Analysis of Demographic Characteristics and Psychological Factors of Opioid Addicts in Zhengzhou Area

Objective: To explore the demographic characteristics and psychological factors of patients with opioid addiction. Methods: A random number method was used to select 200 opioid-addicted patients admitted to the 7th People’s Hospital of Zhengzhou from January 2019 to February 2020. Demographic characteristics and psychosocial factors were analyzed. Result: The proportion of opioid addicts aged 21 ~ 30 was the highest; the proportion of men was significantly higher; the proportion of people who is between jobs/unemployed is the highest; the proportion of junior middle school was the highest, and the proportion of unmarried was relatively high; the proportion of opioid addicts with ignorance/curiosity for the cause of first addiction was the highest; the use of suction is snorting, accounting for the highest proportion. According to the analysis of relevant social and psychological factors, the proportion of single parent family group is the highest, the proportion of parent tension is the highest, and the proportion of bad life coping style is relatively high. At the same time, dependent psychology occupies the highest proportion in psychological factors of relapse patients. Conclusion: By analyzing the demographic characteristics of opioid addicts and the psychosocial factors of their addiction, we can strengthen prevention and management for specific groups to reduce the new addition and relapse of opioid addicts

The Therapeutic and Pathogenic Role of Autophagy in Autoimmune Diseases

Autophagy is a complicated cellular mechanism that maintains cellular and tissue homeostasis and integrity via degradation of senescent, defective subcellular organelles, infectious agents, and misfolded proteins. Accumulating evidence has shown that autophagy is involved in numerous immune processes, such as removal of intracellular bacteria, cytokine production, autoantigen presentation, and survival of lymphocytes, indicating an apparent and important role in innate and adaptive immune responses. Indeed, in genome-wide association studies, autophagy-related gene polymorphisms have been suggested to be associated with the pathogenesis of several autoimmune and inflammatory disorders, such as systemic lupus erythematosus, psoriasis, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. In addition, conditional knockdown of autophagy-related genes in mice displayed therapeutic effects on several autoimmune disease models by reducing levels of inflammatory cytokines and autoreactive immune cells. However, the inhibition of autophagy accelerates the progress of some inflammatory and autoimmune diseases via promotion of inflammatory cytokine production. Therefore, this review will summarize the current knowledge of autophagy in immune regulation and discuss the therapeutic and pathogenic role of autophagy in autoimmune diseases to broaden our understanding of the etiopathogenesis of autoimmune diseases and shed light on autophagy-mediated therapies

Molecular Control of Follicular Helper T cell Development and Differentiation

Follicular helper T cells (Tfh) are specialized helper T cells that are predominantly located in germinal centers and provide help to B cells. The development and differentiation of Tfh cells has been shown to be regulated by transcription factors, such as B-cell lymphoma 6 protein (Bcl-6), signal transducer and activator of transcription 3 (STAT3) and B lymphocyte-induced maturation protein-1 (Blimp-1). In addition, cytokines, including IL-21, have been found to be important for Tfh cell development. Moreover, several epigenetic modifications have also been reported to be involved in the determination of Tfh cell fate. The regulatory network is complicated, and the number of novel molecules demonstrated to control the fate of Tfh cells is increasing. Therefore, this review aims to summarize the current knowledge regarding the molecular regulation of Tfh cell development and differentiation at the protein level and at the epigenetic level to elucidate Tfh cell biology and provide potential targets for clinical interventions in the future

Experimental Study of Multispectral Characteristics of an Unmanned Aerial Vehicle at Different Observation Angles

This study investigates multispectral characteristics of an unmanned aerial vehicle (UAV) at different observation angles by experiment. The UAV and its engine are tested on the ground in the cruise state. Spectral radiation intensities at different observation angles are obtained in the infrared band of 0.9–15 μm by a spectral radiometer. Meanwhile, infrared images are captured separately by long-wavelength infrared (LWIR), mid-wavelength infrared (MWIR), and short-wavelength infrared (SWIR) cameras. Additionally, orientation maps of the radiation area and radiance are obtained. The results suggest that the spectral radiation intensity of the UAV is determined by its exhaust plume and that the main infrared emission bands occur at 2.7 μm and 4.3 μm. At observation angles in the range of 0°–90°, the radiation area of the UAV in MWIR band is greatest; however, at angles greater than 90°, the radiation area in the SWIR band is greatest. In addition, the radiance of the UAV at an angle of 0° is strongest. These conclusions can guide IR stealth technique development for UAVs

Power consumption characteristics of cement industry and parameter analysis of self provided power plant

Cement production is an industry that consumes a lot of electric energy. During the period of power shortage in China, the government encouraged multi-channel financing to run electricity to alleviate the power shortage problem of large industrial users. Therefore, many cement enterprises have established their own power plants. This paper analyses the basic electrical characteristics of the cement industry, classifies the loads of enterprises, and studies the regulation characteristics of various types of equipment

Research on Full-Field Dynamic Deflection Measurement of Beams Based on Dense Feature Matching and Mismatch Removal Method

To solve the problems of measurement errors led by mismatches of dense feature matching in machine vision structural deflection measurement, this paper proposes a dense feature extraction, matching, and dual-step mismatch-removal-based full-field structural dynamic deflection measurement method. First, the of dense feature detection and matching theory is introduced to extract the SIFT feature points on a structural surface in an image sequence and matched by FLANN to trace the structure movement, and the mechanisms and causes of mismatches are analyzed. Then, a dual-step mismatch removal method combining RANSAC and Structural Displacement Continuity Restriction (SDCR) is introduced to achieve full-field dynamic beam deflection measurement. The proposed method is validated through indoor cantilever beam experiments, and results show that the method can effectively eliminate a large number of SIFT feature mismatches (accounting for approximately 55% of the total matched feature points). The full-field dynamic displacement field of the beam can be measured with the correctly matched dense feature points by converting dense feature point displacements into continuous and uniform spatiotemporal deflections of the structure. A comparison with the GOM Correlate Professional DIC measurement system was conducted, and the maximum measurement error of the cantilever beam dynamic displacement of the proposed method is between 0.024 and 0.053 mm, the root mean squared error of displacement is approximately 0.01 mm, and the correlation coefficient between two deflection–time curves reaches 0.9964. The proposed algorithm is proven to be effective in full-field displacement measurement and has great potential in future structural health monitoring of bridges

On the Importance of Self owned Power Plants Participating in the Adjustment of Supply and Demand of Power Network under the Reform of Power System

Centralized power generation by self owned power plants of high energy consumption enterprises will lead to insufficient peak shaving capacity of the power grid. Once the self owned power plants have operational problems, they will easily lead to large-scale blackouts, which will have a great impact on power supply reliability. The national electric power system reform opinion points out that the regulation focus of ensuring the balance of power supply and demand in the power grid should be shifted from the generation side to the load side, and the potential advantages of self owned power plants that combine power generation resources with large loads can be utilized. Self owned power plants participate in the equal management and fair competition of public power plants, can better play its role while improving the supervision of self owned power plants, which is conducive to maintaining the order of the power market and improving the stability of the implementation of power reform

Experimental Study of Multispectral Characteristics of an Unmanned Aerial Vehicle at Different Observation Angles

This study investigates multispectral characteristics of an unmanned aerial vehicle (UAV) at different observation angles by experiment. The UAV and its engine are tested on the ground in the cruise state. Spectral radiation intensities at different observation angles are obtained in the infrared band of 0.9–15 μm by a spectral radiometer. Meanwhile, infrared images are captured separately by long-wavelength infrared (LWIR), mid-wavelength infrared (MWIR), and short-wavelength infrared (SWIR) cameras. Additionally, orientation maps of the radiation area and radiance are obtained. The results suggest that the spectral radiation intensity of the UAV is determined by its exhaust plume and that the main infrared emission bands occur at 2.7 μm and 4.3 μm. At observation angles in the range of 0°–90°, the radiation area of the UAV in MWIR band is greatest; however, at angles greater than 90°, the radiation area in the SWIR band is greatest. In addition, the radiance of the UAV at an angle of 0° is strongest. These conclusions can guide IR stealth technique development for UAVs