505 research outputs found
BSD2000 Deep Hyperthermia Combined with Chemotherapy of PT regimen in Patients with Non-small Cell Lung Cancer
Background and objective The aim of this study is to determine the short-term efficacy, toxicity and the rate of life-quality improvement of BSD2000 deep hyperthermia combined with chemotherapy of PT regimen in patients with non-small cell lung cancer (NSCLC) by comparation with PT regimen alone. Methods Sixty patients with NSCLC were randomly divided into the treatment group and control group, with 30 each. The treatment group was treated with chemotherapy (paclitaxel:135mg/m2 ivdirp 3 h qd d1+cisplatin: 20 mg/m2 ivdirp qd d1-5) in combination with BSD2000 deep hyperthermia, and hyperthermia was positioned precisely and maintained for 60 min (2 times a cycle: d1, 4 after the end of chemotherapy within two hours). The control group was treated with chemotherapy alone. Treatment response in both groups were evaluated as well as side-effects after 3 cycles. By observing the results, comparing response rate, toxic side effects and quality of life improvement rate in two groups. Results The efficiency and the rate of life-quality improvement in the treatment group were 63.33%, 76.67% respectively, and 36.67%, 40.00% in the control group respectively. There were significant differences between two groups (P < 0.05). The main side-effects were myelosuppression and gastrointestinal reactions, no significant difference between two groups (P > 0.05). Conclusion BSD2000 deep hyperthermia combined with chemotherapy in patients with NSCLC can significantly increase the efficacy, response rate and quality of life improvement and without increasing sideeffects compared to chemotherapy alone
Space-Invariant Projection in Streaming Network Embedding
Newly arriving nodes in dynamics networks would gradually make the node
embedding space drifted and the retraining of node embedding and downstream
models indispensable. An exact threshold size of these new nodes, below which
the node embedding space will be predicatively maintained, however, is rarely
considered in either theory or experiment. From the view of matrix perturbation
theory, a threshold of the maximum number of new nodes that keep the node
embedding space approximately equivalent is analytically provided and
empirically validated. It is therefore theoretically guaranteed that as the
size of newly arriving nodes is below this threshold, embeddings of these new
nodes can be quickly derived from embeddings of original nodes. A generation
framework, Space-Invariant Projection (SIP), is accordingly proposed to enables
arbitrary static MF-based embedding schemes to embed new nodes in dynamics
networks fast. The time complexity of SIP is linear with the network size. By
combining SIP with four state-of-the-art MF-based schemes, we show that SIP
exhibits not only wide adaptability but also strong empirical performance in
terms of efficiency and efficacy on the node classification task in three real
datasets
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