Recollements induced by left Frobenius pairs

Let $T$ be a right exact functor from an abelian category $\mathscr{B}$ into another abelian category $\mathscr{A}$. Then there exists an abelian category, named comma category and denoted by $(T\downarrow\mathscr{A})$.In this paper, we construct left Frobenius pairs (resp. strong left Frobenius pairs) over $(T\downarrow\mathscr{A})$ using left Frobenius pairs (resp. strong left Frobenius pairs) over $\mathscr{A}$ and $\mathscr{B}.$ As a consequence, we obtain a recollement of (right) triangulated categories, generalizing the result of Xiong-Zhang-Zhang (J. Algebra 503 (2018) 21-55) about the recollement of additive (resp. triangulated) categories constructed from a triangular matrix algebra. This result is applied to the classes of flat modules and Gorenstein flat modules, the classes of Gorenstein projective modules and Gorenstein projective complexes, the class of Ding projective modules and the class of Gorenstein flat-cotorsion modules.Comment: 24 pages, all comments are welcom

RS-SVM Machine Learning Approach Driven by Case Data for Selecting Urban Drainage Network Restoration Scheme

ABSTRACTUrban drainage pipe network is the backbone of urban drainage, flood control and water pollution prevention, and is also an essential symbol to measure the level of urban modernization. A large number of underground drainage pipe networks in aged urban areas have been laid for a long time and have reached or practically reached the service age. The repair of drainage pipe networks has attracted extensive attention from all walks of life. Since the Ministry of ecological environment and the national development and Reform Commission jointly issued the action plan for the Yangtze River Protection and restoration in 2019, various provinces in the Yangtze River Basin, such as Anhui, Jiangxi and Hunan, have extensively carried out PPP projects for urban pipeline restoration, in order to improve the quality and efficiency of sewage treatment. Based on the management practice of urban pipe network restoration project in Wuhu City, Anhui Province, this paper analyzes the problems of lengthy construction period and repeated operation caused by the mismatch between the design schedule of the restoration scheme and the construction schedule of the pipe network restoration in the existing project management mode, and proposes a model of urban drainage pipe network restoration scheme selection based on the improved support vector machine. The validity and feasibility of the model are analyzed and verified by collecting the data in the project practice. The research results show that the model has a favorable effect on the selection of urban drainage pipeline restoration schemes, and its accuracy can reach 90%. The research results can provide method guidance and technical support for the rapid decision-making of urban drainage pipeline restoration projects

Inducing Effect of Dihydroartemisinic Acid in the Biosynthesis of Artemisinins with Cultured Cells of Artemisia annua

Artemisinin has been used in the production of “artemisinin combination therapies” for the treatment of malaria. Feeding of precursors has been proven to be one of the most effective methods to enhance artemisinin production in plant cultured cells. At the current paper, the biosynthesis of artemisinin (ART) and its four analogs from dihydroartemisinic acid (DHAA) in suspension-cultured cells of Artemisia annua were investigated. ARTs were detected by HPLC/GC-MS and isolated by various chromatography methods. The structures of four DHAA metabolites, namely, dihydro-epi-deoxyarteannuin B, arteannuin I, arteannuin K, and 3-β-hydroxy-dihydro-epi-deoxyarteannuin B, were elucidated by physicochemical and spectroscopic analyses. The correlation between gene expression and ART content was investigated. The results of RT-PCR showed that DHAA could up-regulate expression of amorpha-4,11-diene synthase gene (ADS), amorpha-4,11-diene C-12 oxidase gene (CYP71AV1), and farnesyl diphosphate synthase gene (FPS) (3.19-, 7.21-, and 2.04-fold higher than those of control group, resp.), which indicated that biosynthesis processes from DHAA to ART were enzyme-mediated

Recollements induced by good (co)silting dg-modules

summary:Let $U$ be a dg-$A$-module, $B$ the endomorphism dg-algebra of $U$. We know that if $U$ is a good silting object, then there exist a dg-algebra $C$ and a recollement among the derived categories ${\mathbf D}(C,d)$ of $C$, ${\mathbf D}(B,d)$ of $B$ and ${\mathbf D}(A,d)$ of $A$. We investigate the condition under which the induced dg-algebra $C$ is weak nonpositive. In order to deal with both silting and cosilting dg-modules consistently, the notion of weak silting dg-modules is introduced. Thus, similar results for good cosilting dg-modules are obtained. Finally, some applications are given related to good 2-term silting complexes, good tilting complexes and modules.\looseness -

The Inhibitory Effect of a Novel Polypeptide Fraction from Arca subcrenata on Cancer-Related Inflammation in Human Cervical Cancer HeLa Cells

Inflammation is known to be closely associated with the development of cancer. The study was launched in human cervical cancer HeLa cells to investigate the antitumor and anti-inflammatory effects of P2, a marine polypeptide fraction from an important fishery resource Arca subcrenata. The basic research showed that P2 could suppress the production of nitric oxide in LPS-induced RAW264.7 macrophage cells as well as the secretion of inflammatory cytokines IL-6 and TNF-α in human cervical cancer HeLa cells. For the molecular mechanisms, P2 was shown to downregulate the gene expression of proinflammatory cytokines IL-6 and IL-8 and to inhibit the COX-2 and iNOS-related pathways in HeLa cells. In consequence, P2 might inhibit tumor development by blocking the interaction between tumor microenvironment and proinflammatory mediators. All findings indicate that P2 possesses the potential to be developed as a novel agent for cancer therapy

Four New Compounds Obtained from Cultured Cells of Artemisia annua

Four new compounds obtained from cultured cells of Artemisia annua were reported. Products were detected by HPLC-ELSD/GC-MS and isolated by chromatographic methods. The structures of four new compounds, namely 6-hydroxy arteannuin I (1), 1-hydroxy arteannuin I (2), 2-hydroxy arteannuin J (3), and 14-hydroxy arteannuin J (4), were elucidated using their physico-chemical properties by NMR and MS data analyses. The results from the spontaneous oxidative experiment indicated that the biosynthesis of the new compounds was enzyme-catalyzed. Interestingly, the enzymes in the cultured cells of A. annua showed the abilities of substrate-selective and region-selective hydroxylation of the sesquiterpene lactone. Furthermore, the artemisinin contents were increased by 50% and 80% compared to the control group after the addition of arteannuin I/J to the suspension-cultured cells of A. annua under light and dark culture conditions, respectively

A New in Vitro Anti-Tumor Polypeptide Isolated from Arca inflata

A new in vitro anti-tumor polypeptide, coded as J2-C3, was isolated from Arca inflata Reeve and purified by diethyl-aminoethanol (DEAE)-sepharose Fast Flow anion exchange and phenyl sepharose CL-4B hydrophobic chromatography. J2-C3 was identified to be a homogeneous compound by native polyacrylamide gel electrophoresis (Native-PAGE). The purity of J2-C3 was over 99% in reversed phase-high performance liquid chromatography (RP-HPLC). The molecular weight was determined as 20,538.0 Da by electrospray-ionization mass spectrometry (ESI-MS/MS). J2-C3 was rich in Glx (Gln + Glu), Lys, and Asx (Asp + Asn) according to amino acid analysis. Four partial amino acid sequences of this peptide were determined as L/ISMEDVEESR, KNGMHSI/LDVNHDGR, AMKI/LI/LNPKKGI/LVPR and AMGAHKPPKGNEL/IGHR via MALDI-TOF/TOF-MS and de novo sequencing. Secondary structural analysis by CD spectroscopy revealed that J2-C3 had the α-helix (45.2%), β-sheet (2.9%), β-turn (26.0%) and random coil (25.9%). The anti-tumor effect of J2-C3 against human tumor cells was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and the IC50 values of J2-C3 were 65.57, 93.33 and 122.95 µg/mL against A549, HT-29 and HepG2 cell lines, respectively. Therefore, J2-C3 might be developed as a potential anti-tumor agent