Deep Lesion Graphs in the Wild: Relationship Learning and Organization of Significant Radiology Image Findings in a Diverse Large-scale Lesion Database

Radiologists in their daily work routinely find and annotate significant abnormalities on a large number of radiology images. Such abnormalities, or lesions, have collected over years and stored in hospitals' picture archiving and communication systems. However, they are basically unsorted and lack semantic annotations like type and location. In this paper, we aim to organize and explore them by learning a deep feature representation for each lesion. A large-scale and comprehensive dataset, DeepLesion, is introduced for this task. DeepLesion contains bounding boxes and size measurements of over 32K lesions. To model their similarity relationship, we leverage multiple supervision information including types, self-supervised location coordinates and sizes. They require little manual annotation effort but describe useful attributes of the lesions. Then, a triplet network is utilized to learn lesion embeddings with a sequential sampling strategy to depict their hierarchical similarity structure. Experiments show promising qualitative and quantitative results on lesion retrieval, clustering, and classification. The learned embeddings can be further employed to build a lesion graph for various clinically useful applications. We propose algorithms for intra-patient lesion matching and missing annotation mining. Experimental results validate their effectiveness.Comment: Accepted by CVPR2018. DeepLesion url adde

The correlation between changes in gray matter microstructure and cerebral blood flow in Alzheimer’s disease

ObjectiveTo investigate the relationship between changes in cerebral blood flow (CBF) and gray matter (GM) microstructure in Alzheimer’s disease (AD) and mild cognitive impairment (MCI).MethodsA recruited cohort of 23 AD patients, 40 MCI patients, and 37 normal controls (NCs) underwent diffusional kurtosis imaging (DKI) for microstructure evaluation and pseudo-continuous arterial spin labeling (pCASL) for CBF assessment. We investigated the differences in diffusion- and perfusion-related parameters across the three groups, including CBF, mean diffusivity (MD), mean kurtosis (MK), and fractional anisotropy (FA). These quantitative parameters were compared using volume-based analyses for the deep GM and surface-based analyses for the cortical GM. The correlation between CBF, diffusion parameters, and cognitive scores was assessed using Spearman coefficients, respectively. The diagnostic performance of different parameters was investigated with k-nearest neighbor (KNN) analysis, using fivefold cross-validation to generate the mean accuracy (mAcc), mean precision (mPre), and mean area under the curve (mAuc).ResultsIn the cortical GM, CBF reduction primarily occurred in the parietal and temporal lobes. Microstructural abnormalities were predominantly noted in the parietal, temporal, and frontal lobes. In the deep GM, more regions showed DKI and CBF parametric changes at the MCI stage. MD showed most of the significant abnormalities among all the DKI metrics. The MD, FA, MK, and CBF values of many GM regions were significantly correlated with cognitive scores. In the whole sample, the MD, FA, and MK were associated with CBF in most evaluated regions, with lower CBF values associated with higher MD, lower FA, or lower MK values in the left occipital lobe, left frontal lobe, and right parietal lobe. CBF values performed best (mAuc = 0.876) for distinguishing the MCI from the NC group. Last, MD values performed best (mAuc = 0.939) for distinguishing the AD from the NC group.ConclusionGray matter microstructure and CBF are closely related in AD. Increased MD, decreased FA, and MK are accompanied by decreased blood perfusion throughout the AD course. Furthermore, CBF values are valuable for the predictive diagnosis of MCI and AD. GM microstructural changes are promising as novel neuroimaging biomarkers of AD

Improving the Classification Accuracy for Near-Infrared Spectroscopy of Chinese Salvia miltiorrhiza Using Local Variable Selection

In order to improve the classification accuracy of Chinese Salvia miltiorrhiza using near-infrared spectroscopy, a novel local variable selection strategy is thus proposed. Combining the strengths of the local algorithm and interval partial least squares, the spectra data have firstly been divided into several pairs of classes in sample direction and equidistant subintervals in variable direction. Then, a local classification model has been built, and the most proper spectral region has been selected based on the new evaluation criterion considering both classification error rate and best predictive ability under the leave-one-out cross validation scheme for each pair of classes. Finally, each observation can be assigned to belong to the class according to the statistical analysis of classification results of the local classification model built on selected variables. The performance of the proposed method was demonstrated through near-infrared spectra of cultivated or wild Salvia miltiorrhiza, which are collected from 8 geographical origins in 5 provinces of China. For comparison, soft independent modelling of class analogy and partial least squares discriminant analysis methods are, respectively, employed as the classification model. Experimental results showed that classification performance of the classification model with local variable selection was obvious better than that without variable selection

Energy efficient and distributed resource allocation for wireless powered OFDMA multi-cell networks

In this paper, we investigate the energy efficient resource allocation problem for the wireless powered OFDMA multi-cell networks. In the considered system, the users who have data to transmit in the uplink can only be empowered by the wireless power obtained from multiple base stations (BSs) with a large scale of multiple antennas in the downlink. A time division protocol is considered to divide the time of wireless power transfer (WPT) in the downlink and wireless information transfer (WIT) in the uplink into separate time slot. With the objective to improve the energy efficiency (EE) of the system, we propose the antenna selection, time allocation, subcarrier and power allocation schemes. Due to the non-convexity of the formulated optimization problem, we first apply the nonlinear programming scheme to convert it to a convex optimization problem and then address it through an efficient alternating direction method of multipliers based distributed resource allocation algorithm. Extensive simulations are conducted to show the effectiveness of proposed schemes.peerReviewe

Local Strategy Combined with a Wavelength Selection Method for Multivariate Calibration

One of the essential factors influencing the prediction accuracy of multivariate calibration models is the quality of the calibration data. A local regression strategy, together with a wavelength selection approach, is proposed to build the multivariate calibration models based on partial least squares regression. The local algorithm is applied to create a calibration set of spectra similar to the spectrum of an unknown sample; the synthetic degree of grey relation coefficient is used to evaluate the similarity. A wavelength selection method based on simple-to-use interactive self-modeling mixture analysis minimizes the influence of noisy variables, and the most informative variables of the most similar samples are selected to build the multivariate calibration model based on partial least squares regression. To validate the performance of the proposed method, ultraviolet-visible absorbance spectra of mixed solutions of food coloring analytes in a concentration range of 20–200 µg/mL is measured. Experimental results show that the proposed method can not only enhance the prediction accuracy of the calibration model, but also greatly reduce its complexity

Energy efficient optimisation for large-scale multiple-antenna system with WPT

In this study, an energy-efficient optimisation scheme for a large-scale multiple-antenna system with wireless power transfer (WPT) is presented. In the considered system, the user is charged by a base station with a large number of antennas via downlink WPT and then utilises the received power to carry out uplink data transmission. Novel antenna selection, time allocation and power allocation schemes are presented to optimise the energy efficiency of the overall system. In addition, the authors also consider channel state information cannot be perfectly obtained when designing the resource allocation schemes. The non-linear fractional programming-based algorithm is utilised to address the formulated problem. Their proposed schemes are validated by extensive simulations and it shows superior performance over the existing schemes.peerReviewe

Distributed Resource Allocation for Energy Efficiency in OFDMA Multicell Networks with Wireless Power Transfer

In this paper, an energy-efficient resource allocation problem is investigated for the wireless power transfer (WPT)-enabled OFDMA multicell networks. In the considered system, multiple base stations (BSs) with a large number of antennas are responsible to provide WPT in the downlink, and the users can recycle and utilize the received energy for uplink data transmission. The role of BS is to execute WPT; thus, there are no data transmissions in the downlink. A time-division protocol is considered to divide the time of downlink WPT and uplink wireless information transfer into separate time slots. With the objective to improve the energy efficiency, we propose the time, subcarrier, and power allocation schemes and antenna selection algorithms. As the perfect channel state information (CSI) is hard to obtain in the practical systems, we also take the case where only estimated CSI is available into consideration when executing resources allocation decisions and analyze the corresponding performance. Due to the non-convexity of the formulated optimization problem, we first apply the nonlinear programming scheme to convert it to a convex optimization problem. Then, an efficient alternating direction method of multipliers-based distributed resource allocation algorithm is applied to address the transformed problem. Performance evaluations are conducted to demonstrate the advantages of the proposed schemes.peerReviewe