Separation and Purification of Two Flavone Glucuronides from Erigeron multiradiatus (Lindl.) Benth with Macroporous Resins

Scutellarein-7-O-β-D-glucuronide (SG) and apigenin-7-O-β-D-glucuronide (AG) are two major bioactive constituents with known pharmacological effects in Erigeron multiradiatus. In this study, a simple method for preparative separation of the two flavone glucuronides was established with macroporous resins. The performance and adsorption characteristics of eight macroporous resins including AB-8, HPD100, HPD450, HPD600, D100, D101, D141, and D160 have been evaluated. The results confirmed that D141 resin offered the best adsorption and desorption capacities and the highest desorption ratio for the two glucuronides among the tested resins. Sorption isotherms were constructed for D141 resin under optimal ethanol conditions and fitted well to the Freundlich and Langmuir models (R2 > 0.95). Dynamic adsorption and desorption tests was performed on column packed with D141 resin. After one-run treatment with D141 resin, the two-constituent content in the final product was increased from 2.14% and 1.34% in the crude extract of Erigeron multiradiatus to 24.63% and 18.42% in the final products with the recoveries of 82.5% and 85.4%, respectively. The preparative separation of SG and AG can be easily and effectively achieved via adsorption and desorption on D141 resin, and the method developed can be referenced for large-scale separation and purification of flavone glucuronides from herbal raw materials

A fast two-level Strang splitting method for multi-dimensional spatial fractional Allen-Cahn equations with discrete maximum principle

In this paper, we study the numerical solutions of the multi-dimensional spatial fractional Allen-Cahn equations. After semi-discretization for the spatial fractional Riesz derivative, a system of nonlinear ordinary differential equations with Toeplitz structure is obtained. For the sake of reducing the computational complexity, a two-level Strang splitting method is proposed, where the Toeplitz matrix in the system is split into the sum of a circulant matrix and a skew-circulant matrix. Therefore, the proposed method can be quickly implemented by the fast Fourier transform, substituting to calculate the expensive Toeplitz matrix exponential. Theoretically, the discrete maximum principle of our method is unconditionally preserved. Moreover, the analysis of error in the infinite norm with second-order accuracy is conducted in both time and space. Finally, numerical tests are given to corroborate our theoretical conclusions and the efficiency of the proposed method

ClimateNeRF: Physically-based Neural Rendering for Extreme Climate Synthesis

Physical simulations produce excellent predictions of weather effects. Neural radiance fields produce SOTA scene models. We describe a novel NeRF-editing procedure that can fuse physical simulations with NeRF models of scenes, producing realistic movies of physical phenomena inthose scenes. Our application -- Climate NeRF -- allows people to visualize what climate change outcomes will do to them. ClimateNeRF allows us to render realistic weather effects, including smog, snow, and flood. Results can be controlled with physically meaningful variables like water level. Qualitative and quantitative studies show that our simulated results are significantly more realistic than those from state-of-the-art 2D image editing and 3D NeRF stylization.Comment: project page: https://climatenerf.github.io

Crowd Research at School: Crossing Flows

It has become widely known that when two flows of pedestrians cross stripes emerge spontaneously by which the pedestrians of the two walking directions manage to pass each other in an orderly manner. In this work, we report about the results of an experiment on crossing flows which has been carried out at a German school. These results include that previously reported high flow volumes on the crossing area can be confirmed. The empirical results are furthermore compared to the results of a simulation model which succesfully could be calibrated to catch the specific properties of the population of participants.Comment: contribution to proceedings of Traffic and Granular Flow 2013 held in J\"ulich, German