HybridNet: Dual-Branch Fusion of Geometrical and Topological Views for VLSI Congestion Prediction

Accurate early congestion prediction can prevent unpleasant surprises at the routing stage, playing a crucial character in assisting designers to iterate faster in VLSI design cycles. In this paper, we introduce a novel strategy to fully incorporate topological and geometrical features of circuits by making several key designs in our network architecture. To be more specific, we construct two individual graphs (geometry-graph, topology-graph) with distinct edge construction schemes according to their unique properties. We then propose a dual-branch network with different encoder layers in each pathway and aggregate representations with a sophisticated fusion strategy. Our network, named HybridNet, not only provides a simple yet effective way to capture the geometric interactions of cells, but also preserves the original topological relationships in the netlist. Experimental results on the ISPD2015 benchmarks show that we achieve an improvement of 10.9% compared to previous methods

A Review of Magnetic Nanoparticle-Based Surface-Enhanced Raman Scattering Substrates for Bioanalysis: Morphology, Function and Detection Application

Surface-enhanced Raman scattering (SERS) is a kind of popular non-destructive and water-free interference analytical technology with fast response, excellent sensitivity and specificity to trace biotargets in biological samples. Recently, many researches have focused on the preparation of various magnetic nanoparticle-based SERS substrates for developing efficient bioanalytical methods, which greatly improved the selectivity and accuracy of the proposed SERS bioassays. There has been a rapid increase in the number of reports about magnetic SERS substrates in the past decade, and the number of related papers and citations have exceeded 500 and 2000, respectively. Moreover, most of the papers published since 2009 have been dedicated to analytical applications. In the paper, the recent advances in magnetic nanoparticle-based SERS substrates for bioanalysis were reviewed in detail based on their various morphologies, such as magnetic core–shell nanoparticles, magnetic core–satellite nanoparticles and non-spherical magnetic nanoparticles and their different functions, such as separation and enrichment, recognition and SERS tags. Moreover, the typical application progress on magnetic nanoparticle-based SERS substrates for bioanalysis of amino acids and protein, DNA and RNA sequences, cancer cells and related tumor biomarkers, etc., was summarized and introduced. Finally, the future trends and prospective for SERS bioanalysis by magnetic nanoparticle-based substrates were proposed based on the systematical study of typical and latest references. It is expected that this review would provide useful information and clues for the researchers with interest in SERS bioanalysis

Role of air-sea heat flux on the transformation of Atlantic Water encircling the Nordic Seas

This study reveals that air-sea heat exchange plays differing roles in the transformation of Atlantic Water along the two northward-flowing warm currents in the Nordic Seas, which needs to be considered to understand high-latitude response to climate change

Determinants of low birth weight among newborns delivered in China: a prospective nested case-control study in a mother and infant cohort

This nested case-control study aimed to investigate the determinants of low birth weight among newborn babies delivered in Shenzhen, Guangdong, China. We recorded socio-demographic data, health status before pregnancy, pregnancy outcomes and complications in a Shenzhen mother and infant cohort. Among 8951 cases, 401 (4.48%) had low birth weight and 1.65% were full-term with LBW. Maternal body mass index, family income, history of pregnancy, hypertension before pregnancy, vaginal bleeding in 1st trimester, pregnancy-related diabetes, hypertension, placenta previa, placental abruption, premature rupture of membrane, oligohydramnios, and placental types were significantly associated with low birth weight (P < 0.05). In this study, high-risk and mainly preventable factors were linked to low birth weight. Adequate antenatal care, proper maternal nutrition and implementation of proven strategies to prevent high-risk factors may be effective ways to reduce the incidence of low birth weight