Comprehensive Analysis, Discussion and Suggestion on the Current Situation of Cardiopulmonary Resuscitation and Automatic External Defibrillator in General Public in China

The number of sudden cardiac death (SCD) has increased year by year, which has become one of the main causes of death in China. Timely cardiopulmonary resuscitation (CPR) and timely and accurate use of automatic external defibrillator (AED) can greatly improve the survival rate of patients with sudden cardiac death. Because the large probability of sudden cardiac death occurs outside the hospital, it is very important for the general public to master first aid skills. This paper will mine all kinds of data from multi-dimensional and multi-angle, analyze the mastery of public first aid skills in China, and provide practical suggestions and ideas for popularizing first aid skills in the future

Research Progress of Vitamin D and Autoimmune Diseases

As a fat-soluble vitamin, Vitamin D is a necessary hormone to maintain normal physiological activities of the body. In recent years, vitamin D has been considered as a new neuroendocrine-immunomodulatory hormone, and researchers have paid more attention to the study of immune regulatory mechanism. It is not only related to calcium and phosphorus metabolism, bone metabolism and other important metabolic mechanisms of the body, but also closely related to the immune regulation mechanism of the body. Vitamin D deficiency caused by many factors can play a certain role in the development of autoimmune diseases. In this paper, the related mechanisms of vitamin D affecting autoimmune diseases were reviewed, with a view to expound the close correlation between vitamin D and autoimmune diseases, so as to find new diagnosis and treatment approaches for clinical autoimmune diseases and improve the quality of life of patients with autoimmune diseases

Advances in Single Nucleotide Polymorphisms of Vitamin D Metabolic Pathway Genes and Respiratory Diseases

Vitamin D is a fat-soluble vitamin. It is an essential vitamin for human body. It has a classical effect on regulating calcium and phosphorus metabolism. Participate in cellular and humoral immune processes by regulating the growth, differentiation and metabolism of immune cells. A large number of studies in recent years have shown that vitamin D deficiency increases the incidence of respiratory diseases. Respiratory diseases mainly include bronchial asthma, chronic obstructive pulmonary disease, tuberculosis, acute upper respiratory tract infection and pneumonia. Vitamin D metabolic pathway genes play a very important regulatory role in the transformation of vitamin D into active vitamin D, including CYP2R1,,CYP27B1, CYP24A1, VDBP, VDR five genes. Genetic polymorphism of genes is the molecular basis of individual differences and disease development. Therefore, this paper summarizes the research on single nucleotide polymorphism of vitamin D metabolic pathway gene and respiratory diseases. In order to provide a new idea for future treatment

Research Progress of Vitamin D and Pathogenesis of Bronchial Asthma

At present the incidence of bronchial asthma on the rise, its pathogenesis and the genetic immune and the relationship between social environment and other aspects are inseparable the activity of vitamin D (Vit D) in the body in the form of 1, 25 - (OH) 2 d3, mainly involved in bone metabolism and calcium absorption in addition to this, a growing number of studies show that in Vit D plays an important role in the pathogenesis of bronchial asthma, play a role in the immune function of bronchial asthma growth hormone sensitivity adjustment and airway remodeling in this paper, the development of a variety of mechanisms, such as Vit D. Review the possible mechanisms affecting bronchial asthma, hoping to provide adjuvant treatment for patients with bronchial asthma, discover new treatment approaches, and improve the quality of life for patients

Research Progress on the Relationship between Polymorphism and SLE of Vitamin D Metabolic Pathway Related Gene

Vitamin D is a class of hormones necessary to maintain normalphysiological activities of the body. A large number of studies have shownthat vitamin D, as a fat-soluble vitamin, is not only related to calcium andphosphorus metabolism, but also closely related to immune regulation,humoral regulation, cell cycle and so on. Systemic Lupus erythema-Tosus(SLE) is a specific autoimmune diffuse connective tissue disease thatcauses tissue and organ damage under the joint action of multiple factorssuch as environment and heredity. Among many factors, the vitamin Dmetabolism pathway gene is particularly important for its influence. Someliterature has shown that the genetic polymorphism of vitamin D metabolicpathway genes is correlated with SLE. Therefore, by referring to relevantliterature, this paper summarized the progress in the research on themechanism of genetic polymorphism of vitamin metabolism pathway genesand the development of SLE

Study on the Role of Vitamin D in Systemic Lupus Erythematosus

Vitamin D is a hormone precursor with multiple biological effects. It binds to vitamin D receptors on target cells. It is an important participant in the metabolism of calcium and phosphorus in vivo. It is closely related to cell cycle, cell proliferation, differentiation, apoptosis, signal transduction and immune regulation. Its role in the treatment of infection, tumor and even immune diseases has been gradually recognized and studied. Patients with systemic lupus erythematosus generally have decreased levels of active vitamin D, and low levels of vitamin D are associated with disease occurrence, disease activity and complications. In the past ten years, a large number of studies have been carried out on it globally to explore the role of vitamin D in the occurrence and development of systemic lupus erythematosus. This paper summarizes its recent research progress

Metformin and Lactic Acidosis in Diabetic Patients

Metformin is the basic drug in the clinical treatment of Diabetes, often used in the treatment of Type 2 Diabetes Mellitus (T2DM).Its effect has been fully verified in the clinical treatment of T2DM. However, in the treatment of T2DM with metformin, there is still a certain probability of related lactic acidosis, and the fatality rate is high. Therefore, is the use of metformin drug treatment a direct risk factor for lactic acidosis in diabetic patients? This paper will review the hypoglycemic mechanism of metformin and related studies on lactic acidosis, so as to further explore the relationship between metformin and lactic acidosis in diabetic patients, and provide help and reference for metformin drugs in the clinical treatment of T2DM

Effect of Metformin on Lactate Metabolism in Normal Hepatocytes under High Glucose Stress in Vitro

Objective: To study the effect of metformin on lactate metabolism in hepatocytes in vitro under high glucose stress. Method: LO2 hepatocytes was cultured in vitro, hepatocytes were randomly divided into blank control group, 25 mmol/L glucose solution, 27 mmol/L glucose solution, 29 mmol/L glucose solution, 31 mmol/L glucose solution, 33 mmol/L glucose solution, 35 mmol/L glucose solution treatment group, after determining the optimal concentration as 31 mmol/L, use 30 mmol/L metformin solution, and then divided into blank control group, normal hepatocytes + the optimal concentration of glucose solution, normal hepatocytes + metformin solution , normal hepatocytes+. The optimal concentration of glucose solution normal hepatocytes + metformin solution, calculate the number of hepatocytes on cell count plate respectively in the 12 h, 24 h, 48 h, and use the lactic acid kit to determine the lactic acid value of the cell culture medium of normal liver cells + optimal concentration glucose solution and normal liver cells + optimal concentration glucose solution + metformin solution at 12 h, 24 h, and 48 h, respectively. Results: There was no significant change in the lactic acid concentration but significant increase in the number of surviving hepatocytes in the high-glycemic control group compared with that in the high-glycemic control group without metformin. Conclusions: Metformin has no significant effect on lactic acid metabolism of hepatocytes under high glucose stress in vitro, and has a protective effect on hepatocytes under high glucose stress. Based on this, it is preliminarily believed that metformin is not the direct factor leading to diabetic lactic acidosis

Spatially Adaptive Self-Supervised Learning for Real-World Image Denoising

Significant progress has been made in self-supervised image denoising (SSID) in the recent few years. However, most methods focus on dealing with spatially independent noise, and they have little practicality on real-world sRGB images with spatially correlated noise. Although pixel-shuffle downsampling has been suggested for breaking the noise correlation, it breaks the original information of images, which limits the denoising performance. In this paper, we propose a novel perspective to solve this problem, i.e., seeking for spatially adaptive supervision for real-world sRGB image denoising. Specifically, we take into account the respective characteristics of flat and textured regions in noisy images, and construct supervisions for them separately. For flat areas, the supervision can be safely derived from non-adjacent pixels, which are much far from the current pixel for excluding the influence of the noise-correlated ones. And we extend the blind-spot network to a blind-neighborhood network (BNN) for providing supervision on flat areas. For textured regions, the supervision has to be closely related to the content of adjacent pixels. And we present a locally aware network (LAN) to meet the requirement, while LAN itself is selectively supervised with the output of BNN. Combining these two supervisions, a denoising network (e.g., U-Net) can be well-trained. Extensive experiments show that our method performs favorably against state-of-the-art SSID methods on real-world sRGB photographs. The code is available at https://github.com/nagejacob/SpatiallyAdaptiveSSID.Comment: CVPR 2023 Camera Read

Effect of Metformin on Lactate Metabolism in Normal Hepatocytes under High Glucose Stress in Vitro

Objective To study the effect of metformin on lactate metabolism in hepatocytes in vitro under high glucose stress. In vitro LO2 cells, liver cells were randomly divided into blank control group, 25 tendency/L glucose solution, 27 tendency/L glucose solution,29 tendency/L glucose solution, 31 tendency/L glucose solution, 33 tendency/L glucose solution,35 tendency/L glucose solution treatment group, the optimal concentration of 31 tendency after L, use 30 tendency for L metformin solution, and then divided into blank control group, the optimal concentration of glucose solution, normal liver cells + metformin solution normal liver cells. The optimal concentration of glucose solution normal liver cells + metformin solution respectively in the 12 h, 24 h,48 h on cell count plate to calculate the number of liver cells, and using lactic acid determination kit the optimal concentration of glucose solution + normal liver cells and normal liver cells + the optimal concentration of glucose solution + metformin solution respectively in the 12 h, 24 h, 48 h of cell cultures of lactic acid value. There was no significant change in the lactic acid concentration but significant increase in the number of surviving hepatocytes in the highglycemic control group compared with that in the high-glycemic control group without metformin. Metformin has no significant effect on lactic acid metabolism of hepatocytes under high glucose stress in vitro, and has a protective effect on hepatocytes under high glucose stress. Based on this,it is preliminarily believed that metformin is not the direct factor leading to diabetic lactic acidosis