Radiation Shielding Analysis and Optimisation for the MinPET Kimberlite Sorting Facility using the Monte Carlo Calculation Code, MCNPX

Abstract: Radiation shielding calculations, analysis and optimization process carried out in order to design shielding for a Mineral-Positron Emission Tomography (MinPET) facility are presented. PET is a nuclear imaging technique commonly used in diagnostic medicine. The technique is based on the detection of 511 keV coincident and co-linear photons produced from the annihilation of a positron (produced by a positron emitter) and a nearby electron. This technique is currently being developed for mineral detection and quantification, particularly diamonds in kimberlite rocks through the MinPET facility. The facility is aimed at improving diamond mining through the early detection of the diamond bearing rocks. High energy photons are produced via bremsstrahlung when a high energy, 40 MeV 5mA, electron beam impinges on a high density target - tungsten..

Helicopter Rotor Noise Prediction Using ONERA and DLR Euler/ Kirchhoff Methods

Euler/Kirchhoff methods have been developed at ONERA and DLR to predict the High Speed Impulsive (HSI) noise generated by helicopter rotors in hover or in forward flight. The main purpose of this common work is to validate the aeroacoustic computations with delocalized test cases. In hover, the aerodynamic and acoustic results obtained by each partner are in good agreement with experiment. In forward flight, a first set of computations is performed with three different sized "classical" grids. For both partners, the pressure coefficients on the blade are in better correlation with experiment when the grid is refined. However, the capture of the shock waves propagation beyond the blade is not accurate enough to perform satisfactory Kirchhoff computations. The minimum pressure peak and the recompression slope of the acoustic pressure signatures are not accurately predicted, whatever the grid refinement of the Kirchhoff surface locations may be. An

Helicopter rotor noise predictions using 3D computed aerodynamic data for different blade geometries

Communication to : Nineteenth European Rotorcraft Forum, Cernobbio, Como (Italy), September 14-16, 1993Available at INIST (FR), Document Supply Service, under shelf-number : 22419, issue : a.1993 n.167 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc

Prediction of HSI noise using a coupled Euler/Kirchhoff method for a helicopter in hoverflight

Communication to : 22nd European rotorcraft forum, Brighton (UK), september 17-19, 1996SIGLEAvailable at INIST (FR), Document Supply Service, under shelf-number : 22419, issue : a.1996 n.62 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Helicopter rotor noise prediction using ONERA and DLR Euler / Kirchhoff methods

Communication to : AHS technical specialist's meeting for rotorcraft acoustics and aerodynamics, Williamsburg (USA), October 28-30, 1997Available from INIST (FR), Document Supply Service, under shelf-number : 22419, issue : a.1997 n.192 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc

A comparative study of three methodologies for modeling dynamic stall

Communication to : 28th European rotorcraft forum, Bristol (Grande Bretagne), September 17-20, 2002SIGLEAvailable from INIST (FR), Document Supply Service, under shelf-number : 22419, issue : a.2002 n.184 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Methodes de calcul aerodynamique appliquees aux rotors d'helicopteres a l'ONERA

Communications to : 75th AGARD FDP on aerodynamics and aeroacoustics of rotorcraft, Berlin (Germany), october 10-13, 1994SIGLEAvailable at INIST (FR), Document Supply Service, under shelf-number : 22419, issue : a.1994 n.107 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Perspectives of patients and clinicians on older patient mobility on acute medical wards: a qualitative study

Abstract Background Low mobility during an acute care medical hospitalization is frequent and associated with adverse outcomes, particularly among older patients. Better understanding barriers and facilitators to improve mobility during hospitalization could help develop effective interventions. The goal of this study was to assess barriers and facilitators to older medical patients’ hospital mobility, from the point of view of patients and clinicians, to develop a framework applicable in clinical practice. Methods We conducted a qualitative study in one university and two non-university hospitals of two different language and cultural regions of Switzerland, including 13 focus groups (FGs; five with patients, eight with clinicians). We included 24 adults aged 60 years or older hospitalized on an acute general internal medicine ward of one of the three participating hospitals during the previous years, and 34 clinicians (15 physicians, nine nurses/nursing assistants, 10 physiotherapists) working on those wards. The FG guides included open-ended questions exploring mobility experiences, expectations, barriers and facilitators to mobility, consequences of low mobility and knowledge on mobility. We applied an inductive thematic analysis. Results We identified four themes of barriers and facilitators to mobility: 1) patient-related factors; 2) clinician-related factors; 3) social interactions; and 4) non-human factors. Clinician-related factors were only mentioned in clinician FGs. Otherwise, subthemes identified from patient and clinician FGs were similar and codes broadly overlapped. Subthemes included motivation, knowledge, expectations, mental and physical state (theme 1); process, knowledge – skills, mental state – motivation (theme 2); interpersonal relationships, support (theme 3); hospital setting – organization (theme 4). Conclusions From patients’ and clinicians’ perspectives, a broad spectrum of human and structural factors influences mobility of older patients hospitalized on an acute general internal medicine ward. New factors included privacy issues and role perception. Many of those factors are potentially actionable without additional staff resources. This study is a first step in participatory research to improve mobility of older medical inpatients

OCIAD1 is a host mitochondrial substrate of the hepatitis C virus NS3-4A protease.

The hepatitis C virus (HCV) nonstructural protein 3-4A (NS3-4A) protease is a key component of the viral replication complex and the target of protease inhibitors used in current clinical practice. By cleaving and thereby inactivating selected host factors it also plays a role in the persistence and pathogenesis of hepatitis C. Here, we describe ovarian cancer immunoreactive antigen domain containing protein 1 (OCIAD1) as a novel cellular substrate of the HCV NS3-4A protease. OCIAD1 was identified by quantitative proteomics involving stable isotopic labeling using amino acids in cell culture coupled with mass spectrometry. It is a poorly characterized membrane protein believed to be involved in cancer development. OCIAD1 is cleaved by the NS3-4A protease at Cys 38, close to a predicted transmembrane segment. Cleavage was observed in heterologous expression systems, the replicon and cell culture-derived HCV systems, as well as in liver biopsies from patients with chronic hepatitis C. NS3-4A proteases from diverse hepacivirus species efficiently cleaved OCIAD1. The subcellular localization of OCIAD1 on mitochondria was not altered by NS3-4A-mediated cleavage. Interestingly, OCIAD2, a homolog of OCIAD1 with a cysteine residue in a similar position and identical subcellular localization, was not cleaved by NS3-4A. Domain swapping experiments revealed that the sequence surrounding the cleavage site as well as the predicted transmembrane segment contribute to substrate selectivity. Overexpression as well as knock down and rescue experiments did not affect the HCV life cycle in vitro, raising the possibility that OCIAD1 may be involved in the pathogenesis of hepatitis C in vivo

Predictions of high-speed impulsive rotor noise using Euler/Kirchhoff methods of Onera and NAL

Communication to : HELI JAPAN 98, Gifu (Japan), April 21-23, 1998Available from INIST (FR), Document Supply Service, under shelf-number : 22419, issue : a.1998 n.46 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc