GST Compliance costs in Singapore : development of an interactive websurvey.

There is an increase in interest in the area of tax compliance costs research. This report documents the design and flow of questions of an Web-based internet survey on measuring GST Compliance costs for businesses in Singapore. It is meant to be a platform for future researchers to improvise on the survey and conduct the survey. The rationale of using Internet is because of its interactiveness, whereby questions can be customized, removing the irrelevent questions. It would be a pioneer survey and also offers the potential for a large scale survey to be conducted. We hope that this can help to reduce the compliance costs on GST for businesses in the future

Natural Products in Preventing Tumor Drug Resistance and Related Signaling Pathways

Drug resistance is still an obstacle in cancer therapy, leading to the failure of tumor treatment. The emergence of tumor drug resistance has always been a main concern of oncologists. Therefore, overcoming tumor drug resistance and looking for new strategies for tumor treatment is a major focus in the field of tumor research. Natural products serve as effective substances against drug resistance because of their diverse chemical structures and pharmacological effects. We reviewed the signaling pathways involved in the development of tumor drug resistance, including Epidermal growth factor receptor (EGFR), Renin-angiotensin system (Ras), Phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt), Wnt, Notch, Transforming growth factor-beta (TGF-β), and their specific signaling pathway inhibitors derived from natural products. This can provide new ideas for the prevention of drug resistance in cancer therapy