Estimating Individualized Decision Rules with Tail Controls

With the emergence of precision medicine, estimating optimal individualized decision rules (IDRs) has attracted tremendous attention in many scientific areas. Most existing literature has focused on finding optimal IDRs that can maximize the expected outcome for each individual. Motivated by complex individualized decision making procedures and popular conditional value at risk (CVaR) measures, we propose a new robust criterion to estimate optimal IDRs in order to control the average lower tail of the subjects' outcomes. In addition to improving the individualized expected outcome, our proposed criterion takes risks into consideration, and thus the resulting IDRs can prevent adverse events. The optimal IDR under our criterion can be interpreted as the decision rule that maximizes the ``worst-case" scenario of the individualized outcome when the underlying distribution is perturbed within a constrained set. An efficient non-convex optimization algorithm is proposed with convergence guarantees. We investigate theoretical properties for our estimated optimal IDRs under the proposed criterion such as consistency and finite sample error bounds. Simulation studies and a real data application are used to further demonstrate the robust performance of our method

Effects of ADIPOQ polymorphisms on PCOS risk: a meta-analysis

Abstract Background Whether adiponectin (ADIPOQ) polymorphisms are associated with the risk of polycystic ovary syndrome (PCOS) remain controversial. Therefore, we performed this study to better explore correlations between ADIPOQ polymorphisms and PCOS risk. Methods Literature retrieve was conducted in PubMed, Medline and Embase. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results Eighteen studies were enrolled for analyses. Pooled overall analyses showed that rs1501299 polymorphism was significantly associated with PCOS risk (recessive model: p = 0.02, OR = 0.77, 95%CI 0.62–0.95; allele model: p = 0.001, OR = 1.15, 95%CI 1.06–1.26). Further subgroup analyses according to ethnicity of participants revealed that rs1501299 and rs2241766 polymorphisms were both significantly correlated with PCOS risk in Caucasians. In addition, rs1501299 polymorphism was also significantly correlated with PCOS risk in East Asians. Conclusions Our findings indicated that rs1501299 and rs2241766 polymorphisms might serve as genetic biomarkers of PCOS in certain ethnicities

Wind resistance aerial path planning for efficient reconstruction of offshore ship

When the unmanned aerial vehicle (UAV) is applied to three-dimensional (3D) reconstruction of the offshore ship, it faces two problems: the battery capacity limitation of the UAV and the disturbance of the wind in the environment. Wind disturbance is generally not considered in the path planning process of the existing UAV 3D reconstruction path planning research. Therefore, the planned path is only suitable for no-wind or light-wind scenarios. For the 3D reconstruction of ship targets, we propose a UAV path planning method that can satisfy both reconstruction efficiency and wind disturbance resistance requirements. Firstly, the concept of model surface complexity is proposed to generate a more efficient candidate view set. Secondly, the Min–Max strategy and a new viewpoint construction method are used to generate the initial path. Thirdly, combined with the wind field model, a method for generating a stable path against wind disturbance based on the idea of interval optimization is proposed. Experimental results demonstrate that our method can adaptively determine the number of sample points and viewpoints according to ship’s geometric characteristics and further reduce the number of viewpoints without significantly affecting the reconstruction quality; the path planned by our method is also stable against wind disturbance