Guanidinium l-glutamate

In the title compound, CH6N3 +·C5H8NO4 −, there are two independent cations and two independent anions in the asymmetric unit. In the crystal structure, cations and anions are linked by inter­molecular N—H⋯O hydrogen bonds into a three-dimensional network

Semantic Role Labeling as Dependency Parsing: Exploring Latent Tree Structures Inside Arguments

Semantic role labeling (SRL) is a fundamental yet challenging task in the NLP community. Recent works of SRL mainly fall into two lines: 1) BIO-based; 2) span-based. Despite ubiquity, they share some intrinsic drawbacks of not considering internal argument structures, potentially hindering the model's expressiveness. The key challenge is arguments are flat structures, and there are no determined subtree realizations for words inside arguments. To remedy this, in this paper, we propose to regard flat argument spans as latent subtrees, accordingly reducing SRL to a tree parsing task. In particular, we equip our formulation with a novel span-constrained TreeCRF to make tree structures span-aware and further extend it to the second-order case. We conduct extensive experiments on CoNLL05 and CoNLL12 benchmarks. Results reveal that our methods perform favorably better than all previous syntax-agnostic works, achieving new state-of-the-art under both end-to-end and w/ gold predicates settings.Comment: COLING 202

SAA1 identified as a potential prediction biomarker for metastasis of hepatocellular carcinoma via multi-omics approaches

BackgroundMetastasis is the major cause of high recurrence and mortality of hepatocellular carcinoma (HCC). Unfortunately, there are few reports on effective biomarkers of HCC metastasis. Previous studies have reported that SAA1 may be a predictor and prognostic biomarker for multiple malignant tumors. However, the role of SAA1 in HCC has not yet been investigated.MethodsWe applied RNA sequencing and proteomics analysis to investigate the expression landscape of HCC cell lines and patient serum, respectively. SAA1 is a common key gene and listed as a candidate biomarker of HCC metastasis. It was validated in two cell lines, 107 participants serum, and 63 matched HCC and adjacent non-tumorous liver tissues. Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx), and The Cancer Genome Atlas (TCGA) datasets were integrated to explore SAA1 expression among various cell types and organs. The diagnostic and prognostic value of SAA1 in HCC were determined through receiver operating characteristic (ROC) and Kaplan–Meier curves. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and protein-protein interaction (PPI) network were constructed for SAA1, as well as for its co−expressed genes. We further analyzed the correlation between SAA1 and co-expression genes.ResultsWe found 7 differentially expressed genes (DEGs) and 14 differentially expressed proteins (DEPs) were related to HCC metastasis. SAA1, a key candidate biomarker, was highly enriched in hepatocytes and liver organ, and it was also highly expressed in HCC cells and the serum and tissues of HCC patients. The results of ROC curve analysis indicated that SAA1 had better predictive values for distinguishing HCC metastasis from non-metastasis. Kaplan-Meier curve analysis revealed that HCC patients with higher SAA1 expression had worse overall survival.ConclusionsOur findings provide new insights into HCC metastasis by identifying candidate gene prediction biomarkers for HCC metastasis

Effect of electrolytes on electrochemical properties of MmNi(5)-based hydrogen storage alloy

This Project is financially supported by the National Natural Foundations of China (51261003), the Natural Foundations of Guangxi Province (2012GXNSFGA060002; 2011GXNSFD018004; 201201ZD009) Guangxi Experiment center of information science (20130113) and National students’ Innovative Project (101059530) and National students’ Innovative Project (101059530).The effect of electrolytes on the electrochemical properties of MmNi(3.68)Co(0.72)Mn(0.43)Al(0.17) hydrogen storage alloy electrodes has been investigated at 303 K and 273 K. Three electrolytes (EL1, EL2, EL3) were obtained by adding 2 wt%, 4 wt% and 6 wt% LiOH into the original electrolyte EO (6 M/ L KOH), respectively. The results indicate that the addition of LiOH improves the discharge capacity and cycle life at 303 K and 273 K. The highest maximum capacity and capacity retention (after 50th cycles) have been observed in electrolyte EL2. However, the high-rate dischargeability (HRD) decreases gradually from EO to EL3 at the two temperatures because of the addition of LiOH. The corrosion current I-corr from Tafel Polarization curves (TP) and the resistance of the oxide layer R-ol from electrochemical impedance spectroscopy (EIS) indicates that the alloy electrode worked in EL1 has a better anti-corrosion ability. The real surface area of the electrodes estimated with EIS analysis, decrease from 51.95 cm(2) in EO to 15.6 cm(2) in EL2, but increase to 31.59 cm(2) in EL3 after being fully activated. The additional LiOH improves the anti-pulverization ability of alloy powders, delay the loss of active elements within the alloy electrode, resulting in an inproved capacity retention of alloy electrode. Meanwhile, the electrochemical kinetics analysis suggests that the charge-transfer reaction at the interface of electrode surface and electrolyte is the rate-determining step when tested at 303 K and 273 K.Publisher PDFPeer reviewe

Association between dietary folate intake and the risk of osteoporosis in adults: a cross-sectional study

Abstract Background Increased intake of specific vitamins has been linked to a decreased prevalence of osteoporosis. However, the association between dietary folate intake and the risk of osteoporosis in the general population remains incompletely understood. Therefore, we aimed to determine the association between dietary folate intake and the risk of osteoporosis in the general population of the USA. Methods In this cross-sectional study, data from the National Health and Nutrition Examination Survey (2017–2020) were collected. Osteoporosis was considered to be indicated by a bone mineral density greater than 2.5 standard deviations below the mean of the young adult reference group. Dietary folate intake was measured by a 24-hour dietary recall. Multivariate logistic regression models and restricted cubic spline models were used. Results The study included 2297 participants (mean age: 63.69 ± 0.35 years), 49.92% of whom were female. In the general population, increased dietary folate intake was directly associated with a decreased risk of osteoporosis (P for trend = 0.005). In the age > 60 years and female subgroups, folate intake was inversely associated with the risk of osteoporosis (P for trend < 0.001). The dose‒response curve suggested that this association was nonlinear (P for nonlinearity = 0.015). Conclusions Our cross-sectional study provides initial insights into the inverse association between dietary folate intake and the risk of osteoporosis in the general U.S. population. Further research is needed to confirm these associations

Thermal Catalytic Decomposition of Dimethyl Methyl Phosphonate Using CuO-CeO2/&gamma;-Al2O3

Chemical warfare agents (CWAs) are highly toxic and fast-acting and are easy to cause large-scale poisoning to humans and livestock after being released. The activated carbon used for CWAs adsorption has disadvantages of limited adsorption capacity, easy aging and deactivation. Metal oxides have environmental stability, and they are characterized by long lasting and broad spectrum when used for thermal catalytic decomposition. Therefore, in this study, the supported copper&ndash;cerium catalyst CuO-CeO2/&gamma;-Al2O3 was prepared using an equal volume impregnation method. The thermal catalytic decomposition performance was studied using sarin CWAs simulant dimethyl methyl phosphonate (DMMP) as the target compound. The results show that the CuO-CeO2/&gamma;-Al2O3 catalyst with a CeO2 loading of 5% exhibited better thermal catalytic decomposition performance of DMMP. The catalyst provided protection against DMMP for 237 min at 350 &deg;C; CuO was highly dispersed on CuO-5% CeO2/&gamma;-Al2O3, and there was a strong interaction between Cu and Ce on CuO-5% CeO2/&gamma;-Al2O3, which promoted the generation of surface-adsorbed oxygen, leading to a better thermal catalytic decomposition performance of DMMP. This study is expected to provide a reference for the study of catalysts for the thermal catalytic decomposition of CWAs

Thermal Catalytic Decomposition of Dimethyl Methyl Phosphonate Using CuO-CeO₂/<i>γ</i>-Al₂O₃

Chemical warfare agents (CWAs) are highly toxic and fast-acting and are easy to cause large-scale poisoning to humans and livestock after being released. The activated carbon used for CWAs adsorption has disadvantages of limited adsorption capacity, easy aging and deactivation. Metal oxides have environmental stability, and they are characterized by long lasting and broad spectrum when used for thermal catalytic decomposition. Therefore, in this study, the supported copper–cerium catalyst CuO-CeO2/γ-Al2O3 was prepared using an equal volume impregnation method. The thermal catalytic decomposition performance was studied using sarin CWAs simulant dimethyl methyl phosphonate (DMMP) as the target compound. The results show that the CuO-CeO2/γ-Al2O3 catalyst with a CeO2 loading of 5% exhibited better thermal catalytic decomposition performance of DMMP. The catalyst provided protection against DMMP for 237 min at 350 °C; CuO was highly dispersed on CuO-5% CeO2/γ-Al2O3, and there was a strong interaction between Cu and Ce on CuO-5% CeO2/γ-Al2O3, which promoted the generation of surface-adsorbed oxygen, leading to a better thermal catalytic decomposition performance of DMMP. This study is expected to provide a reference for the study of catalysts for the thermal catalytic decomposition of CWAs