Super-resolution imaging through a multimode fiber: the physical upsampling of speckle-driven

Following recent advancements in multimode fiber (MMF), miniaturization of imaging endoscopes has proven crucial for minimally invasive surgery in vivo. Recent progress enabled by super-resolution imaging methods with a data-driven deep learning (DL) framework has balanced the relationship between the core size and resolution. However, most of the DL approaches lack attention to the physical properties of the speckle, which is crucial for reconciling the relationship between the magnification of super-resolution imaging and the quality of reconstruction quality. In the paper, we find that the interferometric process of speckle formation is an essential basis for creating DL models with super-resolution imaging. It physically realizes the upsampling of low-resolution (LR) images and enhances the perceptual capabilities of the models. The finding experimentally validates the role played by the physical upsampling of speckle-driven, effectively complementing the lack of information in data-driven. Experimentally, we break the restriction of the poor reconstruction quality at great magnification by inputting the same size of the speckle with the size of the high-resolution (HR) image to the model. The guidance of our research for endoscopic imaging may accelerate the further development of minimally invasive surgery

An M2e-based multiple antigenic peptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses

<p>Abstract</p> <p>Background</p> <p>A growing concern has raised regarding the pandemic potential of the highly pathogenic avian influenza (HPAI) H5N1 viruses. Consequently, there is an urgent need to develop an effective and safe vaccine against the divergent H5N1 influenza viruses. In the present study, we designed a tetra-branched multiple antigenic peptide (MAP)-based vaccine, designated M2e-MAP, which contains the sequence overlapping the highly conserved extracellular domain of matrix protein 2 (M2e) of a HPAI H5N1 virus, and investigated its immune responses and cross-protection against different clades of H5N1 viruses.</p> <p>Results</p> <p>Our results showed that M2e-MAP vaccine induced strong M2e-specific IgG antibody responses following 3-dose immunization of mice with M2e-MAP in the presence of Freunds' or aluminium (alum) adjuvant. M2e-MAP vaccination limited viral replication and attenuated histopathological damage in the challenged mouse lungs. The M2e-MAP-based vaccine protected immunized mice against both clade1: VN/1194 and clade2.3.4: SZ/406H H5N1 virus challenge, being able to counteract weight lost and elevate survival rate following lethal challenge of H5N1 viruses.</p> <p>Conclusions</p> <p>These results suggest that M2e-MAP presenting M2e of H5N1 virus has a great potential to be developed into an effective subunit vaccine for the prevention of infection by a broad spectrum of HPAI H5N1 viruses.</p

Therapeutic androgen receptor ligands

In the past several years, the concept of tissue-selective nuclear receptor ligands has emerged. This concept has come to fruition with estrogens, with the successful marketing of drugs such as raloxifene. The discovery of raloxifene and other selective estrogen receptor modulators (SERMs) has raised the possibility of generating selective compounds for other pathways, including androgens (that is, selective androgen receptor modulators, or SARMs)

TRANSTENSIONAL MECHANISM ANALYSIS OF FORKLIFT TRANSMISSION WHEEL HUB STUD

By mechanical analysis to analyze the mechanism of wheel hub stud rotating and transtensional when taking strenuous test to forklift transmission,if pre-tightening force between rim and wheel hub is not enough because of the unqualified nut,Ground braking force is more than friction force when truck brakes,rim rotates to the brake drum and nut,wheel hub stud bears extra twisting force between rim and nut,causing wheel hub stud rotating and transtesional. Learning the mechanism of wheel hub stud rotating and transtensional is helpful to know further the wheel hub stud working force condition,and it can give theoretical basis to the failure analysis of wheel hub stud and nu

Inconsistency distribution patterns of different remote sensing land-cover data from the perspective of ecological zoning

Analyzing consistency of different land-cover data is significant to reasonably select land-cover data for regional development and resource survey. Existing consistency analysis of different datasets mainly focused on the phenomena of spatial consistency regional distribution or accuracy comparison to provide guidelines for choosing the land-cover data. However, few studies focused on the hidden inconsistency distribution rules of different datasets, which can provide guidelines not only for users to properly choose them but also for producers to improve their mapping strategies. Here, we zoned the Sindh province of Pakistan by the Terrestrial Ecoregions of the World as a case to analyze the inconsistency patterns of the following three datasets: GlobeLand30, FROM-GLC, and regional land cover (RLC). We found that the inconsistency of the three datasets was relatively low in areas having a dominant type and also showing homogeneity characteristics in remote sensing images. For example, cropland of the three datasets in the ecological zoning of Northwestern thorn scrub forests showed high consistency. In contrast, the inconsistency was high in areas with strong heterogeneity. For example, in the southeast of the Thar desert ecological zone where cropland, grassland, shrubland, and bareland were interleaved and the surface cover complexity was relatively high, the inconsistency of the three datasets was relatively high. We also found that definitions of some types in different classification systems are different, which also increased the inconsistency. For example, the definitions of grassland and bareland in GlobeLand30 and RLC were different, which seriously affects the consistency of these datasets. Hence, producers can use the existing land-cover products as reference in ecological zones with dominant types and strong homogeneity. It is necessary to pay more attention on ecological zoning with complex land types and strong heterogeneity. An effective way is standardizing the definitions of complex land types, such as forest, shrubland, and grassland in these areas

Consistency Analysis of Remote Sensing Land Cover Products in the Tropical Rainforest Climate Region: A Case Study of Indonesia

Land cover changes in tropical rainforest climate zones play an important role in global climate change and the functioning of the Earth’s natural system. Existing research on the consistency of different land cover products has mainly focused on administrative divisions (continental or national scales). However, the ongoing production of large regional or global land cover products with higher resolutions requires us to have a better grasp of confusing land types and their geographical locations for different zoning (e.g., geographical zoning) in order to guide the optimization of strategies such as zoning and sample selection in automated land cover classification. Therefore, we selected the GlobeLand30-2010, GLC_FCS30-2015, and FROM_GLC2015 global land cover products with a 30-m resolution covering Indonesia, which has a tropical rainforest climate, as a case study, and then analyzed these products in terms of areal consistency, spatial consistency, and accuracy evaluation. The results revealed that (a) all three land cover products revealed that forest is the main land cover type in Indonesia. The area correlation coefficient of any two products is better than 0.89; (b) the areas that are completely consistent among the three products account for 58% of the total area of Indonesia, mainly distributed in the central and northern parts of Kalimantan and Papua, which are dominated by forest land types. The spatial consistency of the three products is low, however, due to the complex surface types and staggered distributions of grassland, shrub, cultivated land, artificial surface, and other land cover types in Java, eastern Sumatra, and the eastern, southern, and northwestern sections of Kalimantan, where the elevation is less than 200 m. Given these results, land cover producers should take heed of the classification accuracy of these areas; (c) the absolute accuracy evaluation demonstrated that the GLC_FCS30-2015 product has the highest overall accuracy (65.59%), followed by the overall accuracy of the GlobeLand30-2010 product (61.65%), while the FROM_GLC2015 exhibits the lowest overall accuracy (57.71%). The mapping accuracy of the three products is higher for forests and artificial surfaces. The cropland mapping accuracy of the GLC_FCS30-2015 product is higher than those of the other two products. The mapping accuracy of all products is low for grassland, shrubland, bareland, and wetland. The classification accuracy of these land cover types requires further improvement and cannot be used directly by land cover users when conducting relevant research in tropical rainforest climate zones, since the utilization of these products could lead to serious errors

Spatial Pattern Consistency among Different Remote-Sensing Land Cover Datasets: A Case Study in Northern Laos

Comparisons of the accuracy and consistency of different remote-sensing land cover datasets are important for the rational application of multi-source land cover datasets to regional development, or to studies of global or local environmental change. Existing comparisons of accuracy or spatial consistency among land cover datasets primarily use confusion or transfer matrices and focus on the type and area consistency of land cover. However, less attention has been paid to the consistency of spatial patterns, and quantitative analyses of spatial pattern consistency are rare. However, when proportions of land cover types are similar, spatial patterns are essential for studies of the ecological functions of a landscape system. In this study, we used classical landscape indices that quantifies spatial patterns to analyze the spatial pattern consistency among different land cover datasets, and chose three datasets (GlobeLand30-2010, FROM-GLC2010, and SERVIR MEKONG2010) in northern Laos as a case study. We also analyzed spatial pattern consistency at different scales after comparing the landscape indices method with the confusion matrix method. We found that the degree of consistency between GlobeLand30-2010 and SERVIR MEKONG2010 was higher than that of GlobeLand30-2010 and FROM-GLC2010, FROM-GLC2010, and SERVIR MEKONG2010 based on the confusion matrix, mainly because of the best forest consistency and then water. However, the spatial consistency results of the landscape indices analysis show that the three datasets have large differences in the number of patches (NP), patch density (PD), and landscape shape index (LSI) at the original scale of 30 m, and decrease with the increase of the scale. Meanwhile, the aggregation index (AI) shows different changes, such as the changing trend of the forest aggregation index increasing with the scale. Our results suggested that, when using or producing land cover datasets, it is necessary not only to ensure the consistency of landscape types and areas, but also to ensure that differences among spatial patterns are minimized, especially those exacerbated by scale. Attention to these factors will avoid larger deviations and even erroneous conclusions from these data products