235 research outputs found
OpenDigger: Data Mining and Information Service System for Open Collaboration Digital Ecosystem
The widespread development and adoption of open-source software have built an
ecosystem for open development and collaboration. In this ecosystem,
individuals and organizations collaborate to create high-quality software that
can be used by everyone. Social collaboration platforms like GitHub have
further facilitated large-scale, distributed, and fine-grained code
collaboration and technical interactions. Countless developers contribute code,
review code, report bugs, and propose new features on these platforms every
day, generating a massive amount of valuable behavioral data from the open
collaboration process. This paper presents the design and implementation of
OpenDigger, a comprehensive data mining and information service system for open
collaboration in the digital ecosystem. The goal is to build a data
infrastructure for the open-source domain and promote the continuous
development of the open-source ecosystem. The metrics and analysis models in
the OpenDigger system can mine various knowledge from the macro to micro levels
in the open-source digital ecosystem. Through a unified information service
interface, OpenDigger provides various open-source information services to
different user groups, including governments, enterprises, foundations, and
individuals. As a novel information service system in the open-source
ecosystem, this paper demonstrates the effectiveness of the metrics and models
in OpenDigger through several real-world scenarios, including products, tools,
applications, and courses. It showcases the significant and diverse practical
applications of the metrics and models in both algorithmic and business
aspects.Comment: in Chinese languag
Bifurcation analysis and classification of all single traveling wave solution in fiber Bragg gratings with Radhakrishnan-Kundu-Lakshmanan equation
The current work studies the bifurcation and the classification of single traveling wave solutions of the coupled version of Radhakrishnan-Kundu-Lakshmanan equation that usually describes the dynamics of optical pulses in fiber Bragg gratings, which is also described by a family of nonlinear Schrödinger equations with cubic nonlinear terms. The solutions of the hyperbolic functions, the rational functions, the trigonometric functions and the Jacobian functions are retrieved by using the complete discrimination system of polynomial. By selecting appropriate parameters, phase portraits, two-dimension graphics and three-dimension graphics of the obtained solutions are drawn
OA-Bug: An Olfactory-Auditory Augmented Bug Algorithm for Swarm Robots in a Denied Environment
Searching in a denied environment is challenging for swarm robots as no
assistance from GNSS, mapping, data sharing, and central processing is allowed.
However, using olfactory and auditory to cooperate like animals could be an
important way to improve the collaboration of swarm robots. In this paper, an
Olfactory-Auditory augmented Bug algorithm (OA-Bug) is proposed for a swarm of
autonomous robots to explore a denied environment. A simulation environment is
built to measure the performance of OA-Bug. The coverage of the search task
using OA-Bug can reach 96.93%, with the most significant improvement of 40.55%
compared with a similar algorithm, SGBA. Furthermore, experiments are conducted
on real swarm robots to prove the validity of OA-Bug. Results show that OA-Bug
can improve the performance of swarm robots in a denied environment.Comment: 7 pages, 5 figure
A BrLINE1-RUP insertion in BrCER2 alters cuticular wax biosynthesis in Chinese cabbage (Brassica rapa L. ssp. pekinensis)
Glossiness is an important quality-related trait of Chinese cabbage, which is a leafy vegetable crop in the family Brassicaceae. The glossy trait is caused by abnormal cuticular wax accumulation. In this study, on the basis of a bulked segregant analysis coupled with next-generation sequencing (BSA-seq) and fine-mapping, the most likely candidate gene responsible for the glossy phenotype of Chinese cabbage was identified. It was subsequently named Brcer2 because it is homologous to AtCER2 (At4g24510). A bioinformatics analysis indicated a long interspersed nuclear element 1 (LINE-1) transposable element (named BrLINE1-RUP) was inserted into the first exon of Brcer2 in HN19-G via an insertion-mediated deletion mechanism, which introduced a premature termination codon. Gene expression analysis showed that the InDel mutation of BrCER2 reduced the transcriptional expression levels of Brcer2 in HN19-G. An analysis of cuticular waxes suggested that a loss-of-function mutation to BrCER2 in Chinese cabbage leads to a severe decrease in the abundance of very-long-chain-fatty-acids (> C28), resulting in the production of a cauline leaf, inflorescence stem, flower, and pistil with a glossy phenotype. These findings imply the insertion of the LINE-1 transposable element BrLINE1-RUP into BrCER2 can modulate the waxy traits of Chinese cabbage plants
Abnormal expression of SLIT3 induces intravillous vascularization dysplasia in ectopic pregnancy
Objective To investigate whether the morphology, capillary number, and transcriptome expression profiles of ectopic pregnancy (EP) villi differ from those of normal pregnancy (NP) villi. Methods Hematoxylin-eosin (HE) and immunohistochemistry (IHC) staining for CD31 were conducted to compare differences in morphology and capillary number between EP and NP villi. Differentially expressed (DE) miRNAs and mRNAs were determined from transcriptome sequencing of both types of villi and used to construct a miRNA–mRNA network, from which hub genes were identified. Candidate DE-miRNAs and DE-mRNAs were validated by quantitative reverse transcription (qRT)-PCR. Correlations were identified between the number of capillaries and serum beta human chorionic gonadotropin (β-HCG) levels and between the expression levels of hub genes associated with angiogenesis and β-HCG levels. Results The mean and total cross-sectional areas of placental villi were significantly increased in EP compared with NP villi. Capillary density was greatly reduced in EP villi and was positively correlated with β-HCG levels. A total of 49 DE-miRNAs and 625 DE-mRNAs were identified from the sequencing data. An integrated analysis established a miRNA–mRNA network containing 32 DE-miRNAs and 103 DE-mRNAs. Based on the validation of hub mRNAs and miRNAs in the network, a regulatory pathway involving miR-491-5p–SLIT3 was discovered, which may have a role in the development of villous capillaries. Conclusion Villus morphology, capillary number, and miRNA/mRNA expression profiles in villous tissues were aberrant in EP placentas. Specifically, SLIT3, which is regulated by miR-491-5p, may contribute to the regulation of villous angiogenesis and was established as a putative predictor of chorionic villus development, providing a basis for future research
The Role of Tumour Metabolism in Cisplatin Resistance
Cisplatin is a chemotherapy drug commonly used in cancer treatment. Tumour cells are more sensitive to cisplatin than normal cells. Cisplatin exerts an antitumour effect by interfering with DNA replication and transcription processes. However, the drug-resistance properties of tumour cells often cause loss of cisplatin efficacy and failure of chemotherapy, leading to tumour progression. Owing to the large amounts of energy and compounds required by tumour cells, metabolic reprogramming plays an important part in the occurrence and development of tumours. The interplay between DNA damage repair and metabolism also has an effect on cisplatin resistance; the molecular changes to glucose metabolism, amino acid metabolism, lipid metabolism, and other metabolic pathways affect the cisplatin resistance of tumour cells. Here, we review the mechanism of action of cisplatin, the mechanism of resistance to cisplatin, the role of metabolic remodelling in tumorigenesis and development, and the effects of common metabolic pathways on cisplatin resistance
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