Experimental study on mechanical properties of filling-bulk ce-menting combination body

In order to study the influence of caved rocks in the goaf on the backfilling body in the backfilling mining, uniaxial compression test are carried out on the backfilling body-cemented granular body combination with different granular heights, discrete element lithology and backfilling body strength. The uniaxial compression failure of the combination body specimen is monitored in real time by using the three-dimensional acoustic emission positioning technology. The deformation and failure corresponding to the AE events in the loading process is characterized by combining the time parameters of AE events with the starting time points of the four stages of the stress-strain curve. Based on this, the failure model for the interface of the combination body is established. The results show that the height of granular is negatively correlated with the strength of the combination body, and the uniaxial compressive strength of the combination body with the backfilling height ratio of 1:4 is only 55.0 % of that of the single backfilling body. The discrete element lithology and the strength of backfilling body are positively correlated with the strength of the combination body. Although high-strength backfilling body can improve the uniaxial compressive strength of the combination body, the higher the strength of filling body in the combination body, the more serious the strength reduction of the combination body. When the particle lithology in cemented bulk is siltstone with low strength, the uniaxial compressive strength of the combination body is only 42.9% of that of single combination body. The siltstone with smaller compressive strength will have a fracture plane due to shear failure during the failure, and the limestone with larger compressive strength can withstand shear load by using the shear strength of the granular particles. When the cementing matrix in the cemented granular fails or the particles in the cemented granular are broken, the interface of the backfilling body and the cemented granular undergoes non-uniform compression deformation, resulting in the stress concentration on the backfilling body on the interface damaged by the cemented granular, resulting in the shear failure of the upper backfilling body locally, and the failure of backfilling body is the contribution of both axial stress and non-uniform deformation of the interface

CKD-TransBTS: Clinical Knowledge-Driven Hybrid Transformer with Modality-Correlated Cross-Attention for Brain Tumor Segmentation

Brain tumor segmentation (BTS) in magnetic resonance image (MRI) is crucial for brain tumor diagnosis, cancer management and research purposes. With the great success of the ten-year BraTS challenges as well as the advances of CNN and Transformer algorithms, a lot of outstanding BTS models have been proposed to tackle the difficulties of BTS in different technical aspects. However, existing studies hardly consider how to fuse the multi-modality images in a reasonable manner. In this paper, we leverage the clinical knowledge of how radiologists diagnose brain tumors from multiple MRI modalities and propose a clinical knowledge-driven brain tumor segmentation model, called CKD-TransBTS. Instead of directly concatenating all the modalities, we re-organize the input modalities by separating them into two groups according to the imaging principle of MRI. A dual-branch hybrid encoder with the proposed modality-correlated cross-attention block (MCCA) is designed to extract the multi-modality image features. The proposed model inherits the strengths from both Transformer and CNN with the local feature representation ability for precise lesion boundaries and long-range feature extraction for 3D volumetric images. To bridge the gap between Transformer and CNN features, we propose a Trans&CNN Feature Calibration block (TCFC) in the decoder. We compare the proposed model with five CNN-based models and six transformer-based models on the BraTS 2021 challenge dataset. Extensive experiments demonstrate that the proposed model achieves state-of-the-art brain tumor segmentation performance compared with all the competitors

HoVer-Trans: Anatomy-aware HoVer-Transformer for ROI-free Breast Cancer Diagnosis in Ultrasound Images

Ultrasonography is an important routine examination for breast cancer diagnosis, due to its non-invasive, radiation-free and low-cost properties. However, the diagnostic accuracy of breast cancer is still limited due to its inherent limitations. It would be a tremendous success if we can precisely diagnose breast cancer by breast ultrasound images (BUS). Many learning-based computer-aided diagnostic methods have been proposed to achieve breast cancer diagnosis/lesion classification. However, most of them require a pre-define ROI and then classify the lesion inside the ROI. Conventional classification backbones, such as VGG16 and ResNet50, can achieve promising classification results with no ROI requirement. But these models lack interpretability, thus restricting their use in clinical practice. In this study, we propose a novel ROI-free model for breast cancer diagnosis in ultrasound images with interpretable feature representations. We leverage the anatomical prior knowledge that malignant and benign tumors have different spatial relationships between different tissue layers, and propose a HoVer-Transformer to formulate this prior knowledge. The proposed HoVer-Trans block extracts the inter- and intra-layer spatial information horizontally and vertically. We conduct and release an open dataset GDPH&SYSUCC for breast cancer diagnosis in BUS. The proposed model is evaluated in three datasets by comparing with four CNN-based models and two vision transformer models via five-fold cross validation. It achieves state-of-the-art classification performance with the best model interpretability. In the meanwhile, our proposed model outperforms two senior sonographers on the breast cancer diagnosis when only one BUS image is given

RETRACTED: MiR-22 Inhibition Alleviates Cardiac Dysfunction in Doxorubicin-Induced Cardiomyopathy by Targeting the sirt1/PGC-1α Pathway

Doxorubicin (DOX) cardiotoxicity is a life-threatening side effect that leads to a poor prognosis in patients receiving chemotherapy. We investigated the role of miR-22 in doxorubicin-induced cardiomyopathy and the underlying mechanism in vivo and in vitro. Specifically, we designed loss-of-function and gain-of-function experiments to identify the role of miR-22 in doxorubicin-induced cardiomyopathy. Our data suggested that inhibiting miR-22 alleviated cardiac fibrosis and cardiac dysfunction induced by doxorubicin. In addition, inhibiting miR-22 mitigated mitochondrial dysfunction through the sirt1/PGC-1α pathway. Knocking out miR-22 enhanced mitochondrial biogenesis, as evidenced by increased PGC-1α, TFAM, and NRF-1 expression in vivo. Furthermore, knocking out miR-22 rescued mitophagy, which was confirmed by increased expression of PINK1 and parkin and by the colocalization of LC3 and mitochondria. These protective effects were abolished by overexpressing miR-22. In conclusion, miR-22 may represent a new target to alleviate cardiac dysfunction in doxorubicin-induced cardiomyopathy and improve prognosis in patients receiving chemotherapy

Impact of Underground Coal Seam Mining on Stability and Slippage of the Loess Slope

How to quantitatively characterise the impact of underground coal mining on the stability and slippage of loess slopes is a key problem in the evaluation of mining damage under loess slopes, but it is more difficult to study this problem under the impact of the particular mechanical properties and topographical features of loess slopes. In order to clarify the impact of underground coal seam mining on the stability and slippage of the loess slope, theoretical analysis, numerical simulation and physical similarity simulation experiments are used to address the problem based on the theory of slope stability and strata movement. The results show that the stability coefficient of a mining slope (Kms) is introduced to quantitatively characterise the stability of a mining loess slope, and to measure the degree of landslide risk. Due to the superposition of slope movement caused by mining subsidence and slope sliding tendency, the slope is more unstable when mining along the slope than when mining against the slope. The slope angle and slope height are the most important factors influencing the Kms. The ratio of rock stratum thickness to mining height and the ratio of rock stratum thickness to soil stratum thickness are positively correlated with Kms, and the correlation is relatively strong. The range of variation of the volume weight, internal friction angle and cohesion of the loess is small, and the influence on Kms is relatively weak. Probability integral theory is used to construct the relationship between stability and slippage of mining loess slopes. Taking the mining of a working face under the loess slope of Ningtiaota Coal Mine (China) as an example, the predicted results of the slope movement and deformation theory are in good agreement with the similar simulation test results, reaching 93.57~97.97%

A Comprehensive Evaluation and Analysis of Ground Surface Damage Due to Mining under Villages Based on GIS

This paper aims to evaluate the severities and causes of ground surface building and cropland damages after coal mining in a better way, and to clarify the correlation between the damage assessment indexes that influence mining. Against the backdrop of multi-seam mining in certain coal mines in China, the estimated results of each displacement and deformation were analyzed using GIS technology. The damage range determined for each deformation index is divided according to the displacement and deformation combined with the virtue of damage judgment threshold. The damage ranges on the ground surface based on the comprehensive value of each displacement and deformation index were obtained through superimposing those ranges delineated by each displacement and deformation index, and the law on influence from displacement indexes upon various levels of damage was analyzed in a quantitative manner accordingly. The results showed that coal mining destroyed 14 buildings and a cropland area of 11.96 hm2; among them, building damage was only associated with displacement indexes E (horizontal deformation) and T (inclined deformation). Seven buildings were solely destroyed by T alone; five buildings were solely damaged by E; two buildings were damaged jointly by E and T; and, moreover, with the aggravation in building damage level, the proportion of building damage due to E decreased while the proportion of building damage under the same level due to T increased. Regarding cropland destruction, the damage due to T accounted for 33.48% while the damage jointly caused by W (Subsidence), E and T accounted for 30.45%. Moreover, the proportion of damaged cropland area due to inclined deformation T was positively correlated with cropland damage level. These findings can provide a reference for rational judgment regarding civilian building and cropland destruction on the ground surface after coal mining

Solid-state cooling: Thermoelectrics

The growing demand of thermal management in various fields such as miniaturized 5G chips has motivated researchers to develop new and high-performance solid-state refrigeration technologies, typically including multicaloric and thermoelectric (TE) cooling. Among them, TE cooling has attracted huge attention owing to its advantages of rapid response, large cooling temperature difference, high stability, and tunable device size. Bi2Te3-based alloys have long been the only commercialized TE cooling materials, while novel systems SnSe and Mg3(Bi,Sb)2 have recently been discovered as potential candidates. However, challenges and problems still require to be summarized and further resolved for realizing better cooling performance. In this review, we systematically investigate TE cooling from its internal mechanism, crucial parameters, to device design and applications. Furthermore, we summarize the current optimization strategies for existing TE cooling materials, and finally provide some personal prospects especially the material-planification concept on future research on establishing better TE cooling

Study and Application of Similar Material Ratio in Collapsible Loess

The similar material of collapsible loess is the basis and premise of the experimental study on the surface movement and deformation law of coal seam mining in collapsible loess-covered areas. The orthogonal experiment is used to make up similar material with different proportions using river sand and barite powder as aggregate, clay and gypsum as cementing material, and diatomite as adjusting material. The reasonable proportion of similar material in collapsible loess is studied by using range analysis, similar simulation, and field measurement. The results show that the content of diatomite plays a leading role in the collapsibility coefficient of similar material, and the collapsibility coefficient is positively correlated with the content of diatomite; moisture content is the main control of the cohesion of the material, and cohesion is negatively correlated with the moisture content; the ratio of bone-to-glue has the most significant effect on the internal friction angle, and the internal friction angle is positively correlated with the ratio of bone-to-glue. The reasonable ratio of the similar material in collapsible loess is 8 : 2 of the ratio of bone-to-glue, the ratio of clay-to-gypsum is 9 : 1, the barite powder content is 6%, the diatomite content is 23%, and the moisture content is 13%, and the mechanical parameters of the collapsible loess are 5.3%–6.3% different from the target value of similar material through laboratory tests, which can meet the experimental requirements. It is verified by a similar simulation experiment that the maximum surface subsidence value and the surface fracture width in the simulation results are 6.9% and 7.8% different from the field measured results, indicating a high degree of agreement. The results of the study have important references and guiding significance for the preparation of similar material with similar models