2-Methyl-1-phenyl-1H-indole-3-carbo­nitrile

In the title compound, C16H12N2, the dihedral angle between the indole ring system and the pendant phenyl ring is 64.92 (5)°. The crystal packing features aromatic π–π stacking [centroid–centroid separation = 3.9504 (9) Å] and C—H⋯π inter­actions

MMP7 expression regulated by endocrine therapy in ERβ-positive colon cancer cells

<p>Abstract</p> <p>Background</p> <p>Many studies have shown that colon cancer is an estrogen-dependent carcinoma. This study explored the efficacy of endocrine therapy in colon cancer cells with high metastatic potential (HT29). We investigated the proliferation of HT29 cells after exposure to endocrine therapy (tamoxifen) and 5-FU.</p> <p>Methods</p> <p>Apoptosis was evaluated using flow cytometry. The expression of matrix metalloproteinases 7 (MMP-7) and estrogen receptor beta (ERβ) was measured by reverse transcription-polymerase chain reaction (RT-PCR) and western blot. The migration capability of treated cells was determined with wound scratch assay.</p> <p>Results</p> <p>Tamoxifen alone, 5-FU alone, and the combination of the two drugs can significantly inhibit HT29 cell proliferation and migration, block the cells in G₂/M phase and induce cell apoptosis. These drugs also can down-regulate MMP7 and ERβ expression.</p> <p>Conclusion</p> <p>Our findings suggest that endocrine therapy is an efficient therapy for inhibiting ERβ-positive colon cancer cell proliferation and migration via down-regulation of MMP7.</p

The effect of early and intensive statin therapy on ventricular premature beat or non-sustained ventricular tachycardia in patients with acute coronary syndrome

Background: Our study&#8217;s aim was to evaluate the prognostic value of early and intensive lipid-lowering treatment on ventricular premature beat or non-sustained ventricular tachycardia (NSVT) after acute coronary syndrome (STEMI, non-STEMI, and unstable angina pectoris). Methods: Some 586 patients with acute coronary syndrome were randomly divided into two groups: Group A (with conventional statin therapy, to receive 10 mg/day atorvastatin, n = 289) and Group B (given early and intensive statin therapy, 60 mg immediately and 40 mg/day atorvastatin, n = 297). The frequency of ventricular premature beat and NSVT was recorded via Holter monitoring after hospitalization (24 h and 72 h). Results: Seventy seven (11.8%) patients had NSVT. When compared to patients with no documented NSVT, patients with NSVT were older and more frequently had myocardial infarction in their history, diabetes mellitus, atrial fibrillation and an ejection fraction < 40%. Ventricular premature beats decreased significantly in the early and aggressive treatment group (24 h, p < 0.01; 72 h, p < 0.001). A significant reduction in NSVT was seen in the early and aggressive treatment group (24 h, p < 0.01; 72 h, p < 0.001). There were no side effects observed in either group. Conclusions: Early and intensive lipid-lowering treatment can clearly decrease ventricular premature beats and NSVT. (Cardiol J 2010; 17, 4: 381-385

1-(2-Chloro­phenyl)-6-fluoro-2-methyl-1H-indole-3-carbonitrile

In the title compound, C16H10ClFN2, the dihedral angle between the indole ring system and the benzyl ring is 80.91 (5)°. The crystal packing features C—H⋯Cl, C—H⋯F and C—H⋯π inter­actions