Super resolution dual-layer CBCT imaging with model-guided deep learning

Objective: This study aims at investigating a novel super resolution CBCT imaging technique with the dual-layer flat panel detector (DL-FPD). Approach: In DL-FPD based CBCT imaging, the low-energy and high-energy projections acquired from the top and bottom detector layers contain intrinsically mismatched spatial information, from which super resolution CBCT images can be generated. To explain, a simple mathematical model is established according to the signal formation procedure in DL-FPD. Next, a dedicated recurrent neural network (RNN), named as suRi-Net, is designed by referring to the above imaging model to retrieve the high resolution dual-energy information. Different phantom experiments are conducted to validate the performance of this newly developed super resolution CBCT imaging method. Main Results: Results show that the proposed suRi-Net can retrieve high spatial resolution information accurately from the low-energy and high-energy projections having lower spatial resolution. Quantitatively, the spatial resolution of the reconstructed CBCT images of the top and bottom detector layers is increased by about 45% and 54%, respectively. Significance: In future, suRi-Net provides a new approach to achieve high spatial resolution dual-energy imaging in DL-FPD based CBCT systems

Dynamic X-ray imaging with screen-printed perovskite CMOS array

Abstract High performance X-ray detector with ultra-high spatial and temporal resolution are crucial for biomedical imaging. This study reports a dynamic direct-conversion CMOS X-ray detector assembled with screen-printed CsPbBr3, whose mobility-lifetime product is 5.2 × 10−4 cm2 V–1 and X-ray sensitivity is 1.6 × 104 µC Gyair –1 cm–2. Samples larger than 5 cm $$\times$$ × 10 cm can be rapidly imaged by scanning this detector at a speed of 300 frames per second along the vertical and horizontal directions. In comparison to traditional indirect-conversion CMOS X-ray detector, this perovskite CMOS detector offers high spatial resolution (5.0 lp mm−1) X-ray radiographic imaging capability at low radiation dose (260 nGy). Moreover, 3D tomographic images of a biological specimen are also successfully reconstructed. These results highlight the perovskite CMOS detector’s potential in high-resolution, large-area, low-dose dynamic biomedical X-ray and CT imaging, as well as in non-destructive X-ray testing and security scanning