DHNet: A Distributed Network Architecture for Smart Home

With the increasing popularity of smart homes, more and more devices need to connect to home networks. Traditional home networks mainly rely on centralized networking, where an excessive number of devices in the centralized topology can increase the pressure on the central router, potentially leading to decreased network performance metrics such as communication latency. To address the latency performance issues brought about by centralized networks, this paper proposes a new network system called DHNet, and designs an algorithm for clustering networking and communication based on vector routing. Communication within clusters in a simulated virtual environment achieves a latency of approximately 0.7 milliseconds. Furthermore, by directly using the first non-"lo" network card address of a device as the protocol's network layer address, the protocol avoids the several tens of milliseconds of access latency caused by DHCP. The integration of service discovery functionality into the network layer protocol is achieved through a combination of "server-initiated service push" and "client request + server reply" methods. Compared to traditional application-layer DNS passive service discovery, the average latency is reduced by over 50%. The PVH protocol is implemented in the user space using the Go programming language, with implementation details drawn from Google's gVisor project. The code has been ported from x86\_64 Linux computers to devices such as OpenWrt routers and Android smartphones. The PVH protocol can communicate through "tunnels" to provide IP compatibility, allowing existing applications based on TCP/IP to communicate using the PVH protocol without requiring modifications to their code

Innermost Echoes: Integrating Real-Time Physiology into Live Music Performances

In this paper, we propose a method for utilizing musical artifacts and physiological data as a means for creating a new form of live music experience that is rooted in the physiology of the perform- ers and audience members. By utilizing physiological data (namely Electrodermal Activity (EDA) and Heart Rate Variability (HRV)) and applying this data to musical artifacts including a robotic koto (a traditional 13-string Japanese instrument fitted with solenoids and linear actuators), a Eurorack synthesizer, and Max/MSP software, we aim to develop a new form of semi-improvisational and signif- icantly indeterminate performance practice. It has since evolved into a multi-modal methodology which honors improvisational performance practices and utilizes physiological data which of- fers both performers and audiences an ever-changing and intimate experience. In our first exploratory phase, we focused on the development of a means for controlling a bespoke robotic koto in conjunction with a Eurorack synthesizer system and Max/MSP software for controlling the incoming data. We integrated a reliance on physiological data to infuse a more directly human elements into this artifact system. This allows a significant portion of the decision-making to be directly controlled by the incoming physiological data in real-time, thereby affording a sense of performativity within this non-living system. Our aim is to continue the development of this method to strike a novel balance between intentionality and impromptu performative results

Phantom Undulations: Remote Physiological Sensing in Abstract Installation Works

Phantom Undulations is a mixed-media work in which an artist’s physiological data is being used remotely to manipulate the sounds and visuals of an abstract artifact in a gallery setting. This work relies heavily on the concept of showing the artist’s presence or liveness in an abstract and remote manner through changes in the harmony, rhythm, and timbre of a loosely structured soundscape as well as the physical appearance of the artifact. We propose a method of utilizing real time physiological sensing data through a custom built sensing wristband and accompanying software. This system reads the physiological data of the artist and sends it to the Internet, where it can be received by the artifact anywhere on Earth. In addition to the artist’s physiological data, we also offer a way for the audience to incorporate their own data into the work via several sensing wristbands which will accompany the artifact. Through this collaborative process, we wish to invite the audience to join the artist in manipulating the sonic and visual characteristics of this artifact and create a contrapuntally fluid and responsive musical experience

Altered intestinal microbiota enhances adenoid hypertrophy by disrupting the immune balance

IntroductionAdenoid hypertrophy (AH) is a common upper respiratory disorder in children. Disturbances of gut microbiota have been implicated in AH. However, the interplay of alteration of gut microbiome and enlarged adenoids remains elusive.Methods119 AH children and 100 healthy controls were recruited, and microbiome profiling of fecal samples in participants was performed using 16S rRNA gene sequencing. Fecal microbiome transplantation (FMT) was conducted to verify the effects of gut microbiota on immune response in mice.ResultsIn AH individuals, only a slight decrease of diversity in bacterial community was found, while significant changes of microbial composition were observed between these two groups. Compared with HCs, decreased abundances of Akkermansia, Oscillospiraceae and Eubacterium coprostanoligenes genera and increased abundances of Bacteroides, Faecalibacterium, Ruminococcus gnavus genera were revealed in AH patients. The abundance of Bacteroides remained stable with age in AH children. Notably, a microbial marker panel of 8 OTUs were identified, which discriminated AH from HC individuals with an area under the curve (AUC) of 0.9851 in the discovery set, and verified in the geographically different validation set, achieving an AUC of 0.9782. Furthermore, transfer of mice with fecal microbiota from AH patients dramatically reduced the proportion of Treg subsets within peripheral blood and nasal-associated lymphoid tissue (NALT) and promoted the expansion of Th2 cells in NALT.ConclusionThese findings highlight the effect of the altered gut microbiota in the AH pathogenesis

Explaining the rise of 'human rights' in analyses of Sino-African relations

Popular perceptions of China and its global role are often shaped by two words: 'made in'. Yet this vision of China that focuses primarily on Beijing as a coming economic superpower is relatively new, and it is not that long ago that two other words tended to dominate debates on and discourses of China: 'human rights'. To be sure, real interest in human rights in China was never the only issue in other states' relations with China, nor consistently pursued throughout the years (Nathan, 1994). Nor did human rights totally subsequently disappear from the political agenda.1 Nevertheless, the rhetorical importance of human rights - perhaps best epitomised by the narrow defeat of resolutions condemning Chinese policy in 1995 at the Human Rights Council in Geneva - stands in stark contrast to the relative silence thereafter as the bottom line of most states' relations with Beijing took on ever greater economic dimensions

Frisson Waves: Exploring Automatic Detection, Triggering and Sharing of Aesthetic Chills in Music Performances

Frisson is the feeling and experience of physical reactions such as shivers, tingling skin, and goosebumps. Using entrainment through facilitating interpersonal transmissions of embodied sensations, we present "Frisson Waves" with the aim to enhance live music performance experiences. "Frisson Waves" is an exploratory real-time system to detect, trigger and share frisson in a wave-like pattern over audience members during music performances. The system consists of a physiological sensing wristband for detecting frisson and a thermo-haptic neckband for inducing frisson. In a controlled environment, we evaluate detection (n=19) and triggering of frisson (n=15). Based on our findings, we conducted an in-the-wild music concert with 48 audience members using our system to share frisson. This paper summarizes a framework for accessing, triggering and sharing frisson. We report our research insights, lessons learned, and limitations of "Frisson Waves". Yan He, George Chernyshov, Jiawen Han, Dingding Zheng, Ragnar Thomsen, Danny Hynds, Muyu Liu, Yuehui Yang, Yulan Ju, Yun Suen Pai, Kouta Minamizawa, Kai Kunze, and Jamie A War

Exome Sequencing Identifies ZNF644 Mutations in High Myopia

Myopia is the most common ocular disorder worldwide, and high myopia in particular is one of the leading causes of blindness. Genetic factors play a critical role in the development of myopia, especially high myopia. Recently, the exome sequencing approach has been successfully used for the disease gene identification of Mendelian disorders. Here we show a successful application of exome sequencing to identify a gene for an autosomal dominant disorder, and we have identified a gene potentially responsible for high myopia in a monogenic form. We captured exomes of two affected individuals from a Han Chinese family with high myopia and performed sequencing analysis by a second-generation sequencer with a mean coverage of 30× and sufficient depth to call variants at ∼97% of each targeted exome. The shared genetic variants of these two affected individuals in the family being studied were filtered against the 1000 Genomes Project and the dbSNP131 database. A mutation A672G in zinc finger protein 644 isoform 1 (ZNF644) was identified as being related to the phenotype of this family. After we performed sequencing analysis of the exons in the ZNF644 gene in 300 sporadic cases of high myopia, we identified an additional five mutations (I587V, R680G, C699Y, 3′UTR+12 C>G, and 3′UTR+592 G>A) in 11 different patients. All these mutations were absent in 600 normal controls. The ZNF644 gene was expressed in human retinal and retinal pigment epithelium (RPE). Given that ZNF644 is predicted to be a transcription factor that may regulate genes involved in eye development, mutation may cause the axial elongation of eyeball found in high myopia patients. Our results suggest that ZNF644 might be a causal gene for high myopia in a monogenic form

The oyster genome reveals stress adaptation and complexity of shell formation

The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy, along with transcriptomes of development and stress response and the proteome of the shell. The oyster genome is highly polymorphic and rich in repetitive sequences, with some transposable elements still actively shaping variation. Transcriptome studies reveal an extensive set of genes responding to environmental stress. The expansion of genes coding for heat shock protein 70 and inhibitors of apoptosis is probably central to the oyster's adaptation to sessile life in the highly stressful intertidal zone. Our analyses also show that shell formation in molluscs is more complex than currently understood and involves extensive participation of cells and their exosomes. The oyster genome sequence fills a void in our understanding of the Lophotrochozoa. © 2012 Macmillan Publishers Limited. All rights reserved