Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients: Results from the GUARD-C Cohort

BACKGROUND: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. METHODS: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhotic genotype (G)1 patients assigned to peginterferon alfa-2a/ribavirin for 48 weeks. The probability of SVR24 was identified by a baseline scoring system (range: 0-9 points) on which scores of 5 to 9 and <5 represent high and low probability of SVR24, respectively. RESULTS: SVR24 rates were 46.1% (754/1634), 77.1% (279/362), 68.0% (514/756), and 51.3% (203/396), respectively, in G1, 2, 3, and 4 patients. Overall, 16.9% and 21.8% patients experienced 651 sr-RD for peginterferon alfa and ribavirin, respectively. Among Caucasian noncirrhotic G1 patients: female sex, lower body mass index, pre-existing cardiovascular/pulmonary disease, and low hematological indices were prognostic factors of sr-RD; SVR24 was lower in patients with 651 vs. no sr-RD by Week 4 (37.9% vs. 54.4%; P = 0.0046) and Week 12 (41.7% vs. 55.3%; P = 0.0016); sr-RD by Week 4/12 significantly reduced SVR24 in patients with scores <5 but not 655. CONCLUSIONS: In conclusion, sr-RD to peginterferon alfa-2a/ribavirin significantly impacts on SVR24 rates in treatment-naive G1 noncirrhotic Caucasian patients. Baseline characteristics can help select patients with a high probability of SVR24 and a low probability of sr-RD with peginterferon alfa-2a/ribavirin

Research laboratories: a change for experiment and confrontation

At the end of studies for the inter-university teaching degree in naval and nautical design, final year students, under the supervision of teaching staff, have a guided project experience that has the aim of consolidating and instilling the know-how acquired during the previous years\u2019 educational cours

Technology and neuroarchitecture

This paper is part of an ongoing research project involving the Department of Architecture and Design at the University of Genoa, as well as entities from both the professional training and industrial worlds. The primary objective of this research is the development of a tool that is useful both for designers and for users. Based on the concept of smart mock-ups, previously developed by the authors, the focus has been declined on the world of nautical design, with the aim of measuring, through qualitative parameters, the user experience in a built environment, whether it is a relaxing or working environment. The first and fundamental step involves defining the 'state of the user' through a vector of measurable variables using a network of sensors that do not significantly alter the UX with the surrounding space. This article presents the state of the art of techniques and sensors that can be used for research purposes, as well as the proposed experimental setting to verify the initial working hypotheses. Then we will describe how research will move on to obtain an affordable and efficient tool for nautical designers. Here, we will describe different types of methods that can be used in neuroscience, from standard ones (like emotions recognition software based on FACS, or biometric sensors like heart rate variability, galvanic skin response), to modern ones (like the use of electroencephalography, functional magnetic resonance imaging) and eye tracking

Quantifying human factor in ships operation via an AI based emotions recognition

Human factor evaluation via emotion recognition from face micro-expressions and speech analysis holds significant value in the field of shipping and logistics. Understanding the emotional state and engagement levels of individuals involved in shipping operations can greatly impact efficiency, customer satisfaction, and overall success in the industry. Emotions recognition from face micro-expressions plays a crucial role in assessing the well-being and mental state of shipping personnel. The ability to detect micro-expressions can help identify signs of stress, fatigue, frustration, or other emotional states that may affect their performance. By recognizing these emotions, shipping companies can take proactive measures to address issues, provide the necessary support, and ensure the well-being of their employees. This can lead to improved job satisfaction, reduced turnover rates, and increased productivity. Speech analysis also plays a significant role in human factor evaluation within the shipping industry. Effective communication is essential for successful shipping operations, and analyzing speech patterns can provide insights into the emotional state, engagement, and clarity of individuals involved. By analyzing the tone, pitch, and speed of speech, shipping companies can identify signs of confusion, frustration, or lack of engagement. This information can be used to optimize training programs, improve communication protocols, and enhance overall operational efficiency. Moreover, emotion recognition and speech analysis can be used in customer service within the shipping industry. Understanding the emotions and satisfaction levels of customers through their facial expressions and speech can enable shipping companies to tailor their services and address any concerns promptly. This personalized approach enhances customer experience, strengthens relationships, and ultimately leads to customer loyalty and repeat business. While utilizing emotion recognition and speech analysis in the shipping industry offers numerous benefits, ethical considerations must be taken into account. Ensuring the privacy and consent of individuals involved is of utmost importance. Companies must handle personal information responsibly and transparently, adhering to legal and ethical standards. Additionally, biases and discrimination risks associated with emotion recognition technology should be acknowledged and addressed to ensure fair and equitable use. In conclusion, human factor evaluation via emotion recognition from face micro-expressions and speech analysis holds substantial value in the shipping industry. By understanding and interpreting emotions, shipping companies can enhance employee well-being, improve communication, optimize operations, and provide exceptional customer service. However, ethical guidelines must be followed to protect privacy, avoid biases, and ensure the responsible use of these technologies in the shipping sector

La nautica seme della rinascita nella citt\ue0 resiliente. Genova ieri, oggi e domani.

Genova ha osservato il fenomeno resiliente di assorbimento del degrado legato soprattutto al vecchio porto commerciale. Con l'innesco di nuove attivit\ue0 turistiche si \ue8 osservato un concreto fenomeno di rinascita dell'economia lungo le banchine portuali. In occasione delle celebrazioni del 500\ub0 anno Colombiano il vecchio porto storico ha trovato la nuova configurazione della marina del Porto Antico. Mentre a ponente \ue8 sorto il Porto commerciale di Voltri-Pr\ue0 \ue8 sorto anche il Borgo Marina di Genova Aeroporto rivitalizzando l'intero quartiere di Sestri Ponente. Il terzo esempio di questo tipo \ue8 tuttora in f\ueceri e sar\ue0 tutto da dimostrare nei prossimi anni. Si tratta del quartiere della Fiera del Mare alla foce del Bisagno, interessato dalla proposta BLUE PRINT edita sulla base di una visione di Renzo Piano

MAREMAGAZINE, SUPERYACHTS E NAVI DA CROCIERA: LA RICERCA SULLO STATO DELL\u2019ARTE

CITAZIONE E RECENSIONE DEI VOLUMI "SUPERYACHTS YACHT DESIGN STUDIO WORKSHOP" E "CRUISE VESSELS DESIGN" IN: www.ilmaremagazine.com, mare magazine - blog della libreria internazionale del mare e plurisettimanale n\ub071-2011, Roma, pubblicato il 23 gennaio 2012. Recensione / Citazione inserita in tipologia di Prodotto Altro poich\ue8 non esiste Tipologia specifica. Recensione / Citazione a cura della redazione della rivista

RIFINITURE D'INTERNI, MAMOLI PER IL DESIGN

CITAZIONE E RECENSIONE DEI VOLUMI "SUPERYACHTS YACHT DESIGN STUDIO WORKSHOP" E "CRUISE VESSELS DESIGN" IN: Rifiniture d\u2019interni, n\ub02 Marzo - Aprile 2010, Edinterni, Milano,pp. 53

PATRIM, about a research experience

The paper presents a research experience, funded by Regione Liguria and developed since the beginning of the year 2021. The request was to get, among other materials and research outcomes, concepts for the park paths (for highlighting the access to the park from seven little different towns) conveying a sense of community and belonging for the locals together with a witness of the local traditions for visitors and travellers. The research group started to work on the paths, as it was pretty clear the request for prerequisite non-misleading, shared ‘signs’, presences of intangibles heritage and material culture, that could be read by visitors and felt as genuine by local inhabitants. The call was challenging, indeed, but through design-thinking, carefully detecting the semantics on the field along with sensing the narratives within the communities, an undeniable result could be performed. Kick-off was an exploration of case studies, even identifying what was unsaid within the request. Then, a series of field activities were handled, such as numerous site inspections and interviews. Through the narration of the research experience – in its methods and developments – along with the presentation of final outcome – in the form of the presented project – we aim to offer our personal viewpoint for the expression of material culture and local cultural heritage

MARINE DESIGN RESEARCH & EDUCATION

Universit\ue0 degli Studi di Genova \ue8 stata presente al 52\ub0 Salone Nautico Internazionale di Genova con una manifestazione dal titolo \u201cMARINE DESIGN RESEARCH & EDUCATION\u201d. Dal 6 al 14 ottobre, nel Padiglione B, \ue8 stato proposto il lavoro di ricerca effettuato negli ultimi anni dai gruppi afferenti ai Corsi di Laurea Magistrale in Design Navale Nautico e Ingegneria Nautica, attivit\ue0 fortemente improntata al fine di ottenere nuove visioni per un futuro sostenibile per la nautica da diporto. Dalle tesi di dottorato, alle pubblicazioni, passando per lo sviluppo di rapporti internazionali, ma senza mai dimenticare i lavori prodotti dagli studenti all\u2019interno dei laboratori di progettazione, il team di ricerca della Scuola Politecnica ha offerto una settimana intensa, ricca di eventi e momenti di incontro tra le diverse figure che gravitano attorno al mondo della ricerca applicata alla nautica o anche solo per chi \ue8 interessato a scoprire un nuovo approccio a questa dimensione disciplinare. In parallelo all'evento espositivo, infine, sono state organizzate conferenze e lezioni didattiche

CamBioVIA : storie di territori parchi

La ricerca Interreg-maritime cambiovia si occupa dei territori interni da riscoprire e valorizzare per ristabilire un nuovo equilibrio tra uomo e ambiente naturale. Sono Parchi riconosciuti dalla L.R. 12/95, intesi come aree sobrie e genuine. L’indagine si concentra sulle storie di allevatori che hanno deciso di investire in questi luoghi per praticare la transumanza e generare biodiversità producendo alimenti di alta qualità con un fortissimo legame territoriale. Le attività del progetto, attraverso la ricerca etnografica, ricostruiscono una narrazione per dar voce a un patrimonio di tradizioni isolate. Il passaggio da monadi a comunità custodi avviene mediante la co-progettazione del valore, attraverso artefatti materiali ed esperienze immateriali basate sulla progettazione di modelli integrati di economia montana e servizi ecosistemici. L’obiettivo è quello di promuovere consapevolezza, per favorire una sensibilità che riconosca questi giacimenti culturali e ambientali