Dynamic response and dangerous point stress analysis of gear transmission system

Gear transmission is the principal power transmission mode of many machine, the reliability of transmission system has important influence on the accomplishment of daily task. This paper made a gear transmission system as the research object, we build the two-stage gear transmission system model and calculate its dynamic response in theory. Then, we study the mesh stiffness of gear concerning the variation of the mesh position from the gear transmission system. On the basis of these work, we establish the gear system’s finite element simulation model considering the tooth contact of internal gear system. After the simulation, we had get the contact response and the time history of some important area’s equivalent stress. Through these work, we can study the contact stress of the two-stage gear system in theory method and finite element simulation method, which has a guiding significance on the optimum structural design of two-stage transmission gear system

Experimental Quantum Error-Free Transmission

Error-free transmission (EFT) of quantum information is a crucial ingredient in quantum communication network. To overcome the unavoidable decoherence in noisy channel, to date, many efforts have focused on faithfully transmitting one state by consuming large numbers of synchronized ancillary states. However, huge demands of quantum resources are hard to meet with current technology, thus restrict practical applications. Here we propose and demonstrate an economical method of reliably transmitting quantum information. An arbitrary unknown quantum state is converted into time bins deterministically in terms of its own polarization using a modified Franson interferometer. Any arisen noise in channel will induce an associated error to the reference frame of the time bins, which can be utilized to reject errors and recover the initial state. By virtue of state-independent feature, our method can be applied to entanglement distribution. After passing through 0.8 km randomly twisted optical fiber, the entanglement still survives and is verified. Our approach significantly simplifies the implementation of quantum EFT and enables a general quantum state even entanglement to be protected by feedback, thus can be used as a basic building block in practical long-distance quantum communication network.Comment: 18 pages, 3 figures, Submitted to Nature Communications, Under revie

Peripheral Leukocytapheresis Attenuates Acute Lung Injury Induced by Lipopolysaccharide In Vivo

The mortality of acute lung injury and acute respiratory distress syndrome (ALI/ARDS) remains high and efforts for prevention and treatments have shown little improvement over the past decades. The present study investigated the efficacy and mechanism of leukocytapheresis (LCAP) to partially eliminate peripheral neutrophils and attenuate lipopolysaccharide (LPS)-induced lung injury in dogs. A total of 24 healthy male mongrel dogs were enrolled and randomly divided into LPS, LCAP and LCAP-sham groups. All animals were injected with LPS to induce endotoxemia. The serum levels of leucocytes, neutrophil elastase, arterial blood gas, nuclear factor-kappa B (NF-κB) subunit p65 in lung tissues were measured. The histopathology and parenchyma apoptosis of lung tissues were examined. We found that 7, 3, and 7 animals in the LPS, LCAP, and sham-LCAP groups, respectively, developed ALI 36 h after LPS infusion. The levels of NF-κB p65 in lung tissue, neutrophils and elastase in blood, decreased significantly following LCAP. LCAP also alleviated apoptosis, and NF-κB p65 in lung tissues. Collectively, our results show that partial removal of leucocytes from peripheral blood decreases elastase level in serum. This, in turn, attenuates lung injuries and may potentially decrease the incidence of ALI

Anti-tumor activity of N-trimethyl chitosan-encapsulated camptothecin in a mouse melanoma model

<p>Abstract</p> <p>Background</p> <p>Camptothecin (CPT) has recently attracted increasing attention as a promising anticancer agent for a variety of tumors. But the clinical application is largely hampered by its extreme water insolubility and unpredictable side effect. It is essential to establish an efficient and safe protocol for the administration of CPT versus melanoma.</p> <p>Methods</p> <p>Camptothecin was encapsulated with N-trimethyl chitosan (CPT-TMC) through microprecipitation and sonication. Its inhibition effect on B16-F10 cell proliferation and induction of apoptosis was evaluated by MTT assay and flow cytometric analysis in vitro. The anti-tumor activity of CPT-TMC was evaluated in C57BL/6 mice bearing B16-F10 melanoma. Tumor volume, tumor weight and survival time were recorded. Assessment of apoptotic cells within tumor tissue was performed by TUNEL assay. Antiangiogenesis and antiproliferation effects of CPT-TMC in vivo were conducted via CD31 and PCNA immunohistochemistry, respectively.</p> <p>Results</p> <p>CPT-TMC efficiently inhibited B16-F10 cells proliferation and increased apoptosis in vitro. Experiment group showed significant inhibition compared with free CPT-treated group (81.3% vs. 56.9%) in the growth of B16-F10 melanoma xenografts and prolonged the survival time of the treated mice (P < 0.05). Decreased cell proliferation, increased tumor apoptosis as well as a reduction in angiogenesis were observed.</p> <p>Conclusions</p> <p>Our data suggest that N-trimethyl chitosan-encapsulated camptothecin is superior to free CPT by overcoming its insolubility and finally raises the potential of its application in melanoma therapy.</p