Modeling And Optimization Of Non-Profit Hospital Call Centers With Service Blending

This dissertation focuses on the operations problems in non-profit hospital call centers with inbound and outbound calls service blending. First, the routing policy for inbound and outbound calls is considered. The objective is to improve the system utilization under constraints of service quality and operators\u27 quantity. A collection of practical staffing assignment methods, separating and mixing staffing policy are evaluated. Erlang C queuing model is used to decide the minimum number of operators required by inbound calls. Theoretical analysis and numerical experiments illustrate that through dynamically assigning the inbound and outbound calls to operators under optimal threshold policy, mixing staffing policy is efficient to balance the system utilization and service quality. Numerical experiments based on real-life data demonstrate how this method can be applied in practice. Second, we study the staffing shift planning problem based on the inbound and outbound calls routing policies. A mathematical programming model is developed, based on a hospital call center with one kind of inbound calls and multiple kinds of outbound calls. The objective is to minimize the staffing numbers, by deciding the shift setting and workload allocation. The inbound calls service level and staffing utilization are taken into consideration in the constraints. Numerical experiments based on actual operational data are included. Results show that the model is effective to optimize the shift planning and hence reduce the call centers\u27 cost. Third, we model the staffing shift planning problem for a hospital call center with two kinds of service lines. Each kind of service is delivered through both inbound calls and outbound calls. The inbound calls can be transferred between these two service lines. A mathematical programming model is developed. The objective is to minimize the staffing cost, by deciding the shift setting and workload allocation. The inbound calls service level and staffing utilization are taken into consideration in the constraints. Numerical experiments are carried out based on actual operational data. Results show that the model is effective to reduce the call centers\u27 labor cost

Electrical Transport Properties of Multilayered Single-Walled Carbon Nanotube Films

An improved layer-by-layer vacuum filtration method was adopted for the fabrication of single-walled carbon nanotube (SWCNT) films aiming at a series of SWCNT films with controllable thickness and density. The electrical transport properties of the multilayered SWCNT films have been investigated. With the constant film density, the decrease of the layer number of the SWCNT film results in an increase of the temperature coefficient of resistance (TCR). SWCNT film with 95% metallic nanotubes has shown a lower TCR than that of the SWCNT films with a low percentage of metallic nanotubes. The effect of thermal annealing and subsequent acid (HNO3) treatment on the electrical properties of the SWCNT films has also been investigated

Investigation of nedaplatin and CpG oligodeoxynucleotide combination therapy in a mouse model of lung cancer

Purpose: To investigate the anti-tumor effects of nedaplatin (NDP) and CpG oligodeoxynucleotide (CpG-ODN) combination therapy in a mouse-modeled lung cancer.Methods: To evaluate the anti-tumor effects of NDP and CpG-ODN combination therapy, a lung cancer xenograft mouse model was established by subcutaneous injection of LA-795 cells. BALB/c mice were divided into four groups as follows: NDP, CpG-, NDP + CpG-ODN and untreated control group. The sections of lung cancer tissue were stained with hematoxylin and eosin (H&E) and morphologically examined. Spleen, body weight, and spleen index were measured. Flow cytometry was used to determine the proportions of CD3+, CD8+, CD4+ and CD4+/CD8+ in mice blood cells. Serum levels of interferon-γ (IFN-γ) and interleukin-12 (IL-12) were measured by enzyme-linked immunosorbent assay (ELISA).Results: NDP + CpG-ODN therapy significantly reduced tumor volume and prolonged the survival time of tumor-bearing mice. NDP + CpG-ODN induced a change in cancer cell morphology, including large areas of necrosis which correlated with a reduction in tumor size. NDP + CpG-ODN significantly increased spleen weight/index and dramatically enhanced immune cell activation. This was evident in the increase serum levels of IFN-γ and IL-12.Conclusion: NDP and CpG-ODN combination therapy inhibits the growth of lung cancer and prolongs the survival time of tumor-bearing mice. This may result from the activation of immune cells and increased expression of IFN-γ and IL-12.Keywords: CpG ODN, NDP, Lung cancer, Combination therap

Integration on acceleration signals by adjusting with envelopes

Direct integration of acceleration often causes unrealistic drifts in velocity and displacement. A method of integration on acceleration data to acquire realistic velocity and displacement is proposed. In this approach, drifts are estimated by using the mean of the upper and lower envelopes of signals after integration from acceleration into velocity and displacement. The experimental results obtained by using simulated data and real world signals are presented to demonstrate the effectiveness of the method

Fractional Order Stochastic Differential Equation with Application in European Option Pricing

Memory effect is an important phenomenon in financial systems, and a number of research works have been carried out to study the long memory in the financial markets. In recent years, fractional order ordinary differential equation is used as an effective instrument for describing the memory effect in complex systems. In this paper, we establish a fractional order stochastic differential equation (FSDE) model to describe the effect of trend memory in financial pricing. We, then, derive a European option pricing formula based on the FSDE model and prove the existence of the trend memory (i.e., the mean value function) in the option pricing formula when the Hurst index is between 0.5 and 1. In addition, we make a comparison analysis between our proposed model, the classic Black-Scholes model, and the stochastic model with fractional Brownian motion. Numerical results suggest that our model leads to more accurate and lower standard deviation in the empirical study

Rapid detection of moisture content of pineapple based on near infrared spectroscopy and SSA-RELM

Objective: A method for a fast and non-destructive detection of pineapple moisture content was established. Methods: A novel detection model of pineapple moisture content was proposed based on continuous projection feature wavelength selection and Sparrow search algorithm. Firstly, according to the characteristic of pineapple NIR data with high dimension and redundant information, the results of feature wavelength selection such as successive projections algorithm, principal component analysis and full-band were compared, the selection method of characteristic wavelength of pineapple near infrared spectrum was determined. Secondly, considering that the performance of RELM model was affected by the selection of input layer weight and hidden layer bias, the sparrow search algorithm was used to optimize the input layer weight and hidden layer bias of RELM model, a novel pineapple moisture content detection model based on RELM model improved by sparrow search algorithm was proposed. Results: compared with GA-RELM, PSO-RELM and RELM, the detection model based on SSA-RELM had the highest detection accuracy. Conclusion: RELM model is optimized by sparrow search algorithm can effectively improve the detection accuracy of RELM model

Quantum Hydrodynamic Model by Moment Closure of Wigner Equation

In this paper, we derive the quantum hydrodynamics models based on the moment closure of the Wigner equation. The moment expansion adopted is of the Grad type firstly proposed in \cite{Grad}. The Grad's moment method was originally developed for the Boltzmann equation. In \cite{Fan_new}, a regularization method for the Grad's moment system of the Boltzmann equation was proposed to achieve the globally hyperbolicity so that the local well-posedness of the moment system is attained. With the moment expansion of the Wigner function, the drift term in the Wigner equation has exactly the same moment representation as in the Boltzmann equation, thus the regularization in \cite{Fan_new} applies. The moment expansion of the nonlocal Wigner potential term in the Wigner equation is turned to be a linear source term, which can only induce very mild growth of the solution. As the result, the local well-posedness of the regularized moment system for the Wigner equation remains as for the Boltzmann equation

Semisynthetic Macrocyclic Lipo-lanthipeptides Display Antimicrobial Activity Against Bacterial Pathogens

[Image: see text] A large number of antimicrobial peptides depend on intramolecular disulfide bonds for their biological activity. However, the relative instability of disulfide bonds has limited the potential of some of these peptides to be developed into therapeutics. Conversely, peptides containing intramolecular (methyl)lanthionine-based bonds, lanthipeptides, are highly stable under a broader range of biological and physical conditions. Here, the class-II lanthipeptide synthetase CinM, from the cinnamycin gene cluster, was employed to create methyllanthionine stabilized analogues of disulfide-bond-containing antimicrobial peptides. The resulting analogues were subsequently modified in vitro by adding lipid tails of variable lengths through chemical addition. Finally, the created compounds were characterized by MIC tests against several relevant pathogens, killing assays, membrane permeability assays, and hemolysis assays. It was found that CinM could successfully install methyllanthionine bonds at the intended positions of the analogues and that the lipidated macrocyclic core peptides have bactericidal activity against tested Gram-positive and Gram-negative pathogenic bacteria. Additionally, fluorescence microscopy assays revealed that the lipidated compounds disrupt the bacterial membrane and lyse bacterial cells, hinting toward a potential mode of action. Notably, the semisynthesized macrocyclic lipo-lanthipeptides show low hemolytic activity. These results show that the methods developed here extend the toolbox for novel antimicrobial development and might enable the further development of novel compounds with killing activity against relevant pathogenic bacteria

Research on Advanced Treatment Technology of Fluorine Containing Wastewater from Graphite Production

With the gradual improvement of environmental emission requirements in China, the graphite industry is facing environmental pressure from advanced treatment. This article first conducted a study on the current status of advanced treatment technology for fluorinated wastewater. Subsequently, a single defluorination agent experiment was conducted, and it was found that compared to several agents used in the experiment, such as PAC, PAFS, and CaCl2, PAC had the best defluorination effect. The optimization of PAC conditions showed that its optimal reaction pH was 7, and equilibrium could be achieved after 3 minutes of reaction. The study also conducted orthogonal experiments with mixed salts, and the best conditions for the combination of fluoride removal agents were found to be PAC adding 400 mg/L, CaCl2 adding 400 mg/L, PAFS adding 200 mg/L, which can remove fluoride to 0.92 mg/L, below 1 mg/L, meeting the Class III water standard in the " Environmental quality standards for surface water ".The SEM image of the sludge generated by the reaction between the composite fluoride removal agent and fluoride containing wastewater shows a larger particle size of up to 50 μm which is beneficial for the separation and removal of sludge. The generated sediment sludge is mainly composed of Al, Fe, Ca, O, and Si according to EDS results, and belongs to general industrial solid waste.publishedVersio

A Meta-Analysis of Choroidal Thickness Changes in Unilateral Amblyopia

Purpose. To date, the topic of amblyopic changes remains controversial. Therefore, a systematic review and meta-analysis were carried out to evaluate choroidal changes in unilateral amblyopia. Methods. Major literature databases were searched for amblyopia-relevant studies. Using enhanced depth imaging optical coherence tomography (EDI-OCT), the primary outcome parameters examined were subfoveal choroidal thickness (SFCT) and different choroidal thickness (CT) positions. Efficacy estimates were evaluated by weighted mean difference (WMD) and 95% confidence interval (CI) for choroidal-associated changes. We performed subgroup analysis and metaregression analysis to examine potential sources of heterogeneity. Results. Eleven cross-sectional studies that included a total of 768 participants were identified. The amblyopic eye SFCT was thicker than that of the fellow and control (normal) eyes (WMDamblyopia versus fellow=49.24, 95% CI of 30.22 to 68.27, p<0.001; WMDamblyopia versus control=54.51, 95% CI of 32.17 to 76.85, p<0.001). There were no differences between the fellow and control eyes (WMD=13.81, 95% CI of 1.16 to 28.77, p=0.071). Subgroup and metaregression analyses indicated that the OCT type was the main source of heterogeneity. Conclusions. The CT in the amblyopic eyes was thicker than that in the fellow and control eyes