An Interpretable Computer-Aided Diagnosis Method for Periodontitis From Panoramic Radiographs

Periodontitis is a prevalent and irreversible chronic inflammatory disease both in developed and developing countries, and affects about 20–50% of the global population. The tool for automatically diagnosing periodontitis is highly demanded to screen at-risk people for periodontitis and its early detection could prevent the onset of tooth loss, especially in local communities and health care settings with limited dental professionals. In the medical field, doctors need to understand and trust the decisions made by computational models and developing interpretable models is crucial for disease diagnosis. Based on these considerations, we propose an interpretable method called Deetal-Perio to predict the severity degree of periodontitis in dental panoramic radiographs. In our method, alveolar bone loss (ABL), the clinical hallmark for periodontitis diagnosis, could be interpreted as the key feature. To calculate ABL, we also propose a method for teeth numbering and segmentation. First, Deetal-Perio segments and indexes the individual tooth via Mask R-CNN combined with a novel calibration method. Next, Deetal-Perio segments the contour of the alveolar bone and calculates a ratio for individual tooth to represent ABL. Finally, Deetal-Perio predicts the severity degree of periodontitis given the ratios of all the teeth. The Macro F1-score and accuracy of the periodontitis prediction task in our method reach 0.894 and 0.896, respectively, on Suzhou data set, and 0.820 and 0.824, respectively on Zhongshan data set. The entire architecture could not only outperform state-of-the-art methods and show robustness on two data sets in both periodontitis prediction, and teeth numbering and segmentation tasks, but also be interpretable for doctors to understand the reason why Deetal-Perio works so well

Unicoder: A Universal Language Encoder by Pre-training with Multiple Cross-lingual Tasks

We present Unicoder, a universal language encoder that is insensitive to different languages. Given an arbitrary NLP task, a model can be trained with Unicoder using training data in one language and directly applied to inputs of the same task in other languages. Comparing to similar efforts such as Multilingual BERT and XLM, three new cross-lingual pre-training tasks are proposed, including cross-lingual word recovery, cross-lingual paraphrase classification and cross-lingual masked language model. These tasks help Unicoder learn the mappings among different languages from more perspectives. We also find that doing fine-tuning on multiple languages together can bring further improvement. Experiments are performed on two tasks: cross-lingual natural language inference (XNLI) and cross-lingual question answering (XQA), where XLM is our baseline. On XNLI, 1.8% averaged accuracy improvement (on 15 languages) is obtained. On XQA, which is a new cross-lingual dataset built by us, 5.5% averaged accuracy improvement (on French and German) is obtained.Comment: Accepted to EMNLP2019; 10 pages, 2 figure

Studies on Gas-phase Cyclometalations of [ArNi(PPh3)n]+ (n = 1 or 2) by Electrospray Ionization Tandem Mass Spectrometry

Gas-phase cyclometalation of [ArNi(PPh3)n]+ (n = 1, 2) complexes have been studied by ESI-MS/MS. The electron-donating substituents of aromatic iodides in the para position were found to inhibit the cyclometalation process of losing ArH, while the electron-withdrawing substituents in the para position were found to enhance it. These results indicate that the cyclometalation process of losing ArH is favored by electron-deficient aromatic groups. In addition, the detailed dissociation pathways of the cationic nickel complexes were studied, and among these pathways, the process of aryl-aryl interchange was also found to proceed in ESI-MS/MS