Sequential monitoring of response-adaptive randomized clinical trials

Clinical trials are complex and usually involve multiple objectives such as controlling type I error rate, increasing power to detect treatment difference, assigning more patients to better treatment, and more. In literature, both response-adaptive randomization (RAR) procedures (by changing randomization procedure sequentially) and sequential monitoring (by changing analysis procedure sequentially) have been proposed to achieve these objectives to some degree. In this paper, we propose to sequentially monitor response-adaptive randomized clinical trial and study it's properties. We prove that the sequential test statistics of the new procedure converge to a Brownian motion in distribution. Further, we show that the sequential test statistics asymptotically satisfy the canonical joint distribution defined in Jennison and Turnbull (\citeyearJT00). Therefore, type I error and other objectives can be achieved theoretically by selecting appropriate boundaries. These results open a door to sequentially monitor response-adaptive randomized clinical trials in practice. We can also observe from the simulation studies that, the proposed procedure brings together the advantages of both techniques, in dealing with power, total sample size and total failure numbers, while keeps the type I error. In addition, we illustrate the characteristics of the proposed procedure by redesigning a well-known clinical trial of maternal-infant HIV transmission.Comment: Published in at http://dx.doi.org/10.1214/10-AOS796 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org

LCSTS: A Large Scale Chinese Short Text Summarization Dataset

Automatic text summarization is widely regarded as the highly difficult problem, partially because of the lack of large text summarization data set. Due to the great challenge of constructing the large scale summaries for full text, in this paper, we introduce a large corpus of Chinese short text summarization dataset constructed from the Chinese microblogging website Sina Weibo, which is released to the public {http://icrc.hitsz.edu.cn/Article/show/139.html}. This corpus consists of over 2 million real Chinese short texts with short summaries given by the author of each text. We also manually tagged the relevance of 10,666 short summaries with their corresponding short texts. Based on the corpus, we introduce recurrent neural network for the summary generation and achieve promising results, which not only shows the usefulness of the proposed corpus for short text summarization research, but also provides a baseline for further research on this topic.Comment: Recently, we received feedbacks from Yuya Taguchi from NAIST in Japan and Qian Chen from USTC of China, that the results in the EMNLP2015 version seem to be underrated. So we carefully checked our results and find out that we made a mistake while using the standard ROUGE. Then we re-evaluate all methods in the paper and get corrected results listed in Table 2 of this versio