Topological Gauge Structure and Phase Diagram for Weakly Doped Antiferromagnets

We show that the topological gauge structure in the phase string theory of the {\rm t-J} model gives rise to a global phase diagram of antiferromagnetic (AF) and superconducting (SC) phases in a weakly doped regime. Dual confinement and deconfinement of holons and spinons play essential roles here, with a quantum critical point at a doping concentration $x_c\simeq 0.043$. The complex experimental phase diagram at low doping is well described within such a framework.Comment: 4 pages, 2 figures, modified version, to appear in Phys. Rev. Let

Quantum electrodynamics in a whispering-gallery microcavity coated with a polymer nanolayer

Quasi-transverse-electric and -transverse-magnetic fundamental whispering gallery modes in a polymer-coated silica microtoroid are theoretically investigated and demonstrated to possess very high-quality factors. The existence of a nanometer-thickness layer not only evidently reduces the cavity mode volume but also draws the maximal electric field's position of the mode to the outside of the silica toroid, where single quantum dots or nanocrystals are located. Both effects result in a strongly enhanced coherent interaction between a single dipole (for example, a single defect center in a diamond crystal) and the quantized cavity mode. Since the coated microtoroid is highly feasible and robust in experiments, it may offer an excellent platform to study strong-coupling cavity quantum electrodynamics, quantum information, and quantum computation

Mutual-Chern-Simons effective theory of doped antiferromagnets

A mutual-Chern-Simons Lagrangian is derived as a minimal field theory description of the phase-string model for doped antiferromagnets. Such an effective Lagrangian is shown to retain the full symmetries of parity, time-reversal, and global SU(2) spin rotation, in contrast to conventional Chern-Simons theories where first two symmetries are usually broken. Two ordered phases, i.e., antiferromagnetic and superconducting states, are found at low temperatures as characterized by dual Meissner effects and dual flux quantization conditions due to the mutual-Chern-Simons gauge structure. A dual confinement in charge/spin degrees of freedom occurs such that no true spin-charge separation is present in these ordered phases, but the spin-charge separation/deconfinement serves as a driving force in the unconventional phase transitions of these ordered states to disordered states.Comment: 16 pages, 2 figures; published versio

Parkinson\u27s disease-related spatial covariance pattern identified with resting-state functional MRI

In this study, we sought to identify a disease-related spatial covariance pattern of spontaneous neural activity in Parkinson\u27s disease using resting-state functional magnetic resonance imaging (MRI). Time-series data were acquired in 58 patients with early to moderate stage Parkinson\u27s disease and 54 healthy controls, and analyzed by Scaled Subprofile Model Principal Component Analysis toolbox. A split-sample analysis was also performed in a derivation sample of 28 patients and 28 control subjects and validated in a prospective testing sample of 30 patients and 26 control subjects. The topographic pattern of neural activity in Parkinson\u27s disease was characterized by decreased activity in the striatum, supplementary motor area, middle frontal gyrus, and occipital cortex, and increased activity in the thalamus, cerebellum, precuneus, superior parietal lobule, and temporal cortex. Pattern expression was elevated in the patients compared with the controls, with a high accuracy (90%) to discriminate the patients from the controls. The split-sample analysis produced a similar pattern but with a lower accuracy for group discrimination in both the derivation (80%) and the validation (73%) samples. Our results showed that resting-state functional MRI can be potentially useful for identification of Parkinson\u27s disease-related spatial covariance patterns, and for differentiation of Parkinson\u27s disease patients from healthy controls at an individual level.Journal of Cerebral Blood Flow & Metabolism advance online publication, 3 June 2015; doi:10.1038/jcbfm.2015.118

Quantum Phase Diffusion in a Small Underdamped Josephson Junction

Quantum phase diffusion in a small underdamped Nb/AlO$_x$/Nb junction ($\sim$ 0.4 $\mu$m$^2$) is demonstrated in a wide temperature range of 25-140 mK where macroscopic quantum tunneling (MQT) is the dominant escape mechanism. We propose a two-step transition model to describe the switching process in which the escape rate out of the potential well and the transition rate from phase diffusion to the running state are considered. The transition rate extracted from the experimental switching current distribution follows the predicted Arrhenius law in the thermal regime but is greatly enhanced when MQT becomes dominant.Comment: 4 pages, 4 figures, 1 tabl

ZB716, a Steroidal Selective Estrogen Receptor Degrader (SERD), is Orally Efficacious in Blocking Tumor Growth in Mouse Xenograft Models.

Advances in oral SERDs development so far have been confined to nonsteroidal molecules such as those containing a cinnamic acid moiety, which are in earlystage clinical evaluation. ZB716 was previously reported as an orally bioavailable SERD structurally analogous to fulvestrant. In this study, we examined the binding details of ZB716 to the estrogen receptor alpha (ERα) by computer modeling to reveal its interactions with the ligand binding domain as a steroidal molecule. We also found that ZB716 modulates ERα-coregulator interactions in nearly identical manner to fulvestrant. The ability of ZB716 to inhibit cell growth and downregulate ER expression in endocrine resistant, ERα mutant breast cancer cells was demonstrated. Moreover, in both the MCF-7 xenograft and a patient derived xenograft model, orally administered ZB716 showed superior efficacy in blocking tumor growth when compared to fulvestrant. Importantly, such enhanced efficacy of ZB716 was shown to be attributable to its markedly higher bioavailability, as evidenced in the final plasma and tumor tissue concentrations of ZB716 in mice where drug concentrations were found significantly higher than in the fulvestrant treatment group

ITCH Nuclear Translocation and H1.2 Polyubiquitination Negatively Regulate the DNA Damage Response

The downregulation of the DNA damage response (DDR) enables aggressive tumors to achieve uncontrolled proliferation against replication stress, but the mechanisms underlying this process in tumors are relatively complex. Here, we demonstrate a mechanism through which a distinct E3 ubiquitin ligase, ITCH, modulates DDR machinery in triple-negative breast cancer (TNBC). We found that expression of a nuclear form of ITCH was significantly increased in human TNBC cell lines and tumor specimens. Phosphorylation of ITCH at Ser257 by AKT led to the nuclear localization of ITCH and ubiquitination of H1.2. The ITCH-mediated polyubiquitination of H1.2 suppressed RNF8/RNF168-dependent formation of 53BP1 foci, which plays important roles in DDR. Consistent with these findings, impaired ITCH nuclear translocation and H1.2 polyubiquitination sensitized cells to replication stress and limited cell growth and migration. AKT activation of ITCH-H1.2 axis may confer TNBC cells with a DDR repression to counteract the replication stress and increase cancer cell survivorship and growth potential

Distributed phase-covariant cloning with atomic ensembles via quantum Zeno dynamics

We propose an interesting scheme for distributed orbital state quantum cloning with atomic ensembles based on the quantum Zeno dynamics. These atomic ensembles which consist of identical three-level atoms are trapped in distant cavities connected by a single-mode integrated optical star coupler. These qubits can be manipulated through appropriate modulation of the coupling constants between atomic ensemble and classical field, and the cavity decay can be largely suppressed as the number of atoms in the ensemble qubits increases. The fidelity of each cloned qubit can be obtained with analytic result. The present scheme provides a new way to construct the quantum communication network.Comment: 5 pages, 4 figure

Research on Fault Detection and Diagnosis of Scrolling Chiller with ANN

At first the basic research about FDD is summarized, and a detection model based on ANN is initially set up. The paper presents experiments that simulate seven faults, including change flow rate of chilled water, cooling water and refrigerant, charge non-condense gas, shift temperature of cooling water and alter outside cold load. A set of characteristic parameters are defined in order to differentiate these faults and clarify the reasons. Finally, an FDD tool is programmed based on ANN with experimental results which form a training stylebook and test stylebook