Research on the Integrated Development of Sports Tourism Resources and Health Care Industry on the Background of “Healthy China” Taking the Zodong Area of Garze Prefecture as an Example

Since the 18th National Congress of the Communist Party of China, with the gradual improvement of people’s living standards and the comprehensive progress of social development, especially after the implementation of the strategy of strengthening China through sports, the comprehensive strength shown by China cannot be underestimated. The people’s cognition of the impact of sports activities on health is constantly changing, and the people’s investment in health is becoming more rational and diversified. The leisure sports tourism and health convalescence industry are gradually developing and integrating with each other. Under the new development opportunities, the basic conditions and dilemmas of the development of the combination of tourism, sports and health care in the Zodong Area of Garze Prefecture are analyzed. Combined with the rich tourism resources, obvious geographical advantages and unique national culture, a new industry trend combining tourism, sports and health care is created in accordance with local conditions in sports tourism and health convalescence, providing new impetus for the high-quality development of local economy

Improved SVD + + Recommendation Algorithm Based on Fusion Time Factor

Collaborative filtering algorithm is widely used in recommendation system. Aiming at the problems of data sparsity and low recommendation accuracy in traditional collaborative filtering algorithm, an improved recommendation algorithm is proposed PT _ SVD++. Firstly, the attribute information of users and the implicit feedback information of items are introduced to improve the SVD++ algorithm, which solves the insufficient utilization of information and alleviates the problem of sparse data；Secondly the time effect model is established to further improve the accuracy of the prediction results. The experimental results on MovieLens dataset show that compared with other algorithms, the average absolute error and root mean square error of this algorithm are lower, and its recommendation accuracy is higher

Genomic applications of statistical signal processing

Biological phenomena in the cells can be explained in terms of the interactions among biological macro-molecules, e.g., DNAs, RNAs and proteins. These interactions can be modeled by genetic regulatory networks (GRNs). This dissertation proposes to reverse engineering the GRNs based on heterogeneous biological data sets, including time-series and time-independent gene expressions, Chromatin ImmunoPrecipatation (ChIP) data, gene sequence and motifs and other possible sources of knowledge. The objective of this research is to propose novel computational methods to catch pace with the fast evolving biological databases. Signal processing techniques are exploited to develop computationally efficient, accurate and robust algorithms, which deal individually or collectively with various data sets. Methods of power spectral density estimation are discussed to identify genes participating in various biological processes. Information theoretic methods are applied for non-parametric inference. Bayesian methods are adopted to incorporate several sources with prior knowledge. This work aims to construct an inference system which takes into account different sources of information such that the absence of some components will not interfere with the rest of the system. It has been verified that the proposed algorithms achieve better inference accuracy and higher computational efficiency compared with other state-of-the-art schemes, e.g. REVEAL, ARACNE, Bayesian Networks and Relevance Networks, at presence of artificial time series and steady state microarray measurements. The proposed algorithms are especially appealing when the the sample size is small. Besides, they are able to integrate multiple heterogeneous data sources, e.g. ChIP and sequence data, so that a unified GRN can be inferred. The analysis of biological literature and in silico experiments on real data sets for fruit fly, yeast and human have corroborated part of the inferred GRN. The research has also produced a set of potential control targets for designing gene therapy strategies

Recovering Genetic Regulatory Networks from Chromatin Immunoprecipitation and Steady-State Microarray Data

<p/> <p>Recent advances in high-throughput DNA microarrays and chromatin immunoprecipitation (ChIP) assays have enabled the learning of the structure and functionality of genetic regulatory networks. In light of these heterogeneous data sets, this paper proposes a novel approach for reconstruction of genetic regulatory networks based on the posterior probabilities of gene regulations. Built within the framework of Bayesian statistics and computational Monte Carlo techniques, the proposed approach prevents the dichotomy of classifying gene interactions as either being connected or disconnected, thereby it reduces significantly the inference errors. Simulation results corroborate the superior performance of the proposed approach relative to the existing state-of-the-art algorithms. A genetic regulatory network for <it>Saccharomyces cerevisiae</it> is inferred based on the published real data sets, and biological meaningful results are discussed.</p

Spectral Preprocessing for Clustering Time-Series Gene Expressions

<p/> <p>Based on gene expression profiles, genes can be partitioned into clusters, which might be associated with biological processes or functions, for example, cell cycle, circadian rhythm, and so forth. This paper proposes a novel clustering preprocessing strategy which combines clustering with spectral estimation techniques so that the time information present in time series gene expressions is fully exploited. By comparing the clustering results with a set of biologically annotated yeast cell-cycle genes, the proposed clustering strategy is corroborated to yield significantly different clusters from those created by the traditional expression-based schemes. The proposed technique is especially helpful in grouping genes participating in time-regulated processes.</p

Identifying Genes Involved in Cyclic Processes by Combining Gene Expression Analysis and Prior Knowledge

Based on time series gene expressions, cyclic genes can be recognized via spectral analysis and statistical periodicity detection tests. These cyclic genes are usually associated with cyclic biological processes, for example, cell cycle and circadian rhythm. The power of a scheme is practically measured by comparing the detected periodically expressed genes with experimentally verified genes participating in a cyclic process. However, in the above mentioned procedure the valuable prior knowledge only serves as an evaluation benchmark, and it is not fully exploited in the implementation of the algorithm. In addition, partial data sets are also disregarded due to their nonstationarity. This paper proposes a novel algorithm to identify cyclic-process-involved genes by integrating the prior knowledge with the gene expression analysis. The proposed algorithm is applied on data sets corresponding to Saccharomyces cerevisiae and Drosophila melanogaster, respectively. Biological evidences are found to validate the roles of the discovered genes in cell cycle and circadian rhythm. Dendrograms are presented to cluster the identified genes and to reveal expression patterns. It is corroborated that the proposed novel identification scheme provides a valuable technique for unveiling pathways related to cyclic processes