Interpretable Subgroup Discovery in Treatment Effect Estimation with Application to Opioid Prescribing Guidelines

The dearth of prescribing guidelines for physicians is one key driver of the current opioid epidemic in the United States. In this work, we analyze medical and pharmaceutical claims data to draw insights on characteristics of patients who are more prone to adverse outcomes after an initial synthetic opioid prescription. Toward this end, we propose a generative model that allows discovery from observational data of subgroups that demonstrate an enhanced or diminished causal effect due to treatment. Our approach models these sub-populations as a mixture distribution, using sparsity to enhance interpretability, while jointly learning nonlinear predictors of the potential outcomes to better adjust for confounding. The approach leads to human-interpretable insights on discovered subgroups, improving the practical utility for decision suppor

Multi-Clue Reasoning with Memory Augmentation for Knowledge-based Visual Question Answering

Visual Question Answering (VQA) has emerged as one of the most challenging tasks in artificial intelligence due to its multi-modal nature. However, most existing VQA methods are incapable of handling Knowledge-based Visual Question Answering (KB-VQA), which requires external knowledge beyond visible contents to answer questions about a given image. To address this issue, we propose a novel framework that endows the model with capabilities of answering more general questions, and achieves a better exploitation of external knowledge through generating Multiple Clues for Reasoning with Memory Neural Networks (MCR-MemNN). Specifically, a well-defined detector is adopted to predict image-question related relation phrases, each of which delivers two complementary clues to retrieve the supporting facts from external knowledge base (KB), which are further encoded into a continuous embedding space using a content-addressable memory. Afterwards, mutual interactions between visual-semantic representation and the supporting facts stored in memory are captured to distill the most relevant information in three modalities (i.e., image, question, and KB). Finally, the optimal answer is predicted by choosing the supporting fact with the highest score. We conduct extensive experiments on two widely-used benchmarks. The experimental results well justify the effectiveness of MCR-MemNN, as well as its superiority over other KB-VQA methods

Cross-Modal Reasoning with Event Correlation for Video Question Answering

Video Question Answering (VideoQA) is a very attractive and challenging research direction aiming to understand complex semantics of heterogeneous data from two domains, i.e., the spatio-temporal video content and the word sequence in question. Although various attention mechanisms have been utilized to manage contextualized representations by modeling intra- and inter-modal relationships of the two modalities, one limitation of the predominant VideoQA methods is the lack of reasoning with event correlation, that is, sensing and analyzing relationships among abundant and informative events contained in the video. In this paper, we introduce the dense caption modality as a new auxiliary and distill event-correlated information from it to infer the correct answer. To this end, we propose a novel end-to-end trainable model, Event-Correlated Graph Neural Networks (EC-GNNs), to perform cross-modal reasoning over information from the three modalities (i.e., caption, video, and question). Besides the exploitation of a brand new modality, we employ cross-modal reasoning modules for explicitly modeling inter-modal relationships and aggregating relevant information across different modalities, and we propose a question-guided self-adaptive multi-modal fusion module to collect the question-oriented and event-correlated evidence through multi-step reasoning. We evaluate our model on two widely-used benchmark datasets and conduct an ablation study to justify the effectiveness of each proposed component

Human Pose Transfer with Augmented Disentangled Feature Consistency

Deep generative models have made great progress in synthesizing images with arbitrary human poses and transferring poses of one person to others. Though many different methods have been proposed to generate images with high visual fidelity, the main challenge remains and comes from two fundamental issues: pose ambiguity and appearance inconsistency. To alleviate the current limitations and improve the quality of the synthesized images, we propose a pose transfer network with augmented Disentangled Feature Consistency (DFC-Net) to facilitate human pose transfer. Given a pair of images containing the source and target person, DFC-Net extracts pose and static information from the source and target respectively, then synthesizes an image of the target person with the desired pose from the source. Moreover, DFC-Net leverages disentangled feature consistency losses in the adversarial training to strengthen the transfer coherence and integrates a keypoint amplifier to enhance the pose feature extraction. With the help of the disentangled feature consistency losses, we further propose a novel data augmentation scheme that introduces unpaired support data with the augmented consistency constraints to improve the generality and robustness of DFC-Net. Extensive experimental results on Mixamo-Pose and EDN-10k have demonstrated DFC-Net achieves state-of-the-art performance on pose transfer.Comment: 22 pages, 6 figure