Aberrant Functional and Causal Connectivity in Acute Tinnitus With Sensorineural Hearing Loss

Purpose: The neural bases in acute tinnitus remains largely undetected. The objective of this study was to identify the alteration of the brain network involved in patients with acute tinnitus and hearing loss. Methods: Acute tinnitus patients (n = 24) with hearing loss and age-, sex-, education-matched healthy controls (n = 21) participated in the current study and underwent resting-state functional magnetic resonance imaging (fMRI) scanning. Regional homogeneity and amplitude of low-frequency fluctuation were used to investigate the local spontaneous neural activity and functional connectivity (FC), and Granger causality analysis (GCA) was used to analyze the undirected and directed connectivity of brain regions. Results: Compared with healthy subjects, acute tinnitus patients had a general reduction in FC between auditory and non-auditory brain regions. Based on FC analysis, the superior temporal gyrus (STG) revealed reduced undirected connectivity with non-auditory brain regions including the amygdala (AMYG), nucleus accumbens (NAc), the cerebellum, and postcentral gyrus (PoCG). Using the GCA algorithm, increased effective connectivity from the right AMYG to the right STG, and reduced connectivity from the right PoCG to the left NAc was observed in acute tinnitus patients with hearing loss. The pure-tone threshold was positively correlated with FC between the AMYG and STG, and negatively correlated with FC between the left NAc and the right PoCG. In addition, a negative association between the GCA value from the right PoCG to the left NAc and the THI scores was observed. Conclusion: Acute tinnitus patients have aberrant FC strength and causal connectivity in both the auditory and non-auditory cortex, especially in the STG, AMYG, and NAc. The current findings will provide a new perspective for understanding the neuropathophysiological mechanism in acute tinnitus

The potential mechanism of Aidi injection against neuroblastoma—an investigation based on network pharmacology analysis

Background: Aidi injection, a classic traditional Chinese medicine (TCM) formula, has been used on a broader scale in treating a variety of cancers. In this study, we aimed to explore the potential anti-tumor effects of Aidi injection in the treatment of neuroblastoma (NB) using network pharmacology (NP).Methods: To elucidate the anti-NB mechanism of Aidi injection, an NP-based approach and molecular docking validation were employed. The compounds and target genes were collected from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database and Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine (BATMAN-TCM) database. The protein–protein interaction network was constructed using the STRING database. clusterProfiler (R package) was utilized to annotate the bioinformatics of hub target genes. The gene survival analysis was performed on R2, a web-based genomic analysis application. iGEMDOCK was used for molecular docking validation, and GROMACS was utilized to validate molecular docking results. Furthermore, we investigated the anticancer effects of gomisin B and ginsenoside Rh2 on human NB cells using a cell viability assay. The Western blot assay was used to validate the protein levels of target genes in gomisin B- and ginsenoside Rh2-treated NB cells.Results: A total of 2 critical compounds with 16 hub target genes were identified for treating NB. All 16 hub genes could potentially influence the survival of NB patients. The top three genes (EGFR, ESR1, and MAPK1) were considered the central hub genes from the drug–compound–hub target gene–pathway network. The endocrine resistance and estrogen signaling pathways were identified as the therapeutic pathways using the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Gomisin B and ginsenoside Rh2 showed a good binding ability to the target protein in molecular docking. The results of cell experiments showed the anti-NB effect of gomisin B and ginsenoside Rh2. In addition, the administration of gomisin B over-regulated the expression of ESR1 protein in MYCN-amplified NB cells.Conclusion: In the present study, we investigated the potential pharmacological mechanisms of Aidi against NB and revealed the anti-NB effect of gomisin B, providing clinical evidence of Aidi in treating NB and establishing baselines for further research

Prediction Method of Cavitation Jet Wave Attenuation Based on Five-Equation Two-Fluid Model

In this paper, the seven-equation two-fluid flow model is streamlined to a five-equation numerical calculation method. This method is applied to predict the wave attenuation of the cavitation jet. Compared with 9 different experimental schemes in two separate laboratories, it is found that the velocity flow characteristics are different from normal transient flow when the cavitation jet is formed in the pipeline. Such a difference in velocity flow characteristics will cause changes in the prediction deviation of pressure response time and amplitude. A numerical method for predicting the attenuation of pressure fluctuation with the cavitation jet is presented taken into account these flow characteristics. In this method, the unsteady friction model is opened after the jet wave transmits 3–5 cycles, and the cavitation jet wave attenuation is well simulated. This calculation method could provide a research basis for pipeline leakage, vibration, noise, and other fields that need accurate pressure signals

Joint Design of Polar Coding and Physical Network Coding for Two-User Downlink Non-Orthogonal Multiple Access

In this paper, we propose a joint polar coding and physical network coding (PNC) for two−user downlink non−orthogonal multiple access (PN−DNOMA) channels, since the successive–interference–cancellation–aided polar decoding cannot be optimal for finite blocklength transmissions. In the proposed scheme, we first constructed the XORed message of two user messages. Then, the XORed message was superimposed with the message of the weak User 2 for broadcast. By doing so, we can utilize the PNC mapping rule and polar decoding to directly recover the message of User 1, while at User 2, we equivalently constructed a long−length polar decoder to obtain its user message. The channel polarization and decoding performance can be greatly improved for both users. Moreover, we optimized the power allocation of the two users with their channel conditions by considering the user fairness and the performance. The simulation results showed that the proposed PN−DNOMA can achieve performance gains of about 0.4−0.7 dB over the conventional schemes in two−user downlink NOMA systems

Joint Design of Polar Coding and Physical Network Coding for Two−User Downlink Non−Orthogonal Multiple Access

In this paper, we propose a joint polar coding and physical network coding (PNC) for two−user downlink non−orthogonal multiple access (PN−DNOMA) channels, since the successive–interference–cancellation–aided polar decoding cannot be optimal for finite blocklength transmissions. In the proposed scheme, we first constructed the XORed message of two user messages. Then, the XORed message was superimposed with the message of the weak User 2 for broadcast. By doing so, we can utilize the PNC mapping rule and polar decoding to directly recover the message of User 1, while at User 2, we equivalently constructed a long−length polar decoder to obtain its user message. The channel polarization and decoding performance can be greatly improved for both users. Moreover, we optimized the power allocation of the two users with their channel conditions by considering the user fairness and the performance. The simulation results showed that the proposed PN−DNOMA can achieve performance gains of about 0.4−0.7 dB over the conventional schemes in two−user downlink NOMA systems

Enhanced architecture and implementation of spectrum shaping codes

Spectral shaping codes are modulation codes widely used in communication and data storage systems. This research enhances the algorithms employed in constructing spectral shaping codes for hardware implementation. We present a parallel scrambling calculation with a time complexity of O(1). Second, in the minimum accumulated signal power (MASP) module, the sine-cosine accumulation needs to be determined by remainder with time complexity O(n2). We offer reduced MASP computations for short bit-width data, ROM storage, and addition pipelines. It can remove the remainder operation, reducing accumulated complexity to O(1). In addition, we present a search algorithm to generate segmented lines to replace the square operations in the MASP module. By employing the search algorithm and shift operations, we can reduce the complexity of the square from O(n2) to O(1). The implementation results reveal that the original and proposed MASPs yield nearly identical spectrum nulls. The encoder-decoder of the spectral shaping codes with proposed approaches consumes just 6% of the hardware resources when carried out with a Spartan6 XC6SLX25