Epithelial-Mesenchymal Transition and its Regulation in Tumor Metastasis

Epithelial-mesenchymal transition (EMT) plays a key role in cancer metastasis. This process is a complex, multi-functional, and tightly regulated developmental program. EMT has been extensively investigated, but the molecular regulation of its signaling pathway is highly complex. In this study, the different elements of EMT cascades that could be targeted were determined. Difficulties in translating the preclinical findings in routine clinic were also distinguished. Future research will provide insights into the activation and regulation of various EMT programs in different tumor types and at distinct stages of tumor development. These results will likely facilitate the development of early detection strategies and improve the therapeutic targeting of malignant solid tumors

THE DYNAMIC LOAD ON HAMSTRING MUSCLES DURING SPRINTING

The purpose of this study was to analyze the load condition on hamstring muscles during stance and swing phase of sprinting. Three-dimensional videographic and ground reaction force data were collected and the intersegmental dynamics of lower limb was quantified while eight elite male sprint runners performed sprint running with maximum effort. During initial stance phase, the ground reaction torque (EXT) was the main passive torque at knee and hip. During late swing phase, it was motion-dependent torque (MDT) as well. The muscle torques counteracted the large effect of EXT and MDT. This result revealed that the hamstring muscles would suffer from tremendous loads in both initial stance phase and late swing phase. Thus it can be speculated that hamstring muscles were exposed to a higher risk of injury during these two phases in sprinting

2,5-Bis[(3-chloro­benz­yl)sulfan­yl]-1,3,4-thia­diazole

The complete mol­ecule of the title compound, C16H12Cl2N2S3, is generated by crystallographic twofold symmetry, with the S atom of the thiadiazole ring lying on the rotation axis. The dihedral angle between the mean planes of the 1,3,4-thia­diazole and benzene rings is 87.19 (7)°. In the crystal, mol­ecules are linked by C—H⋯N inter­actions and short S⋯S contacts [3.3389 (9) Å] occur