Study on Dynamic Mechanical Properties of Limestone under Uniaxial Impact Compressive Loads

The dynamic mechanical properties of limestone are studied with 5 types of impact pressure acting on limestone samples in axial direction in this paper. The rubber shaper with a diameter of 5 mm and thickness of 2 mm is adopted. Besides the conical punch of split pressure bar of Hopkinson with a diameter of 50 mm is also used. The half-sinusoid pulse is obtained by using the pulse shaper method and special punch method; the constant strain rate deformation of the sample is realized. Dynamic compressive properties and failure modes of limestone under different impact pressure are investigated. In addition, energy dissipation is studied in the process of experiment. The results show that the dynamic compressive strength of limestone has an exponent relation to strain rate. The failure strain, degree of fragmentation, incident energy, and absorption energy increase, while the energy absorbency decreases with the increasing of strain rate. However, the initial elastic modulus is not sensitive to the strain rate. The research method and conclusions have reference value for the dynamic mechanical properties of other brittle materials

Neuroprotective Effect of Gui Zhi ( Ramulus Cinnamomi

Herb Ephedra (Ma Huang in Chinese) and Ramulus Cinnamomi (Gui Zhi in Chinese) are traditional Chinese herbs, often used together to treat asthma, nose and lung congestion, and fever with anhidrosis. Due to the adverse effects of ephedrine, clinical use of Ma Huang is restricted. However, Gui Zhi extract has been reported to decrease spontaneous activity in rats and exert anti-inflammatory and neuroprotective effects. The present study explored the possible inhibitory effect of Gui Zhi on Ma Huang-induced neurotoxicity in rats when the two herbs were used in combination. All Ma Huang and Ma Huang-Gui Zhi herb pair extracts were prepared using methods of traditional Chinese medicine and were normalized based on the ephedrine content. Two-month-old male Sprague-Dawley rats (n=6 rats/group) were administered Ma Huang or the Ma Huang-Gui Zhi herb pair extracts for 7 days (ephedrine = 48 mg/kg), and locomotor activity was measured. After 7 days, oxidative damage in the prefrontal cortex was measured. Gui Zhi decreased hyperactivity and sensitization produced by repeated Ma Huang administration and attenuated oxidative stress induced by Ma Huang. The results of this study demonstrate the neuroprotective potential of Gui Zhi in Ma Huang-induced hyperactivity and oxidative damage in the prefrontal cortex of rats when used in combination

Metabolomics Analysis of L-Arginine Induced Gastrointestinal Motility Disorder in Rats Using UPLC-MS After Magnolol Treatment

Background and Purpose: Magnolol, as the main active ingredient of Traditional Chinese Medicine, can significantly improve gastrointestinal motility disorders (GMD). In the present study, metabolomics was used to investigate the mechanism of magnolol improving L-arginine induced GMD in rats.Experimental Approach: SD rats were randomly divided into control group, model group and magnolol treated group. L-arginine was injected intraperitoneally in model and magnolol groups to induce GMD model. All intervention regimens were administered by oral gavage, once a day for five consecutive days. Relative gastric emptying rate and propulsive intestinal rate were measured. Metabolites in serum were analyzed based on UPLC-MS metabolomics technique.Results: Magnolol significantly promoted gastric emptying and small intestinal propulsion. Compared with the model group, the level of serotonin and L-tryptophan significantly reversed (P < 0.05) and 22 metabolites reversed in the magnolol group. According to MetPA database analysis, magnolol has mainly affected 10 major metabolic pathways which were related to each other, Tryptophan metabolism is the most critical metabolic pathway associated with gastrointestinal tract.Conclusion: These findings suggest that magnolol has a significantly promoting effect on L-arginine induced gastrointestinal motility disorder in rats, the mechanism is to reduce the production of nitric oxide to weaken the function of nitric oxide relaxing the gastrointestinal smooth muscle and increase the content of serotonin to promote gastrointestinal peristalsis and motility, secretion, absorption of nutrients

Manipulation of Giant Multipole Resonances via Vortex γ\gamma Photons

Traditional photonuclear reactions primarily excite giant dipole resonances, making the measurement of isovector giant resonances with higher multipolarties a great challenge. In this work, the manipulation of collective excitations of different multipole transitions in nuclei via vortex $\gamma$ photons has been investigated. We develop the calculation method for photonuclear cross sections induced by the vortex $\gamma$ photon beam using the fully self-consistent random-phase approximation plus particle-vibration coupling (RPA+PVC) model based on Skyrme density functional. We find that the electromagnetic transitions with multipolarity $J< m_\gamma$ are forbidden for vortex $\gamma$ photons due to the angular momentum conservation, with $m_\gamma$ being the projection of total angular momentum of $\gamma$ photon on its propagation direction. For instance, this allows for probing the isovector giant quadrupole resonance without interference from dipole transitions using vortex $\gamma$ photons with $m_\gamma=2$. The electromagnetic transitions with $J>m_\gamma$ are strongly suppressed compared with the plane-wave-$\gamma$-photon case, and even vanish at specific polar angles. Therefore, the giant resonances with specific multipolarity can be extracted via vortex $\gamma$ photons. Moreover, the vortex properties of $\gamma$ photons can be meticulously diagnosed by measuring the nuclear photon-absorption cross section. Our method opens new avenues for photonuclear excitations, generation of coherent $\gamma$ photon laser and precise detection of vortex particles, and consequently, has significant impact on nuclear physics, nuclear astrophysics and strong laser physics