber materials over a large deformation range. Finally, the finite element simulation and experiment on static stiffness of rubber bushing are carried out based on the new model. By comparison of the experimental data with the simulation data, the new model can accurately reflect the mechanical behavior of rubber bushing. The new model can be used for performance analysis of rubber products and has better application value.</jats:p

Advancing wavefront sensing: meta Shack-Hartmann sensor enhances phase imaging

Abstract A meta-lens array-based Shack-Hartmann wavefront sensor has been developed to break the limits imposed by the size and curvature of traditional micro-lenses, which significantly improves both sampling density and angular resolution of phase measurement. Metasurface advances the field of optical phase measurement to smaller-scale complex wavefront characterization