What Drives Consumers in China to Buy Clothing Online? Application of the Technology Acceptance Model

An enormous number of Internet users have made China a profitable e-commerce marketplace, and clothing is one of the most frequently purchased items. This study explores the predictors of consumers’ motivation to buy clothing online in China by extending the technology acceptance model. Data were collected via an online questionnaire, resulting in 504 returned responses. The results indicate that perceived usefulness has a significant effect on consumers’ intention to buy clothing online; however, no direct relationship between perceived ease of use and buying intention was found. Furthermore, perceived convenience, perceived money saving, and perceived time-saving can explain why consumers perceive buying clothing online as useful, and these perceptions have positive effects on buying intention. Additionally, the findings imply that fashion innovativeness and friend circles significantly influence consumers’ intention to purchase clothing online. This article discusses the results and provides recommendations for implication and future research

A Novel BCC-Structure Zr-Nb-Ti Medium-Entropy Alloys (MEAs) with Excellent Structure and Irradiation Resistance

Medium-entropy alloys (MEAs) are prospective structural materials for emerging advanced nuclear systems because of their outstanding mechanical properties and irradiation resistance. In this study, the microstructure and mechanical properties of three new single-phase body-centered cubic (BCC) structured MEAs (Zr40Nb35Ti25, Zr50Nb35Ti15, and Zr60Nb35Ti5) before and after irradiation were investigated. It is shown that the yield strength and elongation after fracture at room temperature are greater than 900 MPa and 10%, respectively. Three MEAs were irradiated with 3 MeV Fe11+ ions to 8 × 1015 and 2.5 × 1016 ions/cm2 at temperatures of 300 and 500 °C, to investigate the irradiation-induced hardening and microstructure changes. Compared with most conventional alloys, the three MEAs showed only negligible irradiation hardening and even softening in some cases. After irradiation, they exhibit somewhat surprising lattice constant reduction, and the microstructure contains small dislocation loops. Neither cavities nor precipitates were observed. This indicates that the MEAs have better irradiation resistance than traditional alloys, which can be attributed to the high-entropy and lattice distortion effect of MEAs

Assessment of Hydrological Changes and Their Influence on the Aquatic Ecology over the last 58 Years in Ganjiang Basin, China

Runoff is the key driving factor of the Ganjiang River ecosystem. Human activities such as reservoir construction have greatly changed the state of runoff. In order to analyze the influence of Ganjiang Reservoir on the hydrological regime, the following paper is based on the daily precipitation data of 53 rainfall stations in Ganjiang River Basin from 1959 to 2016, and the daily runoff data of three stations in Dongbei, Ji’an, and Waizhou from 1959 to 2016. The Mann–Kendall test (MK) was used to analyze the trend of precipitation and runoff in Ganjiang River Basin. The Sliding t-Test (ST) was used to determine the abrupt change time of runoff in flood season within typical cross-sections of upper, middle, and lower reaches of Ganjiang River Basin, Ji’an, and Waizhou. Indicators of hydrological change (IHA), range of variability approach (RVA), and other methods were used to analyze the changes of 32 hydrological indicators in Ganjiang River Basin. The results showed that (1) The annual and flood season precipitation in Ganjiang River Basin increased from 1992 to 2016, but it did not reach a significant level. The change of annual runoff at Dongbei and Waizhou Stations was the same as that of the annual precipitation in Ganjiang River Basin. The runoff of Dongbei Station in flood season decreased from 1986 to 2016, and the runoff of Waizhou Railway Station in flood season decreased from 2008 to 2016. It showed that precipitation had a great influence on annual runoff, and human activities made the annual runoff distribution process more uniform; (2) The abrupt changes of runoff in flood season at three hydrological stations in Ganjiang River Basin occurred in 1991, and reached a significant level of 0.01; (3) There were five hydrological indicators of Dongbei Station which had reached height change. The change degree of low (l) pulse duration was −92.24%, the change degree of high (h) pulse count was −86.8%, the change degree of flow rise rate was 87.06%, the change degree of fall rate was −92.24%, and the change degree of number of reversals was −100%. Four hydrological indicators of Ji’an Station had reached high change degree, the count and duration of high pulse changes were −73.33% and −73.65%, the change degree of fall rate was −79%, and the change degree of number of reversals was −100%. Waizhou Station did not reach the high change indicator. The hydrological regime of the upper and middle reaches of Ganjiang River has changed greatly, while the hydrological regime of the lower reaches has changed little. The hydrological regime in the upper and middle reaches of Ganjiang River Basin has been highly changed by human activities such as dam construction. The change of hydrological conditions in the upper and middle reaches of Ganjiang River Basin may reduce the area of aquatic organisms’ habitat, be harmful to the spawning, migration, and survival of aquatic organisms, reduce the interception of organic matter in floodplains, and increase the drought pressure of plants. The reservoir ecological operation of rivers with numerous reservoirs should be considered, joint reservoir dispatching schemes should be formulated for the study area so as to maximize the comprehensive benefits. This study provides a reference for water resources management and reservoir operation in Ganjiang River Basin. The next step is to use a habitat model to simulate the habitat of Ganjiang River Basin

Trend Analysis of Temperature and Precipitation Extremes during Winter Wheat Growth Period in the Major Winter Wheat Planting Area of China

In this study, the major winter wheat planting area of China is selected as the study area, with the time scale of the growth period of winter wheat (a total of 56 growth periods during October 1961 to May 2016). The significance, stability, magnitude of the trend and the average trend of the study area with eight temperature indices and seven precipitation indices of 453 meteorological stations are tested by Mann−Kendall method and Sen’s nonparametric method. The following observation can be made: (1) the cold extreme indices show strong and stable downward trend in most of the stations in the study area, while the hot extreme indices show a strong and stable upward trend, especially in the northern winter wheat planting area and the north of the southern winter wheat planting area. (2) The trends of extreme precipitation indices in most of the sites in the study area are insignificant and unstable. Only in R20mm, a significant and stable decreasing trend is shown in some stations, which is mainly located in the northern winter wheat planting area and part of the central and western regions in the study area. The results in some ways could enrich the references for understanding the climate change in the growth period of winter wheat in the region and help to formulate a better agronomic management practice of winter wheat

Construction and validation of a metabolism-associated gene signature for predicting the prognosis, immune landscape, and drug sensitivity in bladder cancer

Abstract Tumor Metabolism is strongly correlated with prognosis. Nevertheless, the prognostic and therapeutic value of metabolic-associated genes in BCa patients has not been fully elucidated. First, in this study, metabolism-related differential expressed genes DEGs with prognostic value in BCa were determined. Through the consensus clustering algorithm, we identified two molecular clusters with significantly different clinicopathological features and survival prognosis. Next, a novel metabolism-related prognostic model was established. Its reliable predictive performance in BCa was verified by multiple external datasets. Multivariate Cox analysis exhibited that risk score were independent prognostic factors. Interestingly, GSEA enrichment analysis of GO, KEGG, and Hallmark gene sets showed that the biological processes and pathways associated with ECM and collagen binding in the high-risk group were significantly enriched. Notely, the model was also significantly correlated with drug sensitivity, immune cell infiltration, and immunotherapy efficacy prediction by the wilcox rank test and chi-square test. Based on the 7 immune infiltration algorithm, we found that Neutrophils, Myeloid dendritic cells, M2 macrophages, Cancer-associated fibroblasts, etc., were more concentrated in the high-risk group. Additionally, in the IMvigor210, GSE111636, GSE176307, or our Truce01 (registration number NCT04730219) cohorts, the expression levels of multiple model genes were significantly correlated with objective responses to anti-PD-1/anti-PD-L1 immunotherapy. Finally, the expression of interested model genes were verified in 10 pairs of BCa tissues and para-carcinoma tissues by the HPA and real-time fluorescent quantitative PCR. Altogether, the signature established and validated by us has high predictive power for the prognosis, immunotherapy responsiveness, and chemotherapy sensitivity of BCa

Pan-cancer analyses of clinical prognosis, immune infiltration, and immunotherapy efficacy for TRPV family using multi-omics data

Background: Transient receptor potential cation channel subfamily V (TRPV) play an essential in cancer initiation, progression, and treatment. TRPV expression alteration are shown relate to multiple cancers prognosis and treatment of cancers but are less-studied in pan-cancer. In this study, we characterize the clinical prediction value of TRPV at pan-cancer level. Methods: Several databases were used to examine the transcript expression difference in tumor vs. normal tissue, copy-number variant (CNV) and single nucleotide polymorphisms (SNP) mutation of each TRPV members in pan-cancer, including The Cancer Genome Atlas (TCGA) and cBioPortal. We performed K-M survival curve and univariate Cox regression analyses to identify survival and prognosis value of TRPV. CellMiner were selected to explore drug sensitivity. We also analyzed association between tumor mutation burden (TMB), microsatellite instability (MSI), tumor immune microenvironment and TRPV family genes expression. Moreover, we investigated the relationship between TRPVs expression and effectiveness of immunotherapy in multiple cohorts, including one melanoma (GSE78220), one renal cell carcinoma (GSE67501), and three bladder cancer cohorts (GSE111636, IMvigor210, GSE176307 and our own sequencing dataset (TRUCE-01)), and further analyzed the changes of TRPVs expression before and after treatment (tislelizumab combined with nab-paclitaxel) of bladder cancer. Next, we made a special effort to investigate and study biological functions of TRPV in bladder cancer using gene set enrichment analysis (GSEA), and conducted immune infiltration analysis with TRPVs family genes expression, copy number or somatic mutations of bladder cancer by TIMER 2.0. Finally, real-time PCR and protein expression validation of TRPVs within 10 paired cancer and para-carcinoma tissue samples, were also performed in bladder cancer. Results: Only TRPV2 expression was lower in most cancer types among TRPV family genes. All TRPVs were correlated with survival changes. Amplification was the significant gene alternation in all TRPVs. Next, analysis between TRPVs and clinical traits showed that TRPVs were related to pathologic stage, TNM stage and first course treatment outcome. Moreover, TRPV expression was highly correlated with MSI and TMB. Immunotherapy is a research hotspot at present, our result showed the significant association between TRPVs expression and immune infiltration indicated that TRPV expression alternation could be used to guide prognosis. In addition, we also discovered that the expression level of TRPV1/2/3/4/6 was positively or negatively correlated with objective responses to anti-PD-1/PD-L1 across multiple immunotherapy cohort. Further analysis of drug sensitivity showed the value to treatment. Based on the above analysis, we next focused on TRPV family in bladder cancer. The result demonstrated TRPV also played an important role in bladder cancer. Finally, qPCR assay verified our analysis in bladder cancer. Conclusion: Our study firstly revealed expression and genome alternation of TRPV in pan-cancer. TRPV could be used to predict prognosis or instructing treatment of human cancers, especially bladder cancer

Genome-Wide Association Study Provides Insight into the Genetic Control of Plant Height in Rapeseed (Brassica napus L.)

Plant height is a key morphological trait of rapeseed. In this study, we measured plant height of a rapeseed population across six environments. This population contains 476 inbred lines representing the major Chinese rapeseed genepool and 44 lines from other countries. The 60K Brassica Infinium® SNP array was utilized to genotype the association panel. A genome-wide association study (GWAS) was performed via three methods, including a robust, novel, nonparametric Anderson-Darling (A-D) test. Consequently, 68 loci were identified as significantly associated with plant height (P 0.1), we found plausible candidates orthologous to the documented Arabidopsis genes involved in height regulation. One significant association found by GWAS colocalized with the established height locus BnRGA in rapeseed. Our results provide insights into the genetic basis of plant height in rapeseed and may facilitate marker-based breeding