Preparation and Photocatalytic Activity of Fe3+ - doped TiO2 Modified

Photocatalytic materials of TiO2 / coarse silica gel microspheres were prepared by sol-gel impregnation method and doped with transition metal ions Fe3+ to form Fe3+ modified TiO2 / coarse silica gel microspheres. The surface of the Fe modified photocatalytic materials were analyzed by XRD and surface scanning. Degradation of reactive dyes using X-3B dye wastewater water samples for validation tests. The results show that the photocatalytic activity of the photocatalytic material reaches the best when the Fe doping amount is 0.5%, and the most photocatalyst amount is 10g / L. The degradation rate of COD under this dosage was 72.32%. At the same time, according to the characterization analysis, it was found that Fe did not react with the photocatalytic material of TiO2 / coarse silica microspheres in the reaction, Fe increased the defect structure of TiO2 surface and promoted the formation of anatase, A red shift occurred and the corresponding range of the spectrum expanded toward the visible region. The results show that the doping of Fe affects the formation of TiO2 crystals, but increases the photocatalytic efficiency of TiO2

RESEARCH ON UNBALANCED WEIGHING EXPERIMENT OF MULTI-POINT BRACED SWIVEL CABLE-STAYED BRIDGE

To guarantee the safety of the swivel process, the weighing experiment before the swivel is especially important. Based on this, this paper takes a twin-tower, double-cable prestressed concrete swivel cable-stayed bridge as the background and suggests a multi-point braced swivel weighing experiment involving the joint force of the arm-brace and the spherical hinge to solve problems such as a particular obstacle in the relying project's swivelling process. Firstly, the relevant weighing experiment formulas for various circumstances were theoretically derived. The field test results were then used to calculate the jacking force at the limit state during the jacking process, which was then substituted into the relevant formulae, and the relevant parameters of the weighing experiment were calculated. Finally, the counterweight is adjusted based on the weighing results to carry out the structural rotation. The angular velocity was stable during the swivelling process, and the structure was successfully swivelled. The successful practice of a multi-point braced swivel weighing experiment involving the joint force of the arm-brace, and the spherical hinge can provide a reference for the design and construction of similar bridges

Human ApoE ε2 promotes regulatory mechanisms of bioenergetic and synaptic function in female brain: a focus on V-type H+-ATPase

Humans possess three major isoforms of the apolipoprotein E (ApoE) gene encoded by three alleles: ApoE ε2 (ApoE2), ApoE ε3 (ApoE3), and ApoE ε4 (ApoE4). It is established that the three ApoE isoforms confer differential susceptibility to Alzheimer’s disease (AD); however, an in-depth molecular understanding of the underlying mechanisms is currently unavailable. In this study, we examined the cortical proteome differences among the three ApoE isoforms using 6-month-old female, human ApoE2, ApoE3, and ApoE4 gene-targeted replacement mice and two-dimensional proteomic analyses. The results reveal that the three ApoE brains differ primarily in two areas: cellular bioenergetics and synaptic transmission. Of particular significance, we show for the first time that the three ApoE brains differentially express a key component of the catalytic domain of the V-type H+-ATPase (Atp6v), a proton pump that mediates the concentration of neurotransmitters into synaptic vesicles and thus is crucial in synaptic transmission. Specifically, our data demonstrate that ApoE2 brain exhibits significantly higher levels of the B subunit of Atp6v (Atp6v1B2) when compared to both ApoE3 and ApoE4 brains, with ApoE4 brain exhibiting the lowest expression. Our additional analyses show that Atp6v1B2 is significantly impacted by aging and AD pathology and the data suggest that Atp6v1B2 deficiency could play a role in the progressive loss of synaptic integrity during early development of AD. Collectively, our findings indicate that human ApoE isoforms differentially modulate regulatory mechanisms of bioenergetic and synaptic function in female brain. A more efficient and robust status in both areas could serve as a potential mechanism contributing to the neuroprotective and cognition-favoring properties associated with the ApoE2 genotype

Endoscopic rhizotomy for chronic lumbar zygapophysial joint pain.

BACKGROUND: Chronic lumbar zygapophysial joint pain is a common cause of chronic low back pain. Percutaneous radiofrequency ablation (RFA) is one of the effective management options; however, the results from the traditional RFA need to be improved in certain cases. The aim of this study is to investigate the effect of percutaneous radiofrequency ablation under endoscopic guidance (ERFA) for chronic low back pain secondary to facet joint arthritis. METHODS: This is a prospective study enrolled 60 patients. The cases were randomized into two groups: 30 patients in the control group underwent traditional percutaneous radiofrequency ablation, others underwent ERFA. The lumbar visual analog scale (VAS), MacNab score, and postoperative complications were used to evaluate the outcomes. All outcome assessments were performed at postoperative 1 day, 1 month, 3 months, 6 months, and 12 months. RESULTS: There was no difference between the two groups in preoperative VAS (P \u3e 0.05). VAS scores, except the postoperative first day, in all other postoperative time points were significantly lower than preoperative values each in both groups (P \u3c 0.05). There was no significant difference between the two groups in VAS at 1 day, 1 month, and 3 months after surgery (P \u3e 0.05). However, the EFRA demonstrated significant benefits at the time points of 3 months and 6 months (P \u3e 0.05). The MacNab scores of 1-year follow-up in the ERFA group were higher than that in the control group (P \u3c 0.05). The incidence of complications in the ERFA group was significantly less than that in the control group (P \u3c 0.05). CONCLUSIONS: ERFA may achieve more accurate and definite denervation on the nerves, which leads to longer lasting pain relief

Temporal and Quantitative Analysis of Atherosclerotic Lesions in Diet-Induced Hypercholesterolemic Rabbits

The diet-induced atherosclerotic rabbit is an ideal model for atherosclerosis study, but temporal changes in atherosclerotic development in hypercholesterolemic rabbits are poorly understood. Japanese white rabbits were fed a high-cholesterol diet to induce sustained hypercholesterolemia, and each group of 10–12 animals was then sacrificed at 6, 12, 16, or 28 weeks. The rabbit aortas were harvested, and the sizes of the gross and intima atherosclerotic lesions were quantified. The cellular component of macrophages (Mφs) and smooth muscle cells (SMCs) in aortic intimal lesions was also quantified by immunohistochemical staining, and the correlation between plasma cholesterol levels and the progress of atherosclerotic lesions was studied. The ultrastructure of the atherosclerotic lesions was observed by transmission electron microscopy (TEM). Widely variable atherosclerotic plaques were found from 6 weeks to 28 weeks, and the lesional progress was closely correlated with cholesterol exposure. Interestingly, a relatively reduced accumulation of Mφ, an increased numbers of SMCs, and a damaged endothelial layer were presented in advanced lesions. Moreover, SMCs were closely correlated with cholesterol exposure and lesional progress for the whole period. Cholesterol exposure directly determines atherosclerotic progress in a rabbit model, and the changes in the cellular component of advanced lesions may affect plaque stability in an atherosclerotic rabbit model