2 research outputs found
Cytotoxic flavonoids from the young twigs and leaves of Caesalpinia bonduc (Linn) Roxb
The extraction, fractionation and recognition of flavonoids from the ethanolic extract of young twigs and
leaves of C. bonduc were carried out. In addition, cytotoxic study of the flavonoids on two cancer cell lines, BGC-823
and HeLa was carried our using sulphorhodamine B assay. Seven flavonoids, six of which are being reported for the first
time in this plant, were isolated. Their structures were identified by MS and NMR spectroscopic methods. Petroleum
ether, ethyl acetate and water fractions exhibited moderate cytotoxic activity against HeLa cells. Five compounds
showed cytotoxic activity against HeLa cell in comparison with Paclitaxel, while only one compound showed a good
degree of cytotoxic activity against BGC-823 cell in comparison to Paclitaxel. The results obtained showed a structure -
activity relationship