One Health: The global challenge of epidemic and endemic leishmaniasis

'One Health' proposes the unification of medical and veterinary sciences with the establishment of collaborative ventures in clinical care, surveillance and control of cross-species disease, education, and research into disease pathogenesis, diagnosis, therapy and vaccination. The concept encompasses the human population, domestic animals and wildlife, and the impact that environmental changes ('environmental health') such as global warming will have on these populations. Visceral leishmaniasis is a perfect example of a small companion animal disease for which prevention and control might abolish or decrease the suffering of canine and human patients, and which aligns well with the One Health approach. In this review we discuss how surveillance for leishmaniases is undertaken globally through the control of anthroponootic visceral leishmaniasis (AVL) and zoonotic visceral leishmaniasis (ZVL). The ZVL epidemic has been managed to date by the culling of infected dogs, treatment of human cases and control of the sandfly vector by insecticidal treatment of human homes and the canine reservoir. Recently, preventive vaccination of dogs in Brazil has led to reduction in the incidence of the canine and human disease. Vaccination permits greater dog owner compliance with control measures than a culling programme. Another advance in disease control in Africa is provided by a surveillance programme that combines remote satellite sensing, ecological modelling, vector surveillance and geo-spatial mapping of the distribution of vectors and of the animal-to-animal or animal-to-human pathogen transmission. This coordinated programme generates advisory notices and alerts on emerging infectious disease outbreaks that may impede or avoid the spreading of visceral leishmaniasis to new areas of the planet as a consequence of global warming

Effective dynamics and applications in periodic kicks systems

In this work, we study the kick dynamics of periodically driven quantum systems, and provide a time-independent effective Hamiltonian with the analytical form to reasonably describe the effective dynamics in a long timescale. We find that the effective coupling strength can be much larger than the coupling strength of the original system in some parameter regions, which stems from the zero time duration of kicks. Furthermore, different regimes can be transformed from and to each other in the same three-level system by only modulating the period of periodic kicks. In particular, the population of excited states can be selectively suppressed in periodic kicks, benefiting from the large detuning regime of the original system. Finally, we demonstrate some applications and physical implementation of periodic kicks in quantum systems. Those unique features would make periodic kicks becoming a powerful tool for quantum state manipulations.Comment: 21pages, 9 figure

Composite pulses for high fidelity population transfer in three-level systems

In this work, we propose a composite pulses (CPs) scheme by modulating phases to achieve high fidelity population transfer in three-level systems. To circumvent the obstacle that not enough variables are exploited to eliminate the systematic errors in the transition probability, we put forward a cost function to find the optimal value. The cost function is independently constructed either in ensuring an accurate population of the target state, or in suppressing the population of the leakage state, or both of them. The results demonstrate that population transfer is implemented with high fidelity even when existing the deviations in the coupling coefficients. Furthermore, our CPs scheme can be extensible to arbitrarily long pulse sequences. As an example, we employ the CPs sequence for achieving the three-atom singlet state in an atom-cavity system with ultrahigh fidelity. The final singlet state shows robustness against deviations and is not seriously affected by waveform distortions. Also, the singlet state maintains a high fidelity under the decoherence environment