Distributed Event-Triggered Nonlinear Fusion Estimation under Resource Constraints

This paper studies the event-triggered distributed fusion estimation problems for a class of nonlinear networked multisensor fusion systems without noise statistical characteristics. When considering the limited resource problems of two kinds of communication channels (i.e., sensor-to-remote estimator channel and smart sensor-to-fusion center channel), an event-triggered strategy and a dimensionality reduction strategy are introduced in a unified networked framework to lighten the communication burden. Then, two kinds of compensation strategies in terms of a unified model are designed to restructure the untransmitted information, and the local/fusion estimators are proposed based on the compensation information. Furthermore, the linearization errors caused by the Taylor expansion are modeled by the state-dependent matrices with uncertain parameters when establishing estimation error systems, and then different robust recursive optimization problems are constructed to determine the estimator gains and the fusion criteria. Meanwhile, the stability conditions are also proposed such that the square errors of the designed nonlinear estimators are bounded. Finally, a vehicle localization system is employed to demonstrate the effectiveness and advantages of the proposed methods.Comment: 15 pages,9 figures. The first draft was completed in June 2021, and this is the revised versio

A Fully Integrated Solid-State Charge Detector with through Fused Silica Glass via Process

A charge detector is a vital component in neutrino and dark matter detection. The integration of a charge collector in the form of flat pads and readout modules has been proposed as an optimization method as it can reduce noise and installation complexity. As a substrate, fused silica glass has attracted considerable attention due to its low radioactive background properties. In this research, based on the application requirements of a high charge collection rate and low noise, the structure of the charge detector was designed using calculation and simulation methods. The entire manufacturing process is described. In addition, a novel through glass via (TGV) structure composed of a conformal metal layer and a photosensitive material that is easy to fabricate and has high morphological compatibility with via filling is proposed. The curing property of the new material was characterized. A fully integrated solid-state charge detector with 32 groups of TGVs was realized. Additionally, the electrical properties of key structures were tested and analyzed

Quantification of host proteomic responses to genotype 4 hepatitis E virus replication facilitated by pregnancy serum

Abstract Background Hepatitis E virus (HEV) infection is a common cause of acute hepatitis worldwide and causes approximately 30% case fatality rate among pregnant women. Pregnancy serum (PS), which contains a high concentration of estradiol, facilitates HEV replication in vitro through the suppression of the PI3K–AKT–mTOR and cAMPK–PKA–CREB signaling pathways. However, the proteomics of the complex host responses to HEV infection, especially how PS facilitates viral replication, remains unclear. Methods In this study, the differences in the proteomics of HEV-infected HepG2 cells supplemented with fetal bovine serum (FBS) from those of HEV-infected HepG2 cells supplemented with serum from women in their third trimester of pregnancy were quantified by using isobaric tags for relative and absolute quantification technology. Results A total of 1511 proteins were identified, among which 548 were defined as differentially expressed proteins (DEPs). HEV-infected cells supplemented with PS exhibited the most significant changes at the protein level. A total of 328 DEPs, including 66 up-regulated and 262 down-regulated proteins, were identified in HEV-infected cells supplemented with FBS, whereas 264 DEPs, including 201 up-regulated and 63 down-regulated proteins, were found in HEV-infected cells supplemented with PS. Subsequently, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses revealed that in HEV-infected cells, PS supplementation adjusted more host genes and signaling pathways than FBS supplementation. The DEPs involved in virus–host interaction participated in complex interactions, especially a large number of immune-related protein emerged in HEV-infected cells supplemented with PS. Three significant or interesting proteins, including filamin-A, thioredoxin, and cytochrome c, in HEV-infected cells were functionally verified. Conclusions The results of this study provide new and comprehensive insight for exploring virus–host interactions and will benefit future studies on the pathogenesis of HEV in pregnant women