Clinical Application of In Vitro Maturation of Oocytes

In vitro maturation (IVM) is a technique used to induce immature oocytes collected in different periods of embryonic growth. The rates vary for immature oocytes collected from different clinical sources to potentially develop into embryos and achieve live birth. As an effective treatment method, IVM can be used to treat patients with polycystic ovary syndrome (PCOS), ovarian hyperresponsiveness, and hyporesponsiveness, as well as to preserve the fertility of cancer patients. This technology has been used worldwide for the birth of thousands of healthy babies. The improvement in clinical IVM technology mainly focuses on the IVM medium and the optimization of the culture environment and operation process. At present, with the improvement in the in vitro fertilization (IVF) efficiency and culture systems, a natural cycle or mild stimulation may be more suitable for women receiving IVF treatments. A new treatment option was proposed to combine natural cycle/mild stimulation IVF with IVM. In particular, the combination of mild stimulation IVF and IVM is not only expected to become a viable alternative to current standard treatments but may also become a potential option of first-line treatment

Revisiting energy efficiency and energy related CO2 emissions: Evidence from RCEP economies

Since the last four decades, energy demand has been reached to the utmost level, which also leads to emissions and causes environmental degradation, global warming and climate change all over the world. In this sense, policy makers have suggested various measures including renewable adoption and energy efficiency. Current study aims to investigate the influence of economic growth, energy consumption, renewable electricity output, and energy efficiency on the energy related emissions. A panel of 12 RCEP economies are examined covering the period 1990-2020. Since the data follows irregular path, therefore a novel method of moment panel quantile regression is employed along with the Granger causality test. The empirical results indicate that economic growth and energy consumption significantly enhances energy related emissions, where the magnitude and significance level is found strengthening from lower to upper quantiles (Q0.25, Q0.50, Q0.75 and Q0.90). Conversely, renewable electricity and energy efficiency are the significant tools for lowering energy related emissions in the region. Additionally, a unidirectional causality is found from energy consumption and renewable electricity output to energy related emissions. However, a feedback effect is validated between economic growth, energy efficiency, and energy related emissions. Based on the empirical findings, this study suggests enhancement of renewable electricity output and adoption of energy efficient technologies to reduce environmental degradation and emission level

Ticking terahertz wave generation in attoseconds

We perform a joint measurement of terahertz waves and high-order harmonics generated from noble atoms driven by a fundamental laser pulse and its second harmonic. By correlating their dependence on the phase-delay of the two pulses, we determine the generation of THz waves in tens of attoseconds precision. Compared with simulations and models, we find that the laser-assisted soft-collision of the electron wave packet with the atomic core plays a key role. It is demonstrated that the rescattering process, being indispensable in HHG processes, dominant THz wave generation as well but in a more elaborate way. The new finding might be helpful for the full characterization of the rescattering dynamics.Comment: 4 figure

A role for the A3 adenosine receptor in determining tissue levels of cAMP and blood pressure: studies in knock-out mice

AbstractAdenosine administration has been reported to lower blood pressure by activating specific membrane receptors. The rat and human heart and aorta have been previously found to express both A2-type adenosine receptors, which activate adenylyl cyclase, and A3 adenosine receptors (A3AR), which inhibit adenylyl cyclase. In the current study, we used A3 adenosine receptor (A3AR) knock-out mice to examine the hypothesis that the relative levels of the A2-type adenosine receptors and A3AR determine the steady-state levels of cAMP in the cells and may affect blood pressure. We found that the A3AR knock-out mice express normal levels of the A1- and A2-type adenosine receptors. In situ hybridization demonstrated that the level of A3AR is high in the vascular smooth muscle layer of aortas derived from wild-type mice, but is not detectable in the knock-out mice. The steady-state level of cAMP is elevated in the aorta and heart of knock-out mice, as compared to wild-type mice, but is not altered in platelets, where A3AR is not expressed naturally. A3AR knock-out mice possess a blood pressure comparable to this in wild-type mice. However, when challenged with adenosine, the knock-out mice display a further increase in cAMP levels in the heart and vascular smooth muscle and a significant decrease in blood pressure, as compared to wild-type mice. In contrast, the effect of adenosine on ADP-induced platelet aggregation is similar in both types of mice. These studies indicate that the A3AR affects the steady-state level of cAMP in the tissues where it is naturally expressed, and that it influences the blood pressure in response to adenosine