Weak Hopf Algebras, Smash Products and Applications to Adjoint-Stable Algebras

For a semisimple quasi-triangular Hopf algebra $\left( H,R\right)$ over a field $k$ of characteristic zero, and a strongly separable quantum commutative $H$-module algebra $A$ over which the Drinfeld element of $H$ acts trivially, we show that $A\#H$ is a weak Hopf algebra, and it can be embedded into a weak Hopf algebra $\operatorname{End}A^{\ast}\otimes H$. With these structure, $_{A\#H}\operatorname{Mod}$ is the monoidal category introduced by Cohen and Westreich, and $_{\operatorname{End}A^{\ast}\otimes H}\mathcal{M}$ is tensor equivalent to $_{H}\mathcal{M}$. If $A$ is in the M{\"{u}}ger center of $_{H}{\mathcal{M}}$, then the embedding is a quasi-triangular weak Hopf algebra morphism. This explains the presence of a subgroup inclusion in the characterization of irreducible Yetter-Drinfeld modules for a finite group algebra

Prognostic value of routine laboratory variables in prediction of breast cancer recurrence.

The prognostic value of routine laboratory variables in breast cancer has been largely overlooked. Based on laboratory tests commonly performed in clinical practice, we aimed to develop a new model to predict disease free survival (DFS) after surgical removal of primary breast cancer. In a cohort of 1,596 breast cancer patients, we analyzed the associations of 33 laboratory variables with patient DFS. Based on 3 significant laboratory variables (hemoglobin, alkaline phosphatase, and international normalized ratio), together with important demographic and clinical variables, we developed a prognostic model, achieving the area under the curve of 0.79. We categorized patients into 3 risk groups according to the prognostic index developed from the final model. Compared with the patients in the low-risk group, those in the medium- and high-risk group had a significantly increased risk of recurrence with a hazard ratio (HR) of 1.75 (95% confidence interval [CI] 1.30-2.38) and 4.66 (95% CI 3.54-6.14), respectively. The results from the training set were validated in the testing set. Overall, our prognostic model incorporating readily available routine laboratory tests is powerful in identifying breast cancer patients who are at high risk of recurrence. Further study is warranted to validate its clinical application

MC-MLP:Multiple Coordinate Frames in all-MLP Architecture for Vision

In deep learning, Multi-Layer Perceptrons (MLPs) have once again garnered attention from researchers. This paper introduces MC-MLP, a general MLP-like backbone for computer vision that is composed of a series of fully-connected (FC) layers. In MC-MLP, we propose that the same semantic information has varying levels of difficulty in learning, depending on the coordinate frame of features. To address this, we perform an orthogonal transform on the feature information, equivalent to changing the coordinate frame of features. Through this design, MC-MLP is equipped with multi-coordinate frame receptive fields and the ability to learn information across different coordinate frames. Experiments demonstrate that MC-MLP outperforms most MLPs in image classification tasks, achieving better performance at the same parameter level. The code will be available at: https://github.com/ZZM11/MC-MLP

STUDY ON REINFORCEMENT OF FABRICATED HOLLOW SLAB BRIDGE BY POLYURETHANE-CEMENT COMPOSITE (PUC)

In this paper, a new polyurethane-cement composite (PUC) material is used to reinforce a 25-year hollow slab bridge. PUC material is composed of polyurethane and cement, which has good mechanical properties. After pouring PUC material at the bottom of the hollow slabs, the traffic can be restored in a short time. Ultimate bearing capacity was discussed based on the concrete structures. The failure mode of the reinforced beam depends on the PUC material. The strengthening process includes surface treatment of concrete, formwork erection and polyurethane cement pouring. In order to verify the effectiveness of PUC reinforced bridges, load tests were carried out before and after reinforcement. The test results showed that PUC could remove the bridge load and increase the stiffness of the hollow slabs

Robust Detection of Moving Human Target Behind Wall via Impulse through-Wall Radar

Through-wall human target detection is highly desired in military applications. We have developed an impulse through-wall radar (TWR) to address this problem. In order to obtain a robust detection performance, firstly we adopt the exponential average background subtraction (EABS) method to mitigate clutters and improve the signal-to-clutter ratio (SCR). Then, different from the conventional constant false alarm rate (CFAR) methods that are applied along the fast-time dimension, we propose a new CFAR method along the slow-time dimension to resist the residual clutters in the clutter mitigation output because of timing jitters, based on the presence of a larger relative variation of human target moving in and out in comparison with that of residual clutters in the slow-time dimension. The proposed method effectively solves the false alarm issue caused by residual clutters in the conventional CFAR methods, and obtains robust detection performance. Finally, different through-wall experiments are provided to verify the proposed method.Defence Science Journal, 2013, 63(6), pp.636-642, DOI:http://dx.doi.org/10.14429/dsj.63.576

MicroRNA Regulation and Tissue-Specific Protein Interaction Network

BACKGROUND: 'Fine-tuning' of protein abundance makes microRNAs (miRNAs) pervasively implicated in human biology. Although targeting many mRNAs endows the power of single miRNA to regulate complex biological processes, its functional roles in a particular tissue will be inevitably restricted because only a subset of its target genes is expressed. METHODS: Here, we analyze the characteristics of miRNA regulation upon target genes according to tissue-specific gene expression by constructing tissue-specific protein interaction networks for ten main types of tissues in the human body. RESULTS: Commonly expressed proteins are under more intensive but lower-cost miRNAs control than proteins with the tissue-specific expression. MiRNAs that target more commonly expressed genes usually regulate more tissue-specific genes. This is consistent with the previous finding that tissue-specific proteins tend to be functionally connected with commonly expressed proteins. But to a particular miRNA such a balance is not invariable among different tissues implying diverse tissue regulation modes executed by miRNAs. CONCLUSION: These results suggest miRNAs that interact with more commonly expressed genes can be expected to play important tissue-specific roles

Layered Functional Network Analysis of Gene Expression in Human Heart Failure

BACKGROUND: Although dilated cardiomyopathy (DCM) is a leading cause of heart failure (HF), the mechanism underlying DCM is not well understood. Previously, it has been demonstrated that an integrative analysis of gene expression and protein-protein interaction (PPI) networks can provide insights into the molecular mechanisms of various diseases. In this study we develop a systems approach by linking public available gene expression data on ischemic dilated cardiomyopathy (ICM), a main pathological form of DCM, with data from a layered PPI network. We propose that the use of a layered PPI network, as opposed to a traditional PPI network, provides unique insights into the mechanism of DCM. METHODS: Four Cytoscape plugins including BionetBuilder, NetworkAnalyzer, Cerebral and GenePro were used to establish the layered PPI network, which was based upon validated subcellular protein localization data retrieved from the HRPD and Entrez Gene databases. The DAVID function annotation clustering tool was used for gene ontology (GO) analysis. RESULTS: The assembled layered PPI network was divided into four layers: extracellular, plasma membrane, cytoplasm and nucleus. The characteristics of the gene expression pattern of the four layers were compared. In the extracellular and plasma membrane layers, there were more proteins encoded by down-regulated genes than by up-regulated genes, but in the other two layers, the opposite trend was found. GO analysis established that proteins encoded by up-regulated genes, reflecting significantly over-represented biological processes, were mainly located in the nucleus and cytoplasm layers, while proteins encoded by down-regulated genes were mainly located in the extracellular and plasma membrane layers. The PPI network analysis revealed that the Janus family tyrosine kinase-signal transducer and activator of transcription (Jak-STAT) signaling pathway might play an important role in the development of ICM and could be exploited as a therapeutic target of ICM. In addition, glycogen synthase kinase 3 beta (GSK3B) may also be a potential candidate target, but more evidence is required. CONCLUSION: This study illustrated that by incorporating subcellular localization information into a PPI network based analysis, one can derive greater insights into the mechanisms underlying ICM