Transient pressure analysis of a volume fracturing well in fractured tight oil reservoirs

This research was supported by the Ministry of Land and Resources Special Geological Survey: Upper Paleozoic Marine Shale Gas Geological Survey in Yunnan, Guizhou, Guangxi Region (DD20160178), The Key Laboratory of Unconventional Petroleum Geology of Geological Survey of China Open Fund and the Major National R&D Projects: Study on the Test Method for Shale Structure and Composition at Different Scales with project number: 2016ZX05034-003-006.Peer reviewedPostprin

PD-1+ IFN-γ+ subset of CD8+ T cell in circulation predicts response to anti–PD-1 therapy in NSCLC

BackgroundTreatment with programmed cell death protein-1 (PD-1) antibodies has minimal response rates in patients with non–small cell lung cancer (NSCLC), and, actually, they are treated with chemotherapy combined with anti–PD-1 therapy clinically. Reliable markers based on circulating immune cell subsets to predict curative effect are still scarce.MethodsWe included 30 patients with NSCLC treated with nivolumab or atezolizumab plus platinum drugs between 2021 and 2022. Whole blood was collected at baseline (before treatment with nivolumab or atezolizumab). The percentage of circulating PD-1+ Interferon-γ (IFN-γ+) subset of CD8+ T cell was determined by flow cytometry. The proportion of PD-1+ IFN-γ+ was calculated after gating on CD8+ T cells. Neutrophil/lymphocyte ratio (NLR), relative eosinophil count (%), and Lactate dehydrogenase (LDH) concentration at baseline of included patients were extracted from electronic medical records.ResultsThe percentage of circulating PD-1+ IFN-γ+ subset of CD8+ T cell at baseline in responders was significantly higher than those in non-responders (P < 0.05). Relative eosinophil count (%) and LDH concentration in responders showed no significance between non-responders and responders. NLR in responders was significantly lower than those in non-responders (P < 0.05). Receiver operation characteristic (ROC) analysis found that the areas under the ROC curve for PD-1+ IFN-γ+ subset of CD8+ T cell and NLR were 0.7781 (95% CI, 0.5937–0.9526) and 0.7315 (95% CI, 0.5169–0.9461). Moreover, high percentage of PD-1+ IFN-γ+ subset in CD8+ T cells was relevant to long progression-free survival in patients with NSCLC treated with chemotherapy combined with anti–PD-1 therapy.ConclusionThe percentage of circulating PD-1+ IFN-γ+ subset of CD8+ T cell could be a potential marker at baseline to predict early response or progression in patients with NSCLC receiving chemotherapy combined with anti–PD-1 therapy

Targeting of Embryonic Stem Cells by Peptide-Conjugated Quantum Dots

Targeting stem cells holds great potential for studying the embryonic stem cell and development of stem cell-based regenerative medicine. Previous studies demonstrated that nanoparticles can serve as a robust platform for gene delivery, non-invasive cell imaging, and manipulation of stem cell differentiation. However specific targeting of embryonic stem cells by peptide-linked nanoparticles has not been reported.Here, we developed a method for screening peptides that specifically recognize rhesus macaque embryonic stem cells by phage display and used the peptides to facilitate quantum dot targeting of embryonic stem cells. Through a phage display screen, we found phages that displayed an APWHLSSQYSRT peptide showed high affinity and specificity to undifferentiated primate embryonic stem cells in an enzyme-linked immunoabsorbent assay. These results were subsequently confirmed by immunofluorescence microscopy. Additionally, this binding could be completed by the chemically synthesized APWHLSSQYSRT peptide, indicating that the binding capability was specific and conferred by the peptide sequence. Through the ligation of the peptide to CdSe-ZnS core-shell nanocrystals, we were able to, for the first time, target embryonic stem cells through peptide-conjugated quantum dots.These data demonstrate that our established method of screening for embryonic stem cell specific binding peptides by phage display is feasible. Moreover, the peptide-conjugated quantum dots may be applicable for embryonic stem cell study and utilization

Direct in situ synthesis of a 3D interlinked amorphous carbon nanotube/graphene/BaFe12O19 composite and its electromagnetic wave absorbing properties

2016-2017 > Academic research: refereed > Publication in refereed journalbcrcVersion of RecordPublishe

MIPI 2023 Challenge on RGBW Remosaic: Methods and Results

Developing and integrating advanced image sensors with novel algorithms in camera systems are prevalent with the increasing demand for computational photography and imaging on mobile platforms. However, the lack of high-quality data for research and the rare opportunity for an in-depth exchange of views from industry and academia constrain the development of mobile intelligent photography and imaging (MIPI). With the success of the 1st MIPI Workshop@ECCV 2022, we introduce the second MIPI challenge, including four tracks focusing on novel image sensors and imaging algorithms. This paper summarizes and reviews the RGBW Joint Remosaic and Denoise track on MIPI 2023. In total, 81 participants were successfully registered, and 4 teams submitted results in the final testing phase. The final results are evaluated using objective metrics, including PSNR, SSIM, LPIPS, and KLD. A detailed description of the top three models developed in this challenge is provided in this paper. More details of this challenge and the link to the dataset can be found at https://mipi-challenge.org/MIPI2023/.Comment: CVPR 2023 Mobile Intelligent Photography and Imaging (MIPI) Workshop--RGBW Sensor Remosaic Challenge Report. Website: https://mipi-challenge.org/MIPI2023/. arXiv admin note: substantial text overlap with arXiv:2209.08471, arXiv:2209.07060, arXiv:2209.07530, arXiv:2304.1008

MIPI 2022 Challenge on RGBW Sensor Re-mosaic: Dataset and Report

Developing and integrating advanced image sensors with novel algorithms in camera systems are prevalent with the increasing demand for computational photography and imaging on mobile platforms. However, the lack of high-quality data for research and the rare opportunity for in-depth exchange of views from industry and academia constrain the development of mobile intelligent photography and imaging (MIPI). To bridge the gap, we introduce the first MIPI challenge including five tracks focusing on novel image sensors and imaging algorithms. In this paper, RGBW Joint Remosaic and Denoise, one of the five tracks, working on the interpolation of RGBW CFA to Bayer at full resolution, is introduced. The participants were provided with a new dataset including 70 (training) and 15 (validation) scenes of high-quality RGBW and Bayer pairs. In addition, for each scene, RGBW of different noise levels was provided at 0dB, 24dB, and 42dB. All the data were captured using an RGBW sensor in both outdoor and indoor conditions. The final results are evaluated using objective metrics including PSNR, SSIM, LPIPS, and KLD. A detailed description of all models developed in this challenge is provided in this paper. More details of this challenge and the link to the dataset can be found at https://github.com/mipi-challenge/MIPI2022.Comment: ECCV 2022 Mobile Intelligent Photography and Imaging (MIPI) Workshop--RGBW Sensor Re-mosaic Challenge Report. MIPI workshop website: http://mipi-challenge.org/. arXiv admin note: substantial text overlap with arXiv:2209.07060, arXiv:2209.07530, arXiv:2209.0705

The optimal dose of oxycodone in PCIA after laparoscopic surgery for gastrointestinal cancer in elderly patients: A randomized controlled trial

ObjectiveTo explore the optimal bolus dose of oxycodone for patient controlled intravenous analgesia (PCIA) without background dose in elderly patients after laparoscopic surgery for gastrointestinal cancer.MethodsIn this prospective, randomized, double-blind, parallel-controlled study, we recruited patients aged 65 years or older. They underwent laparoscopic resection for gastrointestinal cancer and received PCIA after surgery. Eligible patients were randomly divided into 0.01, 0.02, or 0.03 mg/kg group according to the bolus dose of oxycodone in PCIA. The primary outcome was VAS scores of pain on mobilization at 48 h after surgery. Secondary endpoints included the VAS scores of rest pain, the total and effective numbers of press in PCIA, cumulative dose of oxycodone used in PCIA, the incidence of nausea, vomiting and dizziness, as well as patients’ satisfaction at 48 h after surgery.ResultsA total of 166 patients were recruited and randomly assigned to receive a bolus dose of 0.01 mg/kg (n = 55), 0.02 mg/kg (n = 56) or 0.03 mg/kg (n = 55) of oxycodone in PCIA. The VAS scores of pain on mobilization, the total and effective numbers of press in PCIA in 0.02 mg/kg group and 0.03 mg/kg group were lower than those in 0.01 mg/kg group (P < 0.05). Cumulative dose of oxycodone used in PCIA and patients’ satisfaction in 0.02 and 0.03 mg/kg groups were more than those in 0.01 mg/kg group (P < 0.01). The incidence of dizziness in 0.01 and 0.02 mg/kg groups was lower than that in 0.03 mg/kg group (P < 0.01). There were no significant differences in VAS scores of rest pain, the incidence of nausea and vomiting among three groups (P > 0.05).ConclusionFor elderly patients undergoing laparoscopic surgery for gastrointestinal cancer, 0.02 mg/kg bolus dose of oxycodone in PCIA without background infusion may be a better choice