LWFA as a Preinjector for XFEL Driver Linac

In this paper, we propose to use the LWFA as the preinjector for XFEL driver linac. We can use LWFA to produce the femtosecond electron beam. The peak current of the produced beam can reach tens of $kA$ and is high enough to drive XFEL so that the present bunch compressing technique can be deserted. The output optical pusle length can be as short as $1 fs$

Amyloid Beta and Tau Proteins as Therapeutic Targets for Alzheimer's Disease Treatment: Rethinking the Current Strategy

Alzheimer's disease (AD) is defined by the concurrence of accumulation of abnormal aggregates composed of two proteins: Amyloid beta (Aβ) and tau, and of cellular changes including neurite degeneration and loss of neurons and cognitive functions. Based on their strong association with disease, genetically and pathologically, it is not surprising that there has been a focus towards developing therapies against the aggregated structures. Unfortunately, current therapies have but mild benefit. With this in mind we will focus on the relationship of synaptic plasticity with Aβ and tau protein and their role as potential targets for the development of therapeutic drugs. Finally, we will provide perspectives in developing a multifactorial strategy for AD treatment