Design of novel intrinsically safe power supply with 'ia' grade

According to working condition of mine-used power supply in coal mine underground, novel intrinsically safe power supply with 'ia' grade was designed. The power supply uses a fully enclosed AC-DC module to eliminate special flameproof enclosure, and has over-voltage protection circuit of dual redundancy and over-current protection circuit of three redundancy. The experimental results show there is no spark when the power supply load is short circuited under the conditions of no fault, one counting fault and two counting faults, which realizes intrinsic safety

Effect of Patient Decision Aids in the Diagnosis and Treatment of Colorectal Cancer: a Systematic Review

Background Patient decision aids (PDAs) are essential tools to assist patients in the process of shared-decision making. However, their effects have been reported to be inconsistent in shared-decision making in the diagnosis and treatment of colorectal cancer. Objective To assess the core factors in the development of PADs supporting decision-making in colorectal cancer diagnosis and treatment, and their application effects using a systematic review. Methods In February 2022, randomized controlled trials (RCTs) on PDAs supporting decision-making in colorectal cancer care were searched in databases including PubMed, Web of Science, CIHNAL, Cochrane Library, EmBase, PsycINFO, JBI, Scopus, CNKI, WanFang, CQVIP and SinoMed from inception to January, 2022. Two researchers performed literature screening and data extraction separately. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials (5.1.0) was used to assess the risk of bias. A descriptive analysis was conducted to describe the core factors used in the development of PDAs and to summarize the effect of PDAs. Results A total of 11 RCTs were included, involving PDAs for supporting decision-making in colorectal cancer screening, systemic therapy and supportive care for advanced colorectal cancer, chemotherapy for metastatic colorectal cancer, and genetic testing for hereditary nonpolyposis colorectal cancer. The quality was moderate on the whole. Specifically, the quality of one RCT was rated as level A and that of the other 10 was level B. The analysis found that: (1) currently, the development of PDAs for supporting decision-making in colorectal cancer is mainly under the guidance of the quality criteria framework published by the International Patient Decision Aids Standards Collaboration, and the core content of the tool include providing information about options, balanced presentation of options, clarifying and expressing values; (2) The use of PDAs increased patient knowledge (six RCTs) , reduced patient decisional conflicts (eight RCTs) and promoted informed choice (two RCTs) . Conclusion The use of PDAs has proven to be effective in improving patient decision-making behavior and results in colorectal cancer. Although the evidence is still insufficient, they have broad prospect in clinical practice. In the future, the PDAs that are applicable to Chinese patients in different stages of colorectal cancer can be developed with the support of foreign theoretical achievements about decision-making and in accordance with the conditions of Chinese population, and the application effects of them need to be assessed further

A novel chopping current protection circuit for intrinsically safe power supply

For problems that traditional chopping current protection circuit had small cut-off current value and poor anti load impact ability, and needed additional recovery circuit or manual circuit after over-current fault, a novel chopping current protection circuit for intrinsically safe power supply was designed. The circuit adopts double parallel control structure, so as to improve reliability. The circuit can chop circuit rapidly under condition of load over flowing, and put into operation fast after fault with adjusted input point. Meanwhile, the circuit has low power consumption part, so as to reduce power loss under condition of light load or no-load. The experimental results show that the circuit can recover automatically after over-current fault with low load effect and strong load capacity

Analysis of the Fruit Quality of Pear (Pyrus spp.) Using Widely Targeted Metabolomics

Pear is a kind of common temperate fruit, whose metabolite composition that contributes to the difference in fruit quality is unclear. This study identified and quantified the metabolites using a widely targeted LC-MS/MS approach in three pear species, including Pyrus bretschneideri (PB), Pyrus usssuriensis (PU) and Pyrus pyrifolia (PP). A total of 493 metabolites were identified, consisting of 68 carbohydrates, 47 organic acids, 50 polyphenols, 21 amino acids, 20 vitamins, etc. The results of PCA and OPLS-DA demonstrated that the metabolite compositions differed distinctly with cultivar variability. Our results also involved some metabolic pathways that may link to the fruit quality based on KEGG pathway analysis, the pathway of phenylalanine metabolism revealed significant differences between PB and PP (p < 0.05). Furthermore, the study selected D-xylose, formononetin, procyanidin A1 and β-nicotinamide mononucleotide as the major differentially expressed metabolites in the three species. The present study can open new avenues for explaining the differences in fruit quality of the major commercial pear cultivars in China

Overcoming laser phase noise for low-cost coherent optical communication

Abstract Artificial-intelligence-generated content has driven explosive data traffic growth in data-center interconnects. Traditional direct detection solutions struggle with limited spectral efficiency and distance, prompting the shift to coherent optics for cost-sensitive short-reach links. One specific challenge is integrating low-cost lasers while overcoming severe phase noise on high-order modulation formats. Here, we propose a residual carrier modulation scheme for precise and efficient carrier frequency and phase recovery. The residual optical carrier can continuously track phase fluctuations without redundancy compared with discrete time-domain pilots, and address the digital-to-analog convertor resolution reduction issue of frequency-domain digital pilots. In proof-of-concept experiments, we transmit a net 1-Tb/s probabilistic-shaped 256-ary quadrature amplitude modulated (PS-256-QAM) signal using a 3 MHz distributed feedback (DFB) laser. Our scheme improves bitrate by 41% compared to conventional time-domain pilots, achieving a record laser linewidth sum and symbol duration product of 6.89 × 10−5. This approach supports MHz linewidth DFB lasers in low-cost coherent optical communications

LncRNA HOTAIR is a Prognostic Biomarker for the Proliferation and Chemoresistance of Colorectal Cancer via MiR-203a-3p-Mediated Wnt/ß-Catenin Signaling Pathway

Background/Aims: HOX transcript antisense RNA (HOTAIR) plays a vital role in carcinogenesis. However, its functional and regulatory roles remain unclear. In this study, we aimed to investigate its biological function and clinical significance in human colorectal cancer (CRC). Methods: We examined the expression levels of lncRNA HOTAIR and miR-203a-3p in CRC tissues and CRC cell lines by qRT-PCR. Gain and loss-of-function assays were performed to examine the effects of HOTAIR and miR-203a-3p on the proliferation and chemoresistance of CRC cells. The possible mechanisms of HOTAIR were also explored by fluorescence reporter assay and Western blot. Results: The expressions of HOTAIR were upregulated in CRC tissue tissues compared to adjacent control tissues. We also found HOTAIR was downregulated by miR-203a-3p in CRC cell lines. Both HOTAIR knockdown and miR-203a-3p overexpression in CRC cell lines led to inhibited cell proliferation and reduced chemoresistance. We also determined that β-catenin and GRG5 were inhibitory targets of miR-203a-3p, and that Wnt/β-catenin signaling was inhibited by both HOTAIR knockdown and miR-203a-3p overexpression. Significantly, we found that increased expression of miR-203a-3p is essential for cell proliferation repression, chemoresistance reduction, and Wnt/β-catenin signaling inhibition induced by HOTAIR knockdown. Conclusions: Our study demonstrated that the lncRNA HOTAIR could regulate the progression and chemoresistance of CRC via modulating the expression levels of miR-203a-3p and the activity of Wnt/β-catenin signaling pathway

Research on Pump Inspection Cycle Early Warning Method Based on Big Data

At present, the existing indicator diagram can only be used for expost judgment and can not give early warning, and the influencing factors of pump inspection period are nonlinear, multi constrained and multi variable. In this paper, big data machine learning method is used to carry out relevant research. Firstly, around the influencing factors of pump inspection cycle, relevant data are collected and the evaluation index of pump inspection cycle is designed. Then, based on feature engineering technology, the production parameters of oil wells in different pump inspection periods are calculated to form the analysis sample set of pump inspection period. Finally, the early warning model of pump inspection period is established by using machine learning technology. The experimental results show that: the pump inspection cycle early warning model established by stochastic forest algorithm can identify the pump inspection status of single well, and the accuracy rate is about 85%

An asymmetrical connection balance transformer-based hybrid railway power conditioning system with cost-function optimization

For solving the emerging power quality problems in electrified railway, an asymmetrical connection balance transformer-based hybrid railway power conditioning system with cost-function optimization (ACBT-HRPC) is proposed in this paper. Compared with other balanced traction transformers, the ACBT is characterized with a much higher material utilization, which really matters in practical applications. Besides, the inductively filtered rectifier transformer, with filter-tuned branches used for filtering harmonics and compensating reactive power, is used as a coupling stage of hybrid railway power conditioning system. The mathematical relationship between power factor and design capacity is analyzed, and the cost-function optimization has been proposed to minimize the investment of ACBT-HRPC, which enables a satisfactory compensation performance with relatively attractive costs. Both the simulation and experimental results verify the effectiveness of ACBT-HRPC