52 research outputs found
EFFECTS OF COLCHICINE AND UREA ON BETA-ADRENERGIC RECEPTOR - MEDIATED RELAXATION OF RAT AORTA
No abstrac
BETA ADRENERGIC BLOCKERS AND LIPID METABOLISM. I. CHANGES OF SERUM FREE FATTY ACIDS AFTER SINGLE PROPRANOLOL APPLICATION IN RATS
No abstrac
BETA-ADRENERGIC BLOCKERS AND LIPID METABOLISM. II. EFFECT OF REPEATED PROPRANOLOL APPLICATION ON SERUM FREE FATTY ACID LEVELS
No abstrac
EFFECT OF ISOTEOLINE IN ANIMAL MODELS PREDICTIVE OF ANTIDEPRESSANT ACTIVITY
Isoteoline, a compound of aporphine structure, was studied for antidepressant activity. Two animal models were used: the behavioral despair test and the clonidine-induced hypothermia. Isoteoline failed to alter the immobility time in rats subjected to forced swimming, but antagonized the immobility-reducing effect of desipramine, both after a single and multiple administration. In rats made hypothermic by i.p. injection of clonidine, Isoteoline did not antagonize the effect on rectal temperature, but rather accentuated it. The conclusion was made that Isoteoline was devoid of antidepressant activity. The results were analyzed in terms of previously demonstrated interactions of Isoteoline with subtypes of serotonergic receptors and were found to provide further evidence in support of these interactions
A COMPARATIVE STUDY ON THE EFFECT OF MONO- AND DITHIOL ANTIDOTES ON CELL DIVISION AND NUCLEOLUS FORMATION IN ACUTE MERCURY BICHLORIDE INTOXICATION
No abstrac
- …