2,398 research outputs found
A controllable superconducting electromechanical oscillator with a suspended membrane
We fabricate a microscale electromechanical system, in which a suspended
superconducting membrane, treated as a mechanical oscillator, capacitively
couples to a superconducting microwave resonator. As the microwave driving
power increases, nonmonotonic dependence of the resonance frequency of the
mechanical oscillator on the driving power has been observed. We also
demonstrate the optical switching of the resonance frequency of the mechanical
oscillator. Theoretical models for qualitative understanding of our
experimental observations are presented. Our experiment may pave the way for
the application of a mechanical oscillator with its resonance frequency
controlled by the electromagnetic and/or optical fields, such as a
microwave-optical interface and a controllable element in a
superqubit-mechanical oscillator hybrid system.Comment: 8 pages,4 figure
Targeted Deletion of the Murine Lgr4 Gene Decreases Lens Epithelial Cell Resistance to Oxidative Stress and Induces Age-Related Cataract Formation
Oxidative stress contributes to the formation of cataracts. The leucine rich repeat containing G protein-coupled receptor 4 (LGR4, also known as GPR48), is important in many developmental processes. Since deletion of Lgr4 has previously been shown to lead to cataract formation in mice, we sought to determine the specific role that Lgr4 plays in the formation of cataracts. Initially, the lens opacities of Lgr4−/− mice at different ages without ocular anterior segment dysgenesis (ASD) were evaluated with slit-lamp biomicroscopy. Lenses from both Lgr4−/− and wild-type mice were subjected to oxidation induced protein denaturation to assess the ability of the lens to withstand oxidation. The expression of antioxidant enzymes was evaluated with real-time quantitative PCR. Phenotypically, Lgr4−/− mice showed earlier onset of lens opacification and higher incidence of cataract formation compared with wild-type mice of similar age. In addition, Lgr4−/− mice demonstrated increased sensitivity to environmental oxidative damage, as evidenced by altered protein expression. Real-time quantitative PCR showed that two prominent antioxidant defense enzymes, catalase (CAT) and superoxidase dismutase-1 (SOD1), were significantly decreased in the lens epithelial cells of Lgr4−/− mice. Our results suggest that the deletion of Lgr4 can lead to premature cataract formation, as well as progressive deterioration with aging. Oxidative stress and altered expression of several antioxidant defense enzymes contribute to the formation of cataracts
Laparoscopic-assisted total gastrectomy with D2 lymph node dissection: a case of 12-year-old child with advanced gastric cancer
The video shows the operation of laparoscopic-assisted total gastrectomy with D2 lymph node dissection for a 12-year-old child with advanced gastric cancer
SeqGPT: An Out-of-the-box Large Language Model for Open Domain Sequence Understanding
Large language models (LLMs) have shown impressive ability for open-domain
NLP tasks. However, LLMs are sometimes too footloose for natural language
understanding (NLU) tasks which always have restricted output and input format.
Their performances on NLU tasks are highly related to prompts or demonstrations
and are shown to be poor at performing several representative NLU tasks, such
as event extraction and entity typing. To this end, we present SeqGPT, a
bilingual (i.e., English and Chinese) open-source autoregressive model
specially enhanced for open-domain natural language understanding. We express
all NLU tasks with two atomic tasks, which define fixed instructions to
restrict the input and output format but still ``open'' for arbitrarily varied
label sets. The model is first instruction-tuned with extremely fine-grained
labeled data synthesized by ChatGPT and then further fine-tuned by 233
different atomic tasks from 152 datasets across various domains. The
experimental results show that SeqGPT has decent classification and extraction
ability, and is capable of performing language understanding tasks on unseen
domains. We also conduct empirical studies on the scaling of data and model
size as well as on the transfer across tasks. Our model is accessible at
https://github.com/Alibaba-NLP/SeqGPT.Comment: Initial version of SeqGP
Fibulin-5 inhibits hepatocellular carcinoma cell migration and invasion by down-regulating matrix metalloproteinase-7 expression
Analysis of the efficacy and safety of inpatient and outpatient initiation of KD for the treatment of pediatric refractory epilepsy using generalized estimating equations
ObjectiveTo compare the efficacy and safety of inpatient and outpatient initiation ketogenic diet (KD) protocol of pediatric refractory epilepsy.MethodsEligible children with refractory epilepsy were randomly assigned to receive KD with inpatient and outpatient initiation. The generalized estimation equation (GEE) model was used to analyze the longitudinal variables of seizure reduction, ketone body, weight, height, body mass index (BMI), and BMI Z-score at different follow-up times between the two groups.ResultsBetween January 2013 and December 2021, 78 and 112 patients were assigned to outpatient and inpatient KD initiation groups, respectively. There were no statistical differences between the two groups based on baseline demographics and clinical characteristics (all Ps > 0.05). The GEE model indicated that the rate of reduction of seizures≥50% in the outpatient initiation group was higher than that of the inpatient initiation group (p = 0.049). A negative correlation was observed between the seizure reduction and blood ketone body at 1, 6, and 12 months (all Ps < 0.05). There were no significant differences in height, weight, BMI, and BMI Z-score between the two groups over the 12-month period by the GEE models (all Ps > 0.05). Adverse events were reported by 31 patients (43.05%) in the outpatient KD initiation group and 46 patients (42.20%) in the inpatient KD initiation group, but these differences were not statistically significant (p = 0.909).ConclusionOur study shows that outpatient KD initiation is a safe and effective treatment for children with refractory epilepsy
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